The risk of asthma in patients with ankylosing spondylitis: a population-based cohort study.
The relationship between asthma and ankylosing spondylitis (AS) is controversial. We examined the risk of asthma among AS patients in a nationwide population.We conducted a retrospective cohort study using data from the National Health Insurance (NHI) system of Taiwan. The cohort included 5,974 pati...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4320111?pdf=render |
| _version_ | 1818339610311262208 |
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| author | Te-Chun Shen Cheng-Li Lin Chang-Ching Wei Chia-Hung Chen Chih-Yen Tu Te-Chun Hsia Chuen-Ming Shih Wu-Huei Hsu Fung-Chang Sung |
| author_facet | Te-Chun Shen Cheng-Li Lin Chang-Ching Wei Chia-Hung Chen Chih-Yen Tu Te-Chun Hsia Chuen-Ming Shih Wu-Huei Hsu Fung-Chang Sung |
| author_sort | Te-Chun Shen |
| collection | DOAJ |
| description | The relationship between asthma and ankylosing spondylitis (AS) is controversial. We examined the risk of asthma among AS patients in a nationwide population.We conducted a retrospective cohort study using data from the National Health Insurance (NHI) system of Taiwan. The cohort included 5,974 patients newly diagnosed with AS from 2000 to 2010. The date of diagnosis was defined as the index date. A 4-fold of general population without AS was randomly selected frequency matched by age, gender and the index year. The occurrence and hazard ratio (HR) of asthma were estimated by the end of 2011.The overall incidence of asthma was 1.74 folds greater in the AS cohort than in the non-AS cohort (8.26 versus 4.74 per 1000 person-years) with a multivariable Cox method measured adjusted HR of 1.54 (95% confidence interval (CI), 1.34-1.76). The adjusted HR of asthma associated with AS was higher in women (1.59; 95% CI, 1.33-1.90), those aged 50-64 years (1.66; 95% CI, 1.31-2.09), or those without comorbidities (1.82; 95% CI, 1.54-2.13).Patients with AS are at a higher risk of developing asthma than the general population, regardless of gender and age. The pathophysiology needs further investigation. |
| first_indexed | 2024-12-13T15:29:44Z |
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| id | doaj.art-62e72037c1c44d04b228f82fc77a37d9 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T15:29:44Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-62e72037c1c44d04b228f82fc77a37d92022-12-21T23:40:13ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01102e011660810.1371/journal.pone.0116608The risk of asthma in patients with ankylosing spondylitis: a population-based cohort study.Te-Chun ShenCheng-Li LinChang-Ching WeiChia-Hung ChenChih-Yen TuTe-Chun HsiaChuen-Ming ShihWu-Huei HsuFung-Chang SungThe relationship between asthma and ankylosing spondylitis (AS) is controversial. We examined the risk of asthma among AS patients in a nationwide population.We conducted a retrospective cohort study using data from the National Health Insurance (NHI) system of Taiwan. The cohort included 5,974 patients newly diagnosed with AS from 2000 to 2010. The date of diagnosis was defined as the index date. A 4-fold of general population without AS was randomly selected frequency matched by age, gender and the index year. The occurrence and hazard ratio (HR) of asthma were estimated by the end of 2011.The overall incidence of asthma was 1.74 folds greater in the AS cohort than in the non-AS cohort (8.26 versus 4.74 per 1000 person-years) with a multivariable Cox method measured adjusted HR of 1.54 (95% confidence interval (CI), 1.34-1.76). The adjusted HR of asthma associated with AS was higher in women (1.59; 95% CI, 1.33-1.90), those aged 50-64 years (1.66; 95% CI, 1.31-2.09), or those without comorbidities (1.82; 95% CI, 1.54-2.13).Patients with AS are at a higher risk of developing asthma than the general population, regardless of gender and age. The pathophysiology needs further investigation.http://europepmc.org/articles/PMC4320111?pdf=render |
| spellingShingle | Te-Chun Shen Cheng-Li Lin Chang-Ching Wei Chia-Hung Chen Chih-Yen Tu Te-Chun Hsia Chuen-Ming Shih Wu-Huei Hsu Fung-Chang Sung The risk of asthma in patients with ankylosing spondylitis: a population-based cohort study. PLoS ONE |
| title | The risk of asthma in patients with ankylosing spondylitis: a population-based cohort study. |
| title_full | The risk of asthma in patients with ankylosing spondylitis: a population-based cohort study. |
| title_fullStr | The risk of asthma in patients with ankylosing spondylitis: a population-based cohort study. |
| title_full_unstemmed | The risk of asthma in patients with ankylosing spondylitis: a population-based cohort study. |
| title_short | The risk of asthma in patients with ankylosing spondylitis: a population-based cohort study. |
| title_sort | risk of asthma in patients with ankylosing spondylitis a population based cohort study |
| url | http://europepmc.org/articles/PMC4320111?pdf=render |
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