The Two Faces of Immune-Related lncRNAs in Head and Neck Squamous Cell Carcinoma
Head and neck squamous cell carcinoma (HNSCC) is a group of cancers originating from the mucosal epithelium in the oral cavity, larynx, oropharynx, nasopharynx, and hypopharynx. Molecular factors can be key in the diagnosis, prognosis, and treatment of HNSCC patients. Long non-coding RNAs (lncRNAs)...
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MDPI AG
2023-02-01
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| author | Lesly J. Bueno-Urquiza Marcela G. Martínez-Barajas Carlos E. Villegas-Mercado Jonathan R. García-Bernal Ana L. Pereira-Suárez Maribel Aguilar-Medina Mercedes Bermúdez |
| author_facet | Lesly J. Bueno-Urquiza Marcela G. Martínez-Barajas Carlos E. Villegas-Mercado Jonathan R. García-Bernal Ana L. Pereira-Suárez Maribel Aguilar-Medina Mercedes Bermúdez |
| author_sort | Lesly J. Bueno-Urquiza |
| collection | DOAJ |
| description | Head and neck squamous cell carcinoma (HNSCC) is a group of cancers originating from the mucosal epithelium in the oral cavity, larynx, oropharynx, nasopharynx, and hypopharynx. Molecular factors can be key in the diagnosis, prognosis, and treatment of HNSCC patients. Long non-coding RNAs (lncRNAs) are molecular regulators composed of 200 to 100,000 nucleotides that act on the modulation of genes that activate signaling pathways associated with oncogenic processes such as proliferation, migration, invasion, and metastasis in tumor cells. However, up until now, few studies have discussed the participation of lncRNAs in modeling the tumor microenvironment (TME) to generate a protumor or antitumor environment. Nevertheless, some immune-related lncRNAs have clinical relevance, since AL139158.2, AL031985.3, AC104794.2, AC099343.3, AL357519.1, SBDSP1, AS1AC108010.1, and TM4SF19-AS1 have been associated with overall survival (OS). MANCR is also related to poor OS and disease-specific survival. MiR31HG, TM4SF19-AS1, and LINC01123 are associated with poor prognosis. Meanwhile, LINC02195 and TRG-AS1 overexpression is associated with favorable prognosis. Moreover, ANRIL lncRNA induces resistance to cisplatin by inhibiting apoptosis. A superior understanding of the molecular mechanisms of lncRNAs that modify the characteristics of TME could contribute to increasing the efficacy of immunotherapy. |
| first_indexed | 2024-03-11T07:28:39Z |
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| language | English |
| last_indexed | 2024-03-11T07:28:39Z |
| publishDate | 2023-02-01 |
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| spelling | doaj.art-62ea72a7d68145d8a430315658ae80a12023-11-17T07:27:21ZengMDPI AGCells2073-44092023-02-0112572710.3390/cells12050727The Two Faces of Immune-Related lncRNAs in Head and Neck Squamous Cell CarcinomaLesly J. Bueno-Urquiza0Marcela G. Martínez-Barajas1Carlos E. Villegas-Mercado2Jonathan R. García-Bernal3Ana L. Pereira-Suárez4Maribel Aguilar-Medina5Mercedes Bermúdez6Department of Physiology, University Center for Health Sciences, University of Guadalajara, Guadalajara 44340, MexicoDepartment of Physiology, University Center for Health Sciences, University of Guadalajara, Guadalajara 44340, MexicoFaculty of Dentistry, Autonomous University of Chihuahua, Chihuahua 31000, MexicoDepartment of Physiology, University Center for Health Sciences, University of Guadalajara, Guadalajara 44340, MexicoDepartment of Microbiology and Pathology, University Center for Health Sciences, University of Guadalajara, Guadalajara 44340, MexicoFaculty of Biological and Chemical Sciences, Autonomous University of Sinaloa, Culiacán, Sinaloa 80030, MexicoFaculty of Dentistry, Autonomous University of Chihuahua, Chihuahua 31000, MexicoHead and neck squamous cell carcinoma (HNSCC) is a group of cancers originating from the mucosal epithelium in the oral cavity, larynx, oropharynx, nasopharynx, and hypopharynx. Molecular factors can be key in the diagnosis, prognosis, and treatment of HNSCC patients. Long non-coding RNAs (lncRNAs) are molecular regulators composed of 200 to 100,000 nucleotides that act on the modulation of genes that activate signaling pathways associated with oncogenic processes such as proliferation, migration, invasion, and metastasis in tumor cells. However, up until now, few studies have discussed the participation of lncRNAs in modeling the tumor microenvironment (TME) to generate a protumor or antitumor environment. Nevertheless, some immune-related lncRNAs have clinical relevance, since AL139158.2, AL031985.3, AC104794.2, AC099343.3, AL357519.1, SBDSP1, AS1AC108010.1, and TM4SF19-AS1 have been associated with overall survival (OS). MANCR is also related to poor OS and disease-specific survival. MiR31HG, TM4SF19-AS1, and LINC01123 are associated with poor prognosis. Meanwhile, LINC02195 and TRG-AS1 overexpression is associated with favorable prognosis. Moreover, ANRIL lncRNA induces resistance to cisplatin by inhibiting apoptosis. A superior understanding of the molecular mechanisms of lncRNAs that modify the characteristics of TME could contribute to increasing the efficacy of immunotherapy.https://www.mdpi.com/2073-4409/12/5/727HNSCCtumor microenvironmentLncRNAscancer-associated fibroblasts |
| spellingShingle | Lesly J. Bueno-Urquiza Marcela G. Martínez-Barajas Carlos E. Villegas-Mercado Jonathan R. García-Bernal Ana L. Pereira-Suárez Maribel Aguilar-Medina Mercedes Bermúdez The Two Faces of Immune-Related lncRNAs in Head and Neck Squamous Cell Carcinoma Cells HNSCC tumor microenvironment LncRNAs cancer-associated fibroblasts |
| title | The Two Faces of Immune-Related lncRNAs in Head and Neck Squamous Cell Carcinoma |
| title_full | The Two Faces of Immune-Related lncRNAs in Head and Neck Squamous Cell Carcinoma |
| title_fullStr | The Two Faces of Immune-Related lncRNAs in Head and Neck Squamous Cell Carcinoma |
| title_full_unstemmed | The Two Faces of Immune-Related lncRNAs in Head and Neck Squamous Cell Carcinoma |
| title_short | The Two Faces of Immune-Related lncRNAs in Head and Neck Squamous Cell Carcinoma |
| title_sort | two faces of immune related lncrnas in head and neck squamous cell carcinoma |
| topic | HNSCC tumor microenvironment LncRNAs cancer-associated fibroblasts |
| url | https://www.mdpi.com/2073-4409/12/5/727 |
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