Family History of Autoimmune Thyroid Disease
The aim of this study was estimate the clinical characteristics of Graves' disease (GD) and Hashimoto's thyroiditis (HT) in first@degree relatives of persons in families with autoimmune thyroid diseases (AITD). Patients: Eighty one patients with AITD of 40 families, mean age (+/@s.d.) 41.9...
| Format: | Article |
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| Language: | Russian |
| Published: |
Endocrinology Research Centre
2013-12-01
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| Series: | Клиническая и экспериментальная тиреоидология |
| Subjects: | |
| Online Access: | https://cet-endojournals.ru/ket/article/viewFile/6569/4346 |
| _version_ | 1819138633995649024 |
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| collection | DOAJ |
| description | The aim of this study was estimate the clinical characteristics of Graves' disease (GD) and Hashimoto's thyroiditis (HT) in first@degree relatives of persons in families with autoimmune thyroid diseases (AITD). Patients: Eighty one patients with AITD of 40 families, mean age (+/@s.d.) 41.9 ± 1.8; range 18-73 years. In 10 families (25%) AITD traced among siblings, whose average age was 33.6 ± 3.5 years, 29 families (72.5%) - of two generations (parent@ descendant) 57.4 ± 1.6 and 32.2 ± 1.5 years, p = 0.001, respectively. In one family (2.5%) the disease was traced in both parents and their offspring. Results. Among patients with a positive family history for AITD is dominated by a pair of parent - descendant with a diagnosis of hypothyroidism (55%). Preliminary evidence of genetic anticipation in GD and HT. Patients with a family history of AITD ill of GD and HT to 50 years (84%), half - up to 30 years (47%). In familial forms of GD, a decrease in compensated patients for two generations. Among parents and descendant with hypothyroidism, there is a low percentage of persons over the medical euthyroidism (42%). |
| first_indexed | 2024-12-22T11:09:53Z |
| format | Article |
| id | doaj.art-62de45daa49647b9bd4cb30a3b7fe298 |
| institution | Directory Open Access Journal |
| issn | 1995-5472 2310-3787 |
| language | Russian |
| last_indexed | 2024-12-22T11:09:53Z |
| publishDate | 2013-12-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Клиническая и экспериментальная тиреоидология |
| spelling | doaj.art-62de45daa49647b9bd4cb30a3b7fe2982022-12-21T18:28:11ZrusEndocrinology Research CentreКлиническая и экспериментальная тиреоидология1995-54722310-37872013-12-0194394510.14341/ket20139439-456427Family History of Autoimmune Thyroid DiseaseThe aim of this study was estimate the clinical characteristics of Graves' disease (GD) and Hashimoto's thyroiditis (HT) in first@degree relatives of persons in families with autoimmune thyroid diseases (AITD). Patients: Eighty one patients with AITD of 40 families, mean age (+/@s.d.) 41.9 ± 1.8; range 18-73 years. In 10 families (25%) AITD traced among siblings, whose average age was 33.6 ± 3.5 years, 29 families (72.5%) - of two generations (parent@ descendant) 57.4 ± 1.6 and 32.2 ± 1.5 years, p = 0.001, respectively. In one family (2.5%) the disease was traced in both parents and their offspring. Results. Among patients with a positive family history for AITD is dominated by a pair of parent - descendant with a diagnosis of hypothyroidism (55%). Preliminary evidence of genetic anticipation in GD and HT. Patients with a family history of AITD ill of GD and HT to 50 years (84%), half - up to 30 years (47%). In familial forms of GD, a decrease in compensated patients for two generations. Among parents and descendant with hypothyroidism, there is a low percentage of persons over the medical euthyroidism (42%).https://cet-endojournals.ru/ket/article/viewFile/6569/4346family history of autoimmune thyroid diseasegraves' diseasehashimoto's thyroiditishypothyroidismparentsdescendants |
| spellingShingle | Family History of Autoimmune Thyroid Disease Клиническая и экспериментальная тиреоидология family history of autoimmune thyroid disease graves' disease hashimoto's thyroiditis hypothyroidism parents descendants |
| title | Family History of Autoimmune Thyroid Disease |
| title_full | Family History of Autoimmune Thyroid Disease |
| title_fullStr | Family History of Autoimmune Thyroid Disease |
| title_full_unstemmed | Family History of Autoimmune Thyroid Disease |
| title_short | Family History of Autoimmune Thyroid Disease |
| title_sort | family history of autoimmune thyroid disease |
| topic | family history of autoimmune thyroid disease graves' disease hashimoto's thyroiditis hypothyroidism parents descendants |
| url | https://cet-endojournals.ru/ket/article/viewFile/6569/4346 |