Prognostic nomogram that predicts progression-free survival and overall survival of patients with ovarian clear cell carcinoma
ObjectivesWe aims to develop nomograms to predict progression-free survival (PFS) and overall survival (OS) in patients with ovarian clear cell carcinoma (OCCC) after primary treatment and compare the predictive accuracy with the currently used International Federation of Gynecology and Obstetrics (...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.956380/full |
| _version_ | 1828337899345543168 |
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| author | Jiayi Li Jiayi Li Jiayi Li Dongyan Cao Dongyan Cao |
| author_facet | Jiayi Li Jiayi Li Jiayi Li Dongyan Cao Dongyan Cao |
| author_sort | Jiayi Li |
| collection | DOAJ |
| description | ObjectivesWe aims to develop nomograms to predict progression-free survival (PFS) and overall survival (OS) in patients with ovarian clear cell carcinoma (OCCC) after primary treatment and compare the predictive accuracy with the currently used International Federation of Gynecology and Obstetrics (FIGO) system.MethodsWe collected data from 358 Chinese patients diagnosed with OCCC and who underwent standard treatment at our hospital. Patients diagnosed from 1982-9 to 2011-12 were classified as the training group and patients diagnosed from 2012-1 to 2016-11 were classified as the validation group. Nomograms were developed based on the training group and was validated in the validation group. The predictive performance was determined by concordance index and calibration curve.ResultsThe most predictive nomogram for PFS was constructed using variables: thrombosis, the FIGO staging, residual of the tumor and distant metastasis, with a concordance index of 0.738. While the nomogram for OS consisted of thrombosis, lymph node metastasis, residual of the tumor, malignant ascites/washing, and platinum resistance, with a concordance index of 0.835. The nomograms were internally validated by concordance indexes of 0.775 and 0.807 for predicting PFS and OS, respectively. In comparison, the concordance statistics for OS based on the FIGO staging was significantly lower (P<0.05).ConclusionWe have established two prognostic nomograms for recurrence and long-term survival in patients with OCCC after primary treatment in a large Chinese center and validated them in patients from the same center. This tool used variables specifically related to OCCC and was more accurate than the FIGO system. It is relatively easy to use in clinic for patient counseling, postoperative management, and follow-up for individual patients. |
| first_indexed | 2024-04-13T22:21:06Z |
| format | Article |
| id | doaj.art-62dd3c340eb740558639b672014b2592 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-13T22:21:06Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-62dd3c340eb740558639b672014b25922022-12-22T02:27:15ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-10-011210.3389/fonc.2022.956380956380Prognostic nomogram that predicts progression-free survival and overall survival of patients with ovarian clear cell carcinomaJiayi Li0Jiayi Li1Jiayi Li2Dongyan Cao3Dongyan Cao4Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, ChinaDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, ChinaNational Clinical Research Center for Obstetric & Gynecologic Diseases Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, ChinaDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, ChinaNational Clinical Research Center for Obstetric & Gynecologic Diseases Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, ChinaObjectivesWe aims to develop nomograms to predict progression-free survival (PFS) and overall survival (OS) in patients with ovarian clear cell carcinoma (OCCC) after primary treatment and compare the predictive accuracy with the currently used International Federation of Gynecology and Obstetrics (FIGO) system.MethodsWe collected data from 358 Chinese patients diagnosed with OCCC and who underwent standard treatment at our hospital. Patients diagnosed from 1982-9 to 2011-12 were classified as the training group and patients diagnosed from 2012-1 to 2016-11 were classified as the validation group. Nomograms were developed based on the training group and was validated in the validation group. The predictive performance was determined by concordance index and calibration curve.ResultsThe most predictive nomogram for PFS was constructed using variables: thrombosis, the FIGO staging, residual of the tumor and distant metastasis, with a concordance index of 0.738. While the nomogram for OS consisted of thrombosis, lymph node metastasis, residual of the tumor, malignant ascites/washing, and platinum resistance, with a concordance index of 0.835. The nomograms were internally validated by concordance indexes of 0.775 and 0.807 for predicting PFS and OS, respectively. In comparison, the concordance statistics for OS based on the FIGO staging was significantly lower (P<0.05).ConclusionWe have established two prognostic nomograms for recurrence and long-term survival in patients with OCCC after primary treatment in a large Chinese center and validated them in patients from the same center. This tool used variables specifically related to OCCC and was more accurate than the FIGO system. It is relatively easy to use in clinic for patient counseling, postoperative management, and follow-up for individual patients.https://www.frontiersin.org/articles/10.3389/fonc.2022.956380/fullnomogramovarian clear cell carcinomaprogression-free survivaloverall survivalpredictive model |
| spellingShingle | Jiayi Li Jiayi Li Jiayi Li Dongyan Cao Dongyan Cao Prognostic nomogram that predicts progression-free survival and overall survival of patients with ovarian clear cell carcinoma Frontiers in Oncology nomogram ovarian clear cell carcinoma progression-free survival overall survival predictive model |
| title | Prognostic nomogram that predicts progression-free survival and overall survival of patients with ovarian clear cell carcinoma |
| title_full | Prognostic nomogram that predicts progression-free survival and overall survival of patients with ovarian clear cell carcinoma |
| title_fullStr | Prognostic nomogram that predicts progression-free survival and overall survival of patients with ovarian clear cell carcinoma |
| title_full_unstemmed | Prognostic nomogram that predicts progression-free survival and overall survival of patients with ovarian clear cell carcinoma |
| title_short | Prognostic nomogram that predicts progression-free survival and overall survival of patients with ovarian clear cell carcinoma |
| title_sort | prognostic nomogram that predicts progression free survival and overall survival of patients with ovarian clear cell carcinoma |
| topic | nomogram ovarian clear cell carcinoma progression-free survival overall survival predictive model |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.956380/full |
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