A Rare Cause of Hypercalcemia: Immobilization A Case Report and Literature Review
Immobilization hypercalcemia (IH) mainly results from rapid bone turnover and may be seen after spinal cord injury or long bone fracture in particular in children and adolescents. The pathophysiology of this entity is entirely unknown. A-19 year-old, male quadriplegic adolescent was referred to our...
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| Format: | Article |
| Language: | English |
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Society of Turaz Bilim
2015-09-01
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| Series: | Medicine Science |
| Subjects: | |
| Online Access: | http://www.ejmanager.com/fulltextpdf.php?mno=171800 |
| _version_ | 1827361274530365440 |
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| author | Gulsah Elbuken Bahadir Yazicioglu Onur Ozturk Mehmet Derya Demirag |
| author_facet | Gulsah Elbuken Bahadir Yazicioglu Onur Ozturk Mehmet Derya Demirag |
| author_sort | Gulsah Elbuken |
| collection | DOAJ |
| description | Immobilization hypercalcemia (IH) mainly results from rapid bone turnover and may be seen after spinal cord injury or long bone fracture in particular in children and adolescents. The pathophysiology of this entity is entirely unknown. A-19 year-old, male quadriplegic adolescent was referred to our outpatient clinic by a family physician. At presentation he had some vague symptoms due to hypercalcemia including fatigue, nausea, vomiting, anorexia, constipation and dehydration. Laboratory investigations for hypercalcemia revealed low intact parathyroid hormone level, low 25-0H vitamin D, and high 24-hour urine calcium. He was diagnosed as having IH after all other causes of hypercalcemia were excluded. The pathophysiology of IH remains unclear. Treatment is directed towards lowering the serum calcium level. Up to date, intravenous hydration with isotonic saline, furosemide and salmon calcitonin have been the conventional therapies. Other treatment options include bisposphonates (such as etidronate, zoledronate or pamidronate) or, an inhibitor of receptor activator of nuclear factor kappa-B ligand (RANKL), denosumab. IH is a rare cause of hypercalcemia. Physicians should be aware of this condition when seeing patients with restricted physical activity. [Med-Science 2015; 4(3.000): 2521-7] |
| first_indexed | 2024-03-08T07:01:44Z |
| format | Article |
| id | doaj.art-62f052e72e434cb1a2327415d25f73bf |
| institution | Directory Open Access Journal |
| issn | 2147-0634 |
| language | English |
| last_indexed | 2024-03-08T07:01:44Z |
| publishDate | 2015-09-01 |
| publisher | Society of Turaz Bilim |
| record_format | Article |
| series | Medicine Science |
| spelling | doaj.art-62f052e72e434cb1a2327415d25f73bf2024-02-03T05:37:13ZengSociety of Turaz BilimMedicine Science2147-06342015-09-01432521710.5455/medscience.2015.04.8236171800A Rare Cause of Hypercalcemia: Immobilization A Case Report and Literature ReviewGulsah Elbuken0Bahadir Yazicioglu1Onur Ozturk2Mehmet Derya Demirag3Department of Endocrinology and Metabolism, Samsun Training and Research Hospital Department of Family Medicine, Samsun Training and Research Hospital Department of Family Medicine, Samsun Training and Research Hospital Chief of Internal Medicine Department, Samsun Training and Research HospitalImmobilization hypercalcemia (IH) mainly results from rapid bone turnover and may be seen after spinal cord injury or long bone fracture in particular in children and adolescents. The pathophysiology of this entity is entirely unknown. A-19 year-old, male quadriplegic adolescent was referred to our outpatient clinic by a family physician. At presentation he had some vague symptoms due to hypercalcemia including fatigue, nausea, vomiting, anorexia, constipation and dehydration. Laboratory investigations for hypercalcemia revealed low intact parathyroid hormone level, low 25-0H vitamin D, and high 24-hour urine calcium. He was diagnosed as having IH after all other causes of hypercalcemia were excluded. The pathophysiology of IH remains unclear. Treatment is directed towards lowering the serum calcium level. Up to date, intravenous hydration with isotonic saline, furosemide and salmon calcitonin have been the conventional therapies. Other treatment options include bisposphonates (such as etidronate, zoledronate or pamidronate) or, an inhibitor of receptor activator of nuclear factor kappa-B ligand (RANKL), denosumab. IH is a rare cause of hypercalcemia. Physicians should be aware of this condition when seeing patients with restricted physical activity. [Med-Science 2015; 4(3.000): 2521-7]http://www.ejmanager.com/fulltextpdf.php?mno=171800Hypercalcemiaimmobilizationquadriplegia |
| spellingShingle | Gulsah Elbuken Bahadir Yazicioglu Onur Ozturk Mehmet Derya Demirag A Rare Cause of Hypercalcemia: Immobilization A Case Report and Literature Review Medicine Science Hypercalcemia immobilization quadriplegia |
| title | A Rare Cause of Hypercalcemia: Immobilization A Case Report and Literature Review |
| title_full | A Rare Cause of Hypercalcemia: Immobilization A Case Report and Literature Review |
| title_fullStr | A Rare Cause of Hypercalcemia: Immobilization A Case Report and Literature Review |
| title_full_unstemmed | A Rare Cause of Hypercalcemia: Immobilization A Case Report and Literature Review |
| title_short | A Rare Cause of Hypercalcemia: Immobilization A Case Report and Literature Review |
| title_sort | rare cause of hypercalcemia immobilization a case report and literature review |
| topic | Hypercalcemia immobilization quadriplegia |
| url | http://www.ejmanager.com/fulltextpdf.php?mno=171800 |
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