Innovative Alveolar Socket Preservation Procedure Using Demineralized Tooth Dentin as Graft Biomaterial Covered with Three Reabsorbable Membranes: Human Histological Case Series Evaluation
Background: Extracted tooth material has been seen as a valuable alternative to synthetic biomaterials. Aims: A novel flapless alveolar socket preservation (ASP) procedure with demineralized extracted tooth dentin graft material covered by three reabsorbable membranes was histologically and clinical...
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| Format: | Article |
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MDPI AG
2023-01-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/13/3/1411 |
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| author | Elio Minetti Andrea Grassi Tomas Beca Campoy Andrea Palermo Filiberto Mastrangelo |
| author_facet | Elio Minetti Andrea Grassi Tomas Beca Campoy Andrea Palermo Filiberto Mastrangelo |
| author_sort | Elio Minetti |
| collection | DOAJ |
| description | Background: Extracted tooth material has been seen as a valuable alternative to synthetic biomaterials. Aims: A novel flapless alveolar socket preservation (ASP) procedure with demineralized extracted tooth dentin graft material covered by three reabsorbable membranes was histologically and clinically evaluated 4 months after bone healing. Methods: Ten patients were enrolled and separated into two groups. Five post-extractive sites without buccal and/or palatal bone walls were treated with the flapless ASP procedure with demineralized tooth dentin covered with three reabsorbable membranes (Group A—GA). Five patients were treated with primary wound closure covered only with a reabsorbable membrane (Group B—GB). Bone biopsies were performed for histologic and histomorphometric analyses. Results: In both procedures, all clinical outcomes showed good healing of hard and soft tissue and a good maintenance of maxillary architecture. The histological analysis showed no necrosis or inflammatory areas in either group. The histomorphometric analysis showed higher total bone volume in GA (62.78 ± 7.97%) compared to GB (48.04 ± 9.32%), higher vital new bone in GA (57.53 ± 11.16%) compared to GB (42.41 ± 13.06%) and similar values for residual graft in GA (5.24 ± 5.82%) compared to GB (5.29 ± 4.83%). Conclusions: The data obtained show how this novel technique, mixed with the dentin-derived graft material, seems to promote higher bone regeneration. |
| first_indexed | 2024-03-11T09:52:56Z |
| format | Article |
| id | doaj.art-62e7ca8c979c4c3888f7f7070de98ec6 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-11T09:52:56Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-62e7ca8c979c4c3888f7f7070de98ec62023-11-16T16:05:15ZengMDPI AGApplied Sciences2076-34172023-01-01133141110.3390/app13031411Innovative Alveolar Socket Preservation Procedure Using Demineralized Tooth Dentin as Graft Biomaterial Covered with Three Reabsorbable Membranes: Human Histological Case Series EvaluationElio Minetti0Andrea Grassi1Tomas Beca Campoy2Andrea Palermo3Filiberto Mastrangelo4Department of Biomedical, Surgical, Dental Science, University of Milan, 20161 Milan, ItalyIndependent Researcher, 41121 Reggio Emilia, ItalyIndependent Researcher, 28001 Madrid, SpainCollege of Medicine and Dentistry, Birmingham B4 6BN, UKClinical and Experimental Medicine Department, University of Foggia, 65121 Pescara, ItalyBackground: Extracted tooth material has been seen as a valuable alternative to synthetic biomaterials. Aims: A novel flapless alveolar socket preservation (ASP) procedure with demineralized extracted tooth dentin graft material covered by three reabsorbable membranes was histologically and clinically evaluated 4 months after bone healing. Methods: Ten patients were enrolled and separated into two groups. Five post-extractive sites without buccal and/or palatal bone walls were treated with the flapless ASP procedure with demineralized tooth dentin covered with three reabsorbable membranes (Group A—GA). Five patients were treated with primary wound closure covered only with a reabsorbable membrane (Group B—GB). Bone biopsies were performed for histologic and histomorphometric analyses. Results: In both procedures, all clinical outcomes showed good healing of hard and soft tissue and a good maintenance of maxillary architecture. The histological analysis showed no necrosis or inflammatory areas in either group. The histomorphometric analysis showed higher total bone volume in GA (62.78 ± 7.97%) compared to GB (48.04 ± 9.32%), higher vital new bone in GA (57.53 ± 11.16%) compared to GB (42.41 ± 13.06%) and similar values for residual graft in GA (5.24 ± 5.82%) compared to GB (5.29 ± 4.83%). Conclusions: The data obtained show how this novel technique, mixed with the dentin-derived graft material, seems to promote higher bone regeneration.https://www.mdpi.com/2076-3417/13/3/1411ASP alveolar socket preservationbone regenerationdemineralized tooth dentintooth transformerbone |
| spellingShingle | Elio Minetti Andrea Grassi Tomas Beca Campoy Andrea Palermo Filiberto Mastrangelo Innovative Alveolar Socket Preservation Procedure Using Demineralized Tooth Dentin as Graft Biomaterial Covered with Three Reabsorbable Membranes: Human Histological Case Series Evaluation Applied Sciences ASP alveolar socket preservation bone regeneration demineralized tooth dentin tooth transformer bone |
| title | Innovative Alveolar Socket Preservation Procedure Using Demineralized Tooth Dentin as Graft Biomaterial Covered with Three Reabsorbable Membranes: Human Histological Case Series Evaluation |
| title_full | Innovative Alveolar Socket Preservation Procedure Using Demineralized Tooth Dentin as Graft Biomaterial Covered with Three Reabsorbable Membranes: Human Histological Case Series Evaluation |
| title_fullStr | Innovative Alveolar Socket Preservation Procedure Using Demineralized Tooth Dentin as Graft Biomaterial Covered with Three Reabsorbable Membranes: Human Histological Case Series Evaluation |
| title_full_unstemmed | Innovative Alveolar Socket Preservation Procedure Using Demineralized Tooth Dentin as Graft Biomaterial Covered with Three Reabsorbable Membranes: Human Histological Case Series Evaluation |
| title_short | Innovative Alveolar Socket Preservation Procedure Using Demineralized Tooth Dentin as Graft Biomaterial Covered with Three Reabsorbable Membranes: Human Histological Case Series Evaluation |
| title_sort | innovative alveolar socket preservation procedure using demineralized tooth dentin as graft biomaterial covered with three reabsorbable membranes human histological case series evaluation |
| topic | ASP alveolar socket preservation bone regeneration demineralized tooth dentin tooth transformer bone |
| url | https://www.mdpi.com/2076-3417/13/3/1411 |
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