Copy Number Variations in Neuropsychiatric Disorders
Neuropsychiatric disorders are complex conditions that represent a significant global health burden with complex and multifactorial etiologies. Technological advances in recent years have improved our understanding of the genetic architecture of the major neuropsychiatric disorders and the genetic l...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/18/13671 |
| _version_ | 1797579812500406272 |
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| author | Gergely Büki Kinga Hadzsiev Judit Bene |
| author_facet | Gergely Büki Kinga Hadzsiev Judit Bene |
| author_sort | Gergely Büki |
| collection | DOAJ |
| description | Neuropsychiatric disorders are complex conditions that represent a significant global health burden with complex and multifactorial etiologies. Technological advances in recent years have improved our understanding of the genetic architecture of the major neuropsychiatric disorders and the genetic loci involved. Previous studies mainly investigated genome-wide significant SNPs to elucidate the cross-disorder and disorder-specific genetic basis of neuropsychiatric disorders. Although copy number variations represent a major source of genetic variations, they are known risk factors in developing a variety of human disorders, including certain neuropsychiatric diseases. In this review, we demonstrate the current understanding of CNVs contributing to liability for schizophrenia, bipolar disorder, and major depressive disorder. |
| first_indexed | 2024-03-10T22:41:12Z |
| format | Article |
| id | doaj.art-62eea74d78524b10975c6af366351f13 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T22:41:12Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-62eea74d78524b10975c6af366351f132023-11-19T11:01:23ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124181367110.3390/ijms241813671Copy Number Variations in Neuropsychiatric DisordersGergely Büki0Kinga Hadzsiev1Judit Bene2Department of Medical Genetics, Clinical Center, Medical School, University of Pécs, 7624 Pécs, HungaryDepartment of Medical Genetics, Clinical Center, Medical School, University of Pécs, 7624 Pécs, HungaryDepartment of Medical Genetics, Clinical Center, Medical School, University of Pécs, 7624 Pécs, HungaryNeuropsychiatric disorders are complex conditions that represent a significant global health burden with complex and multifactorial etiologies. Technological advances in recent years have improved our understanding of the genetic architecture of the major neuropsychiatric disorders and the genetic loci involved. Previous studies mainly investigated genome-wide significant SNPs to elucidate the cross-disorder and disorder-specific genetic basis of neuropsychiatric disorders. Although copy number variations represent a major source of genetic variations, they are known risk factors in developing a variety of human disorders, including certain neuropsychiatric diseases. In this review, we demonstrate the current understanding of CNVs contributing to liability for schizophrenia, bipolar disorder, and major depressive disorder.https://www.mdpi.com/1422-0067/24/18/13671psychiatric disorderschizophreniabipolar disordermajor depressive disorderCNVcopy number variation |
| spellingShingle | Gergely Büki Kinga Hadzsiev Judit Bene Copy Number Variations in Neuropsychiatric Disorders International Journal of Molecular Sciences psychiatric disorder schizophrenia bipolar disorder major depressive disorder CNV copy number variation |
| title | Copy Number Variations in Neuropsychiatric Disorders |
| title_full | Copy Number Variations in Neuropsychiatric Disorders |
| title_fullStr | Copy Number Variations in Neuropsychiatric Disorders |
| title_full_unstemmed | Copy Number Variations in Neuropsychiatric Disorders |
| title_short | Copy Number Variations in Neuropsychiatric Disorders |
| title_sort | copy number variations in neuropsychiatric disorders |
| topic | psychiatric disorder schizophrenia bipolar disorder major depressive disorder CNV copy number variation |
| url | https://www.mdpi.com/1422-0067/24/18/13671 |
| work_keys_str_mv | AT gergelybuki copynumbervariationsinneuropsychiatricdisorders AT kingahadzsiev copynumbervariationsinneuropsychiatricdisorders AT juditbene copynumbervariationsinneuropsychiatricdisorders |