Current Advances in Pediatric Onset Multiple Sclerosis
Multiple sclerosis (MS) is an autoimmune inflammatory disease affecting the central nervous system leading to demyelination. MS in the pediatric population is rare, but has been shown to lead to significant disability over the duration of the disease. As we have learned more about pediatric MS, ther...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-03-01
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| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/8/4/71 |
| _version_ | 1797626470692028416 |
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| author | Kristen S. Fisher Fernando X. Cuascut Victor M. Rivera George J. Hutton |
| author_facet | Kristen S. Fisher Fernando X. Cuascut Victor M. Rivera George J. Hutton |
| author_sort | Kristen S. Fisher |
| collection | DOAJ |
| description | Multiple sclerosis (MS) is an autoimmune inflammatory disease affecting the central nervous system leading to demyelination. MS in the pediatric population is rare, but has been shown to lead to significant disability over the duration of the disease. As we have learned more about pediatric MS, there has been a development of improved diagnostic criteria leading to earlier diagnosis, earlier initiation of disease-modifying therapies (DMT), and an increasing number of DMT used in the treatment of pediatric MS. Over time, treatment with DMT has trended towards the initiation of higher efficacy treatment at time of diagnosis to help prevent further disease progression and accrual of disability over time, and there is evidence in current literature that supports this change in treatment patterns. In this review, we discuss the current knowledge in diagnosis, treatment, and clinical outcomes in pediatric MS. |
| first_indexed | 2024-03-11T10:10:51Z |
| format | Article |
| id | doaj.art-62eea336db694fc8a1d47c916dc9c757 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T10:10:51Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-62eea336db694fc8a1d47c916dc9c7572023-11-16T14:32:30ZengMDPI AGBiomedicines2227-90592020-03-01847110.3390/biomedicines8040071Current Advances in Pediatric Onset Multiple SclerosisKristen S. Fisher0Fernando X. Cuascut1Victor M. Rivera2George J. Hutton3Baylor College of Medicine, Texas Children’s Hospital, Houston, TX 77030, USABaylor College of Medicine, Maxine Mesinger Multiple Sclerosis Center, Houston, TX 77030, USABaylor College of Medicine, Maxine Mesinger Multiple Sclerosis Center, Houston, TX 77030, USABaylor College of Medicine, Maxine Mesinger Multiple Sclerosis Center, Houston, TX 77030, USAMultiple sclerosis (MS) is an autoimmune inflammatory disease affecting the central nervous system leading to demyelination. MS in the pediatric population is rare, but has been shown to lead to significant disability over the duration of the disease. As we have learned more about pediatric MS, there has been a development of improved diagnostic criteria leading to earlier diagnosis, earlier initiation of disease-modifying therapies (DMT), and an increasing number of DMT used in the treatment of pediatric MS. Over time, treatment with DMT has trended towards the initiation of higher efficacy treatment at time of diagnosis to help prevent further disease progression and accrual of disability over time, and there is evidence in current literature that supports this change in treatment patterns. In this review, we discuss the current knowledge in diagnosis, treatment, and clinical outcomes in pediatric MS.https://www.mdpi.com/2227-9059/8/4/71multiple sclerosispediatric multiple sclerosisneuroimmunologydemyelinating diseasepediatric neurologychild neurology |
| spellingShingle | Kristen S. Fisher Fernando X. Cuascut Victor M. Rivera George J. Hutton Current Advances in Pediatric Onset Multiple Sclerosis Biomedicines multiple sclerosis pediatric multiple sclerosis neuroimmunology demyelinating disease pediatric neurology child neurology |
| title | Current Advances in Pediatric Onset Multiple Sclerosis |
| title_full | Current Advances in Pediatric Onset Multiple Sclerosis |
| title_fullStr | Current Advances in Pediatric Onset Multiple Sclerosis |
| title_full_unstemmed | Current Advances in Pediatric Onset Multiple Sclerosis |
| title_short | Current Advances in Pediatric Onset Multiple Sclerosis |
| title_sort | current advances in pediatric onset multiple sclerosis |
| topic | multiple sclerosis pediatric multiple sclerosis neuroimmunology demyelinating disease pediatric neurology child neurology |
| url | https://www.mdpi.com/2227-9059/8/4/71 |
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