Anti-arthritic effects of microneedling with bee venom gel
Objective: To combine with transdermal drug delivery using microneedle to simulate the bee venom therapy to evaluate the permeation of bee venom gel. Methods: In this study, the sodium urate and LPS were used on rats and mice to construct the model. Bee venom gel–microneedle combination effect on th...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2016-10-01
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| Series: | Journal of Traditional Chinese Medical Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095754816300898 |
| _version_ | 1797721702096961536 |
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| author | Mengdi Zhao Jie Bai Yang Lu Shouying Du Kexin Shang Pengyue Li Liu Yang Boyu Dong Ning Tan |
| author_facet | Mengdi Zhao Jie Bai Yang Lu Shouying Du Kexin Shang Pengyue Li Liu Yang Boyu Dong Ning Tan |
| author_sort | Mengdi Zhao |
| collection | DOAJ |
| description | Objective: To combine with transdermal drug delivery using microneedle to simulate the bee venom therapy to evaluate the permeation of bee venom gel.
Methods: In this study, the sodium urate and LPS were used on rats and mice to construct the model. Bee venom gel–microneedle combination effect on the model is to determine the role of microneedle gel permeation by observing inflammation factors.
Results: Compared with the model group, the bee venom gel–microneedle combination group can reduce the level of serum nitric oxide of the acute gouty inflammation model caused by sodium urate, and on LPS induced mouse model of acute inflammation effect and the micro.
Conclusions: Bee venom can significantly suppress the occurrence of gouty arthritis inflammation in rats and mice LPS inflammatory reaction. Choose the 750 μm microneedle with 10N force on skin about 3 minutes, bee venom can play the optimal role, and the anti-inflammatory effect is obvious. Microneedles can promote the percutaneous absorption of the active macromolecules bee venom gel. |
| first_indexed | 2024-03-12T09:37:05Z |
| format | Article |
| id | doaj.art-62e2b98119974f3cb14a85d5eba3018a |
| institution | Directory Open Access Journal |
| issn | 2095-7548 |
| language | English |
| last_indexed | 2024-03-12T09:37:05Z |
| publishDate | 2016-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Traditional Chinese Medical Sciences |
| spelling | doaj.art-62e2b98119974f3cb14a85d5eba3018a2023-09-02T13:31:05ZengElsevierJournal of Traditional Chinese Medical Sciences2095-75482016-10-013425626210.1016/j.jtcms.2016.09.005Anti-arthritic effects of microneedling with bee venom gelMengdi ZhaoJie BaiYang LuShouying DuKexin ShangPengyue LiLiu YangBoyu DongNing TanObjective: To combine with transdermal drug delivery using microneedle to simulate the bee venom therapy to evaluate the permeation of bee venom gel. Methods: In this study, the sodium urate and LPS were used on rats and mice to construct the model. Bee venom gel–microneedle combination effect on the model is to determine the role of microneedle gel permeation by observing inflammation factors. Results: Compared with the model group, the bee venom gel–microneedle combination group can reduce the level of serum nitric oxide of the acute gouty inflammation model caused by sodium urate, and on LPS induced mouse model of acute inflammation effect and the micro. Conclusions: Bee venom can significantly suppress the occurrence of gouty arthritis inflammation in rats and mice LPS inflammatory reaction. Choose the 750 μm microneedle with 10N force on skin about 3 minutes, bee venom can play the optimal role, and the anti-inflammatory effect is obvious. Microneedles can promote the percutaneous absorption of the active macromolecules bee venom gel.http://www.sciencedirect.com/science/article/pii/S2095754816300898ArthritisBee venomGelMelittinMicroneedle |
| spellingShingle | Mengdi Zhao Jie Bai Yang Lu Shouying Du Kexin Shang Pengyue Li Liu Yang Boyu Dong Ning Tan Anti-arthritic effects of microneedling with bee venom gel Journal of Traditional Chinese Medical Sciences Arthritis Bee venom Gel Melittin Microneedle |
| title | Anti-arthritic effects of microneedling with bee venom gel |
| title_full | Anti-arthritic effects of microneedling with bee venom gel |
| title_fullStr | Anti-arthritic effects of microneedling with bee venom gel |
| title_full_unstemmed | Anti-arthritic effects of microneedling with bee venom gel |
| title_short | Anti-arthritic effects of microneedling with bee venom gel |
| title_sort | anti arthritic effects of microneedling with bee venom gel |
| topic | Arthritis Bee venom Gel Melittin Microneedle |
| url | http://www.sciencedirect.com/science/article/pii/S2095754816300898 |
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