Effect of 6-week curcumin supplementation on aerobic capacity, antioxidant status and sirtuin 3 level in middle-aged amateur long-distance runners
Background The study was undertaken to evaluate the effect of 6-week supplementation with a daily dose of 2g of curcumin on VO2max and prooxidant/antioxidant homeostasis in middle-aged amateur long-distance runners during the preparatory period of the macrocycle.Methods Thirty runners were randomly...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Redox Report |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/13510002.2022.2123882 |
| _version_ | 1811266280973402112 |
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| author | Sebastian Bańkowski Miroslav Petr Michał Rozpara Ewa Sadowska-Krępa |
| author_facet | Sebastian Bańkowski Miroslav Petr Michał Rozpara Ewa Sadowska-Krępa |
| author_sort | Sebastian Bańkowski |
| collection | DOAJ |
| description | Background The study was undertaken to evaluate the effect of 6-week supplementation with a daily dose of 2g of curcumin on VO2max and prooxidant/antioxidant homeostasis in middle-aged amateur long-distance runners during the preparatory period of the macrocycle.Methods Thirty runners were randomly assigned to a placebo group (PL) and a curcumin-supplemented group (CU). Their VO2max was assessed before supplementation and after 6 weeks of supplementation. Venous blood samples were collected from the participants at rest, immediately after exercise, and after 1h of recovery to evaluate the activity of antioxidant enzymes (SOD, CAT, GPx), non-enzymatic antioxidants (GSH, UA) and sirtuin 3 level (SIRT 3), as well as the levels of oxidative stress markers (TOS/TOC, MDA, and 8-OHdG) and muscle damage markers (CK, LDH, and Mb).Results VO2max, the activity of enzymatic antioxidants, the concentrations of non-enzymatic antioxidants, the levels of oxidative stress markers, and the levels of muscle damage markers did not change significantly in the CU group over 6 weeks of supplementation with curcumin. However, the resting concentration of SIRT 3 was found to be significantly higher (p ≤ 0.05) compared with pre-supplementation.Conclusion Curcumin supplementation does not have a significant effect on VO2max and prooxidant/antioxidant homeostasis in runners. |
| first_indexed | 2024-04-12T20:40:29Z |
| format | Article |
| id | doaj.art-62e461909c2a478c9dacc77b107a5735 |
| institution | Directory Open Access Journal |
| issn | 1351-0002 1743-2928 |
| language | English |
| last_indexed | 2024-04-12T20:40:29Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Redox Report |
| spelling | doaj.art-62e461909c2a478c9dacc77b107a57352022-12-22T03:17:26ZengTaylor & Francis GroupRedox Report1351-00021743-29282022-12-0127118619210.1080/13510002.2022.2123882Effect of 6-week curcumin supplementation on aerobic capacity, antioxidant status and sirtuin 3 level in middle-aged amateur long-distance runnersSebastian Bańkowski0Miroslav Petr1Michał Rozpara2Ewa Sadowska-Krępa3Institute of Sport Sciences, the Jerzy Kukuczka Academy of Physical Education, Katowice, PolandDepartment of Physiology, Faculty of Physical Education and Sport, Charles University, Prague, Czech RepublicInstitute of Sport Sciences, the Jerzy Kukuczka Academy of Physical Education, Katowice, PolandInstitute of Sport Sciences, the Jerzy Kukuczka Academy of Physical Education, Katowice, PolandBackground The study was undertaken to evaluate the effect of 6-week supplementation with a daily dose of 2g of curcumin on VO2max and prooxidant/antioxidant homeostasis in middle-aged amateur long-distance runners during the preparatory period of the macrocycle.Methods Thirty runners were randomly assigned to a placebo group (PL) and a curcumin-supplemented group (CU). Their VO2max was assessed before supplementation and after 6 weeks of supplementation. Venous blood samples were collected from the participants at rest, immediately after exercise, and after 1h of recovery to evaluate the activity of antioxidant enzymes (SOD, CAT, GPx), non-enzymatic antioxidants (GSH, UA) and sirtuin 3 level (SIRT 3), as well as the levels of oxidative stress markers (TOS/TOC, MDA, and 8-OHdG) and muscle damage markers (CK, LDH, and Mb).Results VO2max, the activity of enzymatic antioxidants, the concentrations of non-enzymatic antioxidants, the levels of oxidative stress markers, and the levels of muscle damage markers did not change significantly in the CU group over 6 weeks of supplementation with curcumin. However, the resting concentration of SIRT 3 was found to be significantly higher (p ≤ 0.05) compared with pre-supplementation.Conclusion Curcumin supplementation does not have a significant effect on VO2max and prooxidant/antioxidant homeostasis in runners.https://www.tandfonline.com/doi/10.1080/13510002.2022.2123882flavonoidsSupplementationantioxidant enzymesnon-enzymatic antioxidantsoxidative stressprooxidant/antioxidant homeostasis |
| spellingShingle | Sebastian Bańkowski Miroslav Petr Michał Rozpara Ewa Sadowska-Krępa Effect of 6-week curcumin supplementation on aerobic capacity, antioxidant status and sirtuin 3 level in middle-aged amateur long-distance runners Redox Report flavonoids Supplementation antioxidant enzymes non-enzymatic antioxidants oxidative stress prooxidant/antioxidant homeostasis |
| title | Effect of 6-week curcumin supplementation on aerobic capacity, antioxidant status and sirtuin 3 level in middle-aged amateur long-distance runners |
| title_full | Effect of 6-week curcumin supplementation on aerobic capacity, antioxidant status and sirtuin 3 level in middle-aged amateur long-distance runners |
| title_fullStr | Effect of 6-week curcumin supplementation on aerobic capacity, antioxidant status and sirtuin 3 level in middle-aged amateur long-distance runners |
| title_full_unstemmed | Effect of 6-week curcumin supplementation on aerobic capacity, antioxidant status and sirtuin 3 level in middle-aged amateur long-distance runners |
| title_short | Effect of 6-week curcumin supplementation on aerobic capacity, antioxidant status and sirtuin 3 level in middle-aged amateur long-distance runners |
| title_sort | effect of 6 week curcumin supplementation on aerobic capacity antioxidant status and sirtuin 3 level in middle aged amateur long distance runners |
| topic | flavonoids Supplementation antioxidant enzymes non-enzymatic antioxidants oxidative stress prooxidant/antioxidant homeostasis |
| url | https://www.tandfonline.com/doi/10.1080/13510002.2022.2123882 |
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