Biochemical and in silico inhibition of bovine and human carbonic anhydrase-II by 1H-1,2,3-triazole analogs

Biochemical and in silico inhibition of bovine and human carbonic anhydrase-II by 1H-1,2,3-triazole analogs

A series of 1H-1,2,3-triazole analogs (7a–7d and 9a–9s) were synthesized via “click” chemistry and evaluated for in vitro carbonic anhydrase-II (bovine and human) inhibitory activity. The synthesis of intermediates, 7a and 7c, was achieved by using (S)-(-)ethyl lactate as a starting material. These...

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Bibliographic Details
Main Authors:	Majid Khan, Satya Kumar Avula, Sobia Ahsan Halim, Muhammad Waqas, Mufarreh Asmari, Ajmal Khan, Ahmed Al-Harrasi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-11-01
Series:	Frontiers in Chemistry
Subjects:	synthesis Suzuki–Miyaura cross-coupling “click” chemistry 1H-1,2,3-triazole analogs carbonic anhydrase-II inhibitory activity molecular docking studies
Online Access:	https://www.frontiersin.org/articles/10.3389/fchem.2022.1072337/full

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