Evaluation of Liver Iron Content by Magnetic Resonance Imaging in Children with Acute Lymphoblastic Leukemia after Cessation of Treatment
Objective: There are a limited number of studies evaluating iron overload in childhood leukemia by magnetic resonance imaging (MRI). The aim of this study was to determine liver iron content (LIC) by MRI in children with acute lymphoblastic leukemia (ALL) who had completed treatment and to compare t...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2020-11-01
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| Series: | Turkish Journal of Hematology |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-99896 |
| _version_ | 1797916986195312640 |
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| author | Sezer Acar Salih Gözmen Selen Bayraktaroğlu Sultan Okur Acar Neryal Tahta Yeşim Aydınok Raziye C. Vergin |
| author_facet | Sezer Acar Salih Gözmen Selen Bayraktaroğlu Sultan Okur Acar Neryal Tahta Yeşim Aydınok Raziye C. Vergin |
| author_sort | Sezer Acar |
| collection | DOAJ |
| description | Objective: There are a limited number of studies evaluating iron overload in childhood leukemia by magnetic resonance imaging (MRI). The aim of this study was to determine liver iron content (LIC) by MRI in children with acute lymphoblastic leukemia (ALL) who had completed treatment and to compare those values with serum iron parameters. Materials and Methods: A total of 30 patients between the ages of 7 and 18 who had completed ALL treatment were included in the study. Serum iron parameters (serum iron, serum ferritin [SF], and total ironbinding capacity) and liver function tests were studied. R2 MRI was performed for determining LIC. Results: Normal LIC was detected in 22 (63.4%) of the cases. Seven (23.3%) had mild and 1 (3.3%) had moderate liver iron deposition. In contrast, severe iron overload was not detected in any of the cases. LIC levels were correlated with the numbers of packed red blood cell (pRBC) transfusions (r=0.637, p<0.001), pRBC transfusion volume (r=0.449, p<0.013), SF levels (r=0.561, p=0.001), and transferrin saturation (r=0.353, p=0.044). In addition, a positive correlation was found between the number of pRBC transfusions and SF levels (r=0.595, p<0.001). Conclusion: We showed that the frequency of liver iron deposition was low and clinically less significant after the end of treatment in childhood ALL patients. LIC was demonstrated to be related to SF and transfusion history. These findings support that SF and transfusion history may be used as references for monitoring iron accumulation or identifying cases for further examinations such as MRI. |
| first_indexed | 2024-04-10T13:06:07Z |
| format | Article |
| id | doaj.art-62ea650175ff4d9fb97376a09afc426a |
| institution | Directory Open Access Journal |
| issn | 1308-5263 |
| language | English |
| last_indexed | 2024-04-10T13:06:07Z |
| publishDate | 2020-11-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkish Journal of Hematology |
| spelling | doaj.art-62ea650175ff4d9fb97376a09afc426a2023-02-15T16:12:58ZengGalenos Publishing HouseTurkish Journal of Hematology1308-52632020-11-0137426327010.4274/tjh.galenos.2020.2019.0364TJH-99896Evaluation of Liver Iron Content by Magnetic Resonance Imaging in Children with Acute Lymphoblastic Leukemia after Cessation of TreatmentSezer Acar0Salih Gözmen1Selen Bayraktaroğlu2Sultan Okur Acar3Neryal Tahta4Yeşim Aydınok5Raziye C. Vergin6Dr. Behçet Uz Child Disease and Pediatric Surgery Training and Research Hospital, Department of Pediatrics, İzmir, TurkeyDr. Behcet Uz Child Disease and Pediatric Surgery Training and Research Hospital, Division of Pediatric Hematology and Oncology, İzmir, TurkeyEge University Faculty of Medicine, Department of Radiology, İzmir, TurkeyDr. Behcet Uz Child Disease and Pediatric Surgery Training and Research Hospital, Division of Pediatric Hematology and Oncology, İzmir, TurkeyDr. Behcet Uz Child Disease and Pediatric Surgery Training and Research Hospital, Division of Pediatric Hematology and Oncology, İzmir, TurkeyEge University Faculty of Medicine, Division of Pediatric Hematology and Oncology, İzmir, TurkeyDr. Behcet Uz Child Disease and Pediatric Surgery Training and Research Hospital, Division of Pediatric Hematology and Oncology, İzmir, TurkeyObjective: There are a limited number of studies evaluating iron overload in childhood leukemia by magnetic resonance imaging (MRI). The aim of this study was to determine liver iron content (LIC) by MRI in children with acute lymphoblastic leukemia (ALL) who had completed treatment and to compare those values with serum iron parameters. Materials and Methods: A total of 30 patients between the ages of 7 and 18 who had completed ALL treatment were included in the study. Serum iron parameters (serum iron, serum ferritin [SF], and total ironbinding capacity) and liver function tests were studied. R2 MRI was performed for determining LIC. Results: Normal LIC was detected in 22 (63.4%) of the cases. Seven (23.3%) had mild and 1 (3.3%) had moderate liver iron deposition. In contrast, severe iron overload was not detected in any of the cases. LIC levels were correlated with the numbers of packed red blood cell (pRBC) transfusions (r=0.637, p<0.001), pRBC transfusion volume (r=0.449, p<0.013), SF levels (r=0.561, p=0.001), and transferrin saturation (r=0.353, p=0.044). In addition, a positive correlation was found between the number of pRBC transfusions and SF levels (r=0.595, p<0.001). Conclusion: We showed that the frequency of liver iron deposition was low and clinically less significant after the end of treatment in childhood ALL patients. LIC was demonstrated to be related to SF and transfusion history. These findings support that SF and transfusion history may be used as references for monitoring iron accumulation or identifying cases for further examinations such as MRI.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-99896acute lymphoblastic leukemiairon overloadcomplicationspediatric leukemia |
| spellingShingle | Sezer Acar Salih Gözmen Selen Bayraktaroğlu Sultan Okur Acar Neryal Tahta Yeşim Aydınok Raziye C. Vergin Evaluation of Liver Iron Content by Magnetic Resonance Imaging in Children with Acute Lymphoblastic Leukemia after Cessation of Treatment Turkish Journal of Hematology acute lymphoblastic leukemia iron overload complications pediatric leukemia |
| title | Evaluation of Liver Iron Content by Magnetic Resonance Imaging in Children with Acute Lymphoblastic Leukemia after Cessation of Treatment |
| title_full | Evaluation of Liver Iron Content by Magnetic Resonance Imaging in Children with Acute Lymphoblastic Leukemia after Cessation of Treatment |
| title_fullStr | Evaluation of Liver Iron Content by Magnetic Resonance Imaging in Children with Acute Lymphoblastic Leukemia after Cessation of Treatment |
| title_full_unstemmed | Evaluation of Liver Iron Content by Magnetic Resonance Imaging in Children with Acute Lymphoblastic Leukemia after Cessation of Treatment |
| title_short | Evaluation of Liver Iron Content by Magnetic Resonance Imaging in Children with Acute Lymphoblastic Leukemia after Cessation of Treatment |
| title_sort | evaluation of liver iron content by magnetic resonance imaging in children with acute lymphoblastic leukemia after cessation of treatment |
| topic | acute lymphoblastic leukemia iron overload complications pediatric leukemia |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-99896 |
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