Polyketide stereocontrol: a study in chemical biology
The biosynthesis of reduced polyketides in bacteria by modular polyketide synthases (PKSs) proceeds with exquisite stereocontrol. As the stereochemistry is intimately linked to the strong bioactivity of these molecules, the origins of stereochemical control are of significant interest in attempts to...
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2017-02-01
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| Series: | Beilstein Journal of Organic Chemistry |
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| Online Access: | https://doi.org/10.3762/bjoc.13.39 |
| _version_ | 1818451712217710592 |
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| author | Kira J. Weissman |
| author_facet | Kira J. Weissman |
| author_sort | Kira J. Weissman |
| collection | DOAJ |
| description | The biosynthesis of reduced polyketides in bacteria by modular polyketide synthases (PKSs) proceeds with exquisite stereocontrol. As the stereochemistry is intimately linked to the strong bioactivity of these molecules, the origins of stereochemical control are of significant interest in attempts to create derivatives of these compounds by genetic engineering. In this review, we discuss the current state of knowledge regarding this key aspect of the biosynthetic pathways. Given that much of this information has been obtained using chemical biology tools, work in this area serves as a showcase for the power of this approach to provide answers to fundamental biological questions. |
| first_indexed | 2024-12-14T21:11:33Z |
| format | Article |
| id | doaj.art-62de7815a28e4e08970656d9b1f580ef |
| institution | Directory Open Access Journal |
| issn | 1860-5397 |
| language | English |
| last_indexed | 2024-12-14T21:11:33Z |
| publishDate | 2017-02-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj.art-62de7815a28e4e08970656d9b1f580ef2022-12-21T22:47:13ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972017-02-0113134837110.3762/bjoc.13.391860-5397-13-39Polyketide stereocontrol: a study in chemical biologyKira J. Weissman0UMR 7365, Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), CNRS-Université de Lorraine, Biopôle de l’Université de Lorraine, Campus Biologie Santé, Avenue de la Forêt de Haye, BP 50184, 54505 Vandœuvre-lès-Nancy Cedex, FranceThe biosynthesis of reduced polyketides in bacteria by modular polyketide synthases (PKSs) proceeds with exquisite stereocontrol. As the stereochemistry is intimately linked to the strong bioactivity of these molecules, the origins of stereochemical control are of significant interest in attempts to create derivatives of these compounds by genetic engineering. In this review, we discuss the current state of knowledge regarding this key aspect of the biosynthetic pathways. Given that much of this information has been obtained using chemical biology tools, work in this area serves as a showcase for the power of this approach to provide answers to fundamental biological questions.https://doi.org/10.3762/bjoc.13.39chemical biologypolyketide synthasesreduced polyketidesstereocontrol |
| spellingShingle | Kira J. Weissman Polyketide stereocontrol: a study in chemical biology Beilstein Journal of Organic Chemistry chemical biology polyketide synthases reduced polyketides stereocontrol |
| title | Polyketide stereocontrol: a study in chemical biology |
| title_full | Polyketide stereocontrol: a study in chemical biology |
| title_fullStr | Polyketide stereocontrol: a study in chemical biology |
| title_full_unstemmed | Polyketide stereocontrol: a study in chemical biology |
| title_short | Polyketide stereocontrol: a study in chemical biology |
| title_sort | polyketide stereocontrol a study in chemical biology |
| topic | chemical biology polyketide synthases reduced polyketides stereocontrol |
| url | https://doi.org/10.3762/bjoc.13.39 |
| work_keys_str_mv | AT kirajweissman polyketidestereocontrolastudyinchemicalbiology |