Asic3(-/-) female mice with hearing deficit affects social development of pups.
<h4>Background</h4>Infant crying is an important cue for mothers to respond adequately. Inappropriate response to infant crying can hinder social development in infants. In rodents, the pup-mother interaction largely depends on pup's calls. Mouse pups emit high frequency to ultrason...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2009-08-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19652708/?tool=EBI |
| _version_ | 1818952175277047808 |
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| author | Wei-Li Wu Chih-Hung Wang Eagle Yi-Kung Huang Chih-Cheng Chen |
| author_facet | Wei-Li Wu Chih-Hung Wang Eagle Yi-Kung Huang Chih-Cheng Chen |
| author_sort | Wei-Li Wu |
| collection | DOAJ |
| description | <h4>Background</h4>Infant crying is an important cue for mothers to respond adequately. Inappropriate response to infant crying can hinder social development in infants. In rodents, the pup-mother interaction largely depends on pup's calls. Mouse pups emit high frequency to ultrasonic vocalization (2-90 kHz) to communicate with their dam for maternal care. However, little is known about how the maternal response to infant crying or pup calls affects social development over the long term.<h4>Methodology/principal findings</h4>Here we used mice lacking acid-sensing ion channel 3 (Asic3(-/-)) to create a hearing deficit to probe the effect of caregiver hearing on maternal care and adolescent social development. Female Asic3(-/-) mice showed elevated hearing thresholds for low to ultrasonic frequency (4-32 kHz) on auditory brain stem response, which thus hindered their response to their pups' wriggling calls and ultrasonic vocalization, as well as their retrieval of pups. In adolescence, pups reared by Asic3(-/-) mice showed a social deficit in juvenile social behaviors as compared with those reared by wild-type or heterozygous dams. The social-deficit phenotype in juvenile mice reared by Asic3(-/-) mice was associated with the reduced serotonin transmission of the brain. However, Asic3(-/-) pups cross-fostered to wild-type dams showed rescued social deficit.<h4>Conclusions/significance</h4>Inadequate response to pups' calls as a result of ASIC3-dependent hearing loss confers maternal deficits in caregivers and social development deficits in their young. |
| first_indexed | 2024-12-20T09:46:12Z |
| format | Article |
| id | doaj.art-62e1fef146a7478fad3211b5060d94b2 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T09:46:12Z |
| publishDate | 2009-08-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-62e1fef146a7478fad3211b5060d94b22022-12-21T19:44:43ZengPublic Library of Science (PLoS)PLoS ONE1932-62032009-08-0148e650810.1371/journal.pone.0006508Asic3(-/-) female mice with hearing deficit affects social development of pups.Wei-Li WuChih-Hung WangEagle Yi-Kung HuangChih-Cheng Chen<h4>Background</h4>Infant crying is an important cue for mothers to respond adequately. Inappropriate response to infant crying can hinder social development in infants. In rodents, the pup-mother interaction largely depends on pup's calls. Mouse pups emit high frequency to ultrasonic vocalization (2-90 kHz) to communicate with their dam for maternal care. However, little is known about how the maternal response to infant crying or pup calls affects social development over the long term.<h4>Methodology/principal findings</h4>Here we used mice lacking acid-sensing ion channel 3 (Asic3(-/-)) to create a hearing deficit to probe the effect of caregiver hearing on maternal care and adolescent social development. Female Asic3(-/-) mice showed elevated hearing thresholds for low to ultrasonic frequency (4-32 kHz) on auditory brain stem response, which thus hindered their response to their pups' wriggling calls and ultrasonic vocalization, as well as their retrieval of pups. In adolescence, pups reared by Asic3(-/-) mice showed a social deficit in juvenile social behaviors as compared with those reared by wild-type or heterozygous dams. The social-deficit phenotype in juvenile mice reared by Asic3(-/-) mice was associated with the reduced serotonin transmission of the brain. However, Asic3(-/-) pups cross-fostered to wild-type dams showed rescued social deficit.<h4>Conclusions/significance</h4>Inadequate response to pups' calls as a result of ASIC3-dependent hearing loss confers maternal deficits in caregivers and social development deficits in their young.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19652708/?tool=EBI |
| spellingShingle | Wei-Li Wu Chih-Hung Wang Eagle Yi-Kung Huang Chih-Cheng Chen Asic3(-/-) female mice with hearing deficit affects social development of pups. PLoS ONE |
| title | Asic3(-/-) female mice with hearing deficit affects social development of pups. |
| title_full | Asic3(-/-) female mice with hearing deficit affects social development of pups. |
| title_fullStr | Asic3(-/-) female mice with hearing deficit affects social development of pups. |
| title_full_unstemmed | Asic3(-/-) female mice with hearing deficit affects social development of pups. |
| title_short | Asic3(-/-) female mice with hearing deficit affects social development of pups. |
| title_sort | asic3 female mice with hearing deficit affects social development of pups |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19652708/?tool=EBI |
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