The prognostic value of plasma soluble ST2 in hospitalized Chinese patients with heart failure.
sST2 has been shown to be a risk predictor in heart failure (HF). Our aim was to explore the characteristics and prognostic value of soluble ST2 (sST2) in hospitalized Chinese patients with HF.We consecutively enrolled 1528 hospitalized patients with HF. Receiver operating characteristic (ROC) and m...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4210209?pdf=render |
| _version_ | 1811281962001760256 |
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| author | Rongcheng Zhang Yuhui Zhang Jian Zhang Tao An Yan Huang Xiao Guo James L Januzzi Thomas P Cappola Shijie Yin Yunhong Wang Qiong Zhou Changhong Zou Shiming Ji Rong Lv |
| author_facet | Rongcheng Zhang Yuhui Zhang Jian Zhang Tao An Yan Huang Xiao Guo James L Januzzi Thomas P Cappola Shijie Yin Yunhong Wang Qiong Zhou Changhong Zou Shiming Ji Rong Lv |
| author_sort | Rongcheng Zhang |
| collection | DOAJ |
| description | sST2 has been shown to be a risk predictor in heart failure (HF). Our aim was to explore the characteristics and prognostic value of soluble ST2 (sST2) in hospitalized Chinese patients with HF.We consecutively enrolled 1528 hospitalized patients with HF. Receiver operating characteristic (ROC) and multivariable Cox proportional hazards analysis were used to assess the prognostic values of sST2. Adverse events were defined as all-cause death and cardiac transplantation. During a median follow-up of 19.1 months, 325 patients experienced adverse events. Compared with patients free of events, sST2 concentrations were significantly higher in patients with events (P<0.001). Univariable and multivariable Cox regression analyses showed sST2 concentrations were significantly associated with adverse events (per 1 log unit, adjusted hazard ratio 1.52, 95% confidence interval: 1.30 to 1.78, P<0.001). An sST2 concentration in the highest quartiles (>55.6 ng/mL) independently predicted events in comparison to the lowest quartile (≤25.2 ng/mL) when adjusted by multivariable model. In ROC analysis, the area under the curve for sST2 was not different from that for NT-proBNP in short and longer term. Over time, sST2 also improved discrimination and reclassification of risk beyond NT-proBNP.sST2 is a strong independent risk predictor in Chinese patients hospitalized with HF and can significantly provide additional prognostic value to NT-proBNP in risk prediction. |
| first_indexed | 2024-04-13T01:43:02Z |
| format | Article |
| id | doaj.art-62ee9a245a874628bd21f2705755d622 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T01:43:02Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-62ee9a245a874628bd21f2705755d6222022-12-22T03:08:07ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01910e11097610.1371/journal.pone.0110976The prognostic value of plasma soluble ST2 in hospitalized Chinese patients with heart failure.Rongcheng ZhangYuhui ZhangJian ZhangTao AnYan HuangXiao GuoJames L JanuzziThomas P CappolaShijie YinYunhong WangQiong ZhouChanghong ZouShiming JiRong LvsST2 has been shown to be a risk predictor in heart failure (HF). Our aim was to explore the characteristics and prognostic value of soluble ST2 (sST2) in hospitalized Chinese patients with HF.We consecutively enrolled 1528 hospitalized patients with HF. Receiver operating characteristic (ROC) and multivariable Cox proportional hazards analysis were used to assess the prognostic values of sST2. Adverse events were defined as all-cause death and cardiac transplantation. During a median follow-up of 19.1 months, 325 patients experienced adverse events. Compared with patients free of events, sST2 concentrations were significantly higher in patients with events (P<0.001). Univariable and multivariable Cox regression analyses showed sST2 concentrations were significantly associated with adverse events (per 1 log unit, adjusted hazard ratio 1.52, 95% confidence interval: 1.30 to 1.78, P<0.001). An sST2 concentration in the highest quartiles (>55.6 ng/mL) independently predicted events in comparison to the lowest quartile (≤25.2 ng/mL) when adjusted by multivariable model. In ROC analysis, the area under the curve for sST2 was not different from that for NT-proBNP in short and longer term. Over time, sST2 also improved discrimination and reclassification of risk beyond NT-proBNP.sST2 is a strong independent risk predictor in Chinese patients hospitalized with HF and can significantly provide additional prognostic value to NT-proBNP in risk prediction.http://europepmc.org/articles/PMC4210209?pdf=render |
| spellingShingle | Rongcheng Zhang Yuhui Zhang Jian Zhang Tao An Yan Huang Xiao Guo James L Januzzi Thomas P Cappola Shijie Yin Yunhong Wang Qiong Zhou Changhong Zou Shiming Ji Rong Lv The prognostic value of plasma soluble ST2 in hospitalized Chinese patients with heart failure. PLoS ONE |
| title | The prognostic value of plasma soluble ST2 in hospitalized Chinese patients with heart failure. |
| title_full | The prognostic value of plasma soluble ST2 in hospitalized Chinese patients with heart failure. |
| title_fullStr | The prognostic value of plasma soluble ST2 in hospitalized Chinese patients with heart failure. |
| title_full_unstemmed | The prognostic value of plasma soluble ST2 in hospitalized Chinese patients with heart failure. |
| title_short | The prognostic value of plasma soluble ST2 in hospitalized Chinese patients with heart failure. |
| title_sort | prognostic value of plasma soluble st2 in hospitalized chinese patients with heart failure |
| url | http://europepmc.org/articles/PMC4210209?pdf=render |
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