Acid-Sensing Ion Channel 2: Function and Modulation
Acid-sensing ion channels (ASICs) have an important influence on human physiology and pathology. They are members of the degenerin/epithelial sodium channel family. Four genes encode at least six subunits, which combine to form a variety of homotrimers and heterotrimers. Of these, ASIC1a homotrimers...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-01-01
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| Series: | Membranes |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0375/12/2/113 |
| _version_ | 1827654080789479424 |
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| author | Andy Sivils Felix Yang John Q. Wang Xiang-Ping Chu |
| author_facet | Andy Sivils Felix Yang John Q. Wang Xiang-Ping Chu |
| author_sort | Andy Sivils |
| collection | DOAJ |
| description | Acid-sensing ion channels (ASICs) have an important influence on human physiology and pathology. They are members of the degenerin/epithelial sodium channel family. Four genes encode at least six subunits, which combine to form a variety of homotrimers and heterotrimers. Of these, ASIC1a homotrimers and ASIC1a/2 heterotrimers are most widely expressed in the central nervous system (CNS). Investigations into the function of ASIC1a in the CNS have revealed a wealth of information, culminating in multiple contemporary reviews. The lesser-studied ASIC2 subunits are in need of examination. This review will focus on ASIC2 in health and disease, with discussions of its role in modulating ASIC function, synaptic targeting, cardiovascular responses, and pharmacology, while exploring evidence of its influence in pathologies such as ischemic brain injury, multiple sclerosis, epilepsy, migraines, drug addiction, etc. This information substantiates the ASIC2 protein as a potential therapeutic target for various neurological, psychological, and cerebrovascular diseases. |
| first_indexed | 2024-03-09T21:28:30Z |
| format | Article |
| id | doaj.art-62dda99c3f3840fdacbb86c456af64b1 |
| institution | Directory Open Access Journal |
| issn | 2077-0375 |
| language | English |
| last_indexed | 2024-03-09T21:28:30Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Membranes |
| spelling | doaj.art-62dda99c3f3840fdacbb86c456af64b12023-11-23T21:02:01ZengMDPI AGMembranes2077-03752022-01-0112211310.3390/membranes12020113Acid-Sensing Ion Channel 2: Function and ModulationAndy Sivils0Felix Yang1John Q. Wang2Xiang-Ping Chu3Department of Biomedical Sciences, School of Medicine, University of Missouri, Kansas City, MO 64108, USADepartment of Biomedical Sciences, School of Medicine, University of Missouri, Kansas City, MO 64108, USADepartment of Biomedical Sciences, School of Medicine, University of Missouri, Kansas City, MO 64108, USADepartment of Biomedical Sciences, School of Medicine, University of Missouri, Kansas City, MO 64108, USAAcid-sensing ion channels (ASICs) have an important influence on human physiology and pathology. They are members of the degenerin/epithelial sodium channel family. Four genes encode at least six subunits, which combine to form a variety of homotrimers and heterotrimers. Of these, ASIC1a homotrimers and ASIC1a/2 heterotrimers are most widely expressed in the central nervous system (CNS). Investigations into the function of ASIC1a in the CNS have revealed a wealth of information, culminating in multiple contemporary reviews. The lesser-studied ASIC2 subunits are in need of examination. This review will focus on ASIC2 in health and disease, with discussions of its role in modulating ASIC function, synaptic targeting, cardiovascular responses, and pharmacology, while exploring evidence of its influence in pathologies such as ischemic brain injury, multiple sclerosis, epilepsy, migraines, drug addiction, etc. This information substantiates the ASIC2 protein as a potential therapeutic target for various neurological, psychological, and cerebrovascular diseases.https://www.mdpi.com/2077-0375/12/2/113acid-sensing ion channelsASIC2functionphysiologypathologypharmacology |
| spellingShingle | Andy Sivils Felix Yang John Q. Wang Xiang-Ping Chu Acid-Sensing Ion Channel 2: Function and Modulation Membranes acid-sensing ion channels ASIC2 function physiology pathology pharmacology |
| title | Acid-Sensing Ion Channel 2: Function and Modulation |
| title_full | Acid-Sensing Ion Channel 2: Function and Modulation |
| title_fullStr | Acid-Sensing Ion Channel 2: Function and Modulation |
| title_full_unstemmed | Acid-Sensing Ion Channel 2: Function and Modulation |
| title_short | Acid-Sensing Ion Channel 2: Function and Modulation |
| title_sort | acid sensing ion channel 2 function and modulation |
| topic | acid-sensing ion channels ASIC2 function physiology pathology pharmacology |
| url | https://www.mdpi.com/2077-0375/12/2/113 |
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