Effects of chlorhexidine preprocedural rinse on bacteremia in periodontal patients: a randomized clinical trial
Abstract Objective: Single dose of systemic antibiotics and short-term use of mouthwashes reduce bacteremia. However, the effects of a single dose of preprocedural rinse are still controversial. This study evaluated, in periodontally diseased patients, the effects of a pre-procedural mouth rinse on...
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| Format: | Article |
| Language: | English |
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University of São Paulo
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| Series: | Journal of Applied Oral Science |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572017000600586&lng=en&tlng=en |
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| author | Rodrigo Dalla Pria Balejo José Roberto Cortelli Fernando Oliveira Costa Renata Magalhães Cyrino Davi Romeiro Aquino Karina Cogo-Müller Taís Browne Miranda Sara Porto Moura Sheila Cavalca Cortelli |
| author_facet | Rodrigo Dalla Pria Balejo José Roberto Cortelli Fernando Oliveira Costa Renata Magalhães Cyrino Davi Romeiro Aquino Karina Cogo-Müller Taís Browne Miranda Sara Porto Moura Sheila Cavalca Cortelli |
| author_sort | Rodrigo Dalla Pria Balejo |
| collection | DOAJ |
| description | Abstract Objective: Single dose of systemic antibiotics and short-term use of mouthwashes reduce bacteremia. However, the effects of a single dose of preprocedural rinse are still controversial. This study evaluated, in periodontally diseased patients, the effects of a pre-procedural mouth rinse on induced bacteremia. Material and Methods: Systemically healthy individuals with gingivitis (n=27) or periodontitis (n = 27) were randomly allocated through a sealed envelope system to: 0.12% chlorhexidine pre-procedural rinse (13 gingivitis and 13 periodontitis patients) or no rinse before dental scaling (14 gingivitis and 15 periodontitis patients). Periodontal probing depth, clinical attachment level, plaque, and gingival indices were measured and subgingival samples were collected. Blood samples were collected before dental scaling, 2 and 6 minutes after scaling. Total bacterial load and levels of P. gingivalis were determined in oral and blood samples by real-time polymerase chain reaction, while aerobic and anaerobic counts were determined by culture in blood samples. The primary outcome was the antimicrobial effect of the pre-procedural rinse. Data was compared by Mann-Whitney and Signal tests (p<0.05). Results: In all sampling times, polymerase chain reaction revealed higher blood bacterial levels than culture (p<0.0001), while gingivitis patients presented lower bacterial levels in blood than periodontitis patients (p<0.0001). Individuals who experienced bacteremia showed worse mean clinical attachment level (3.4 mm vs. 1.1 mm) and more subgingival bacteria (p<0.005). The pre-procedural rinse did not reduce induced bacteremia. Conclusions: Bacteremia was influenced by periodontal parameters. In periodontally diseased patients, pre-procedural rinsing showed a discrete effect on bacteremia control. |
| first_indexed | 2024-12-13T17:02:16Z |
| format | Article |
| id | doaj.art-62e938c8dbff4eeb85476fc622d643de |
| institution | Directory Open Access Journal |
| issn | 1678-7765 |
| language | English |
| last_indexed | 2024-12-13T17:02:16Z |
| publisher | University of São Paulo |
| record_format | Article |
| series | Journal of Applied Oral Science |
| spelling | doaj.art-62e938c8dbff4eeb85476fc622d643de2022-12-21T23:37:47ZengUniversity of São PauloJournal of Applied Oral Science1678-776525658659510.1590/1678-7757-2017-0112S1678-77572017000600586Effects of chlorhexidine preprocedural rinse on bacteremia in periodontal patients: a randomized clinical trialRodrigo Dalla Pria BalejoJosé Roberto CortelliFernando Oliveira CostaRenata Magalhães CyrinoDavi Romeiro AquinoKarina Cogo-MüllerTaís Browne MirandaSara Porto MouraSheila Cavalca CortelliAbstract Objective: Single dose of systemic antibiotics and short-term use of mouthwashes reduce bacteremia. However, the effects of a single dose of preprocedural rinse are still controversial. This study evaluated, in periodontally diseased patients, the effects of a pre-procedural mouth rinse on induced bacteremia. Material and Methods: Systemically healthy individuals with gingivitis (n=27) or periodontitis (n = 27) were randomly allocated through a sealed envelope system to: 0.12% chlorhexidine pre-procedural rinse (13 gingivitis and 13 periodontitis patients) or no rinse before dental scaling (14 gingivitis and 15 periodontitis patients). Periodontal probing depth, clinical attachment level, plaque, and gingival indices were measured and subgingival samples were collected. Blood samples were collected before dental scaling, 2 and 6 minutes after scaling. Total bacterial load and levels of P. gingivalis were determined in oral and blood samples by real-time polymerase chain reaction, while aerobic and anaerobic counts were determined by culture in blood samples. The primary outcome was the antimicrobial effect of the pre-procedural rinse. Data was compared by Mann-Whitney and Signal tests (p<0.05). Results: In all sampling times, polymerase chain reaction revealed higher blood bacterial levels than culture (p<0.0001), while gingivitis patients presented lower bacterial levels in blood than periodontitis patients (p<0.0001). Individuals who experienced bacteremia showed worse mean clinical attachment level (3.4 mm vs. 1.1 mm) and more subgingival bacteria (p<0.005). The pre-procedural rinse did not reduce induced bacteremia. Conclusions: Bacteremia was influenced by periodontal parameters. In periodontally diseased patients, pre-procedural rinsing showed a discrete effect on bacteremia control.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572017000600586&lng=en&tlng=enBacteremiaPeriodontal diseasesPeriodontal debridementMouthwashes |
| spellingShingle | Rodrigo Dalla Pria Balejo José Roberto Cortelli Fernando Oliveira Costa Renata Magalhães Cyrino Davi Romeiro Aquino Karina Cogo-Müller Taís Browne Miranda Sara Porto Moura Sheila Cavalca Cortelli Effects of chlorhexidine preprocedural rinse on bacteremia in periodontal patients: a randomized clinical trial Journal of Applied Oral Science Bacteremia Periodontal diseases Periodontal debridement Mouthwashes |
| title | Effects of chlorhexidine preprocedural rinse on bacteremia in periodontal patients: a randomized clinical trial |
| title_full | Effects of chlorhexidine preprocedural rinse on bacteremia in periodontal patients: a randomized clinical trial |
| title_fullStr | Effects of chlorhexidine preprocedural rinse on bacteremia in periodontal patients: a randomized clinical trial |
| title_full_unstemmed | Effects of chlorhexidine preprocedural rinse on bacteremia in periodontal patients: a randomized clinical trial |
| title_short | Effects of chlorhexidine preprocedural rinse on bacteremia in periodontal patients: a randomized clinical trial |
| title_sort | effects of chlorhexidine preprocedural rinse on bacteremia in periodontal patients a randomized clinical trial |
| topic | Bacteremia Periodontal diseases Periodontal debridement Mouthwashes |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572017000600586&lng=en&tlng=en |
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