<i>Shh</i>edding New Light on the Role of Hedgehog Signaling in Corneal Wound Healing
The cornea, an anterior ocular tissue that notably serves to protect the eye from external insults and refract light, requires constant epithelium renewal and efficient healing following injury to maintain ocular homeostasis. Although several key cell populations and molecular pathways implicated in...
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MDPI AG
2022-03-01
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Series: | International Journal of Molecular Sciences |
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Online Access: | https://www.mdpi.com/1422-0067/23/7/3630 |
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author | Xin Zhang Stéphane Mélik-Parsadaniantz Christophe Baudouin Annabelle Réaux-Le Goazigo Nathan Moreau |
author_facet | Xin Zhang Stéphane Mélik-Parsadaniantz Christophe Baudouin Annabelle Réaux-Le Goazigo Nathan Moreau |
author_sort | Xin Zhang |
collection | DOAJ |
description | The cornea, an anterior ocular tissue that notably serves to protect the eye from external insults and refract light, requires constant epithelium renewal and efficient healing following injury to maintain ocular homeostasis. Although several key cell populations and molecular pathways implicated in corneal wound healing have already been thoroughly investigated, insufficient/impaired or excessive corneal wound healing remains a major clinical issue in ophthalmology, and new avenues of research are still needed to further improve corneal wound healing. Because of its implication in numerous cellular/tissular homeostatic processes and oxidative stress, there is growing evidence of the role of Hedgehog signaling pathway in physiological and pathological corneal wound healing. Reviewing current scientific evidence, Hedgehog signaling and its effectors participate in corneal wound healing mainly at the level of the corneal and limbal epithelium, where Sonic Hedgehog-mediated signaling promotes limbal stem cell proliferation and corneal epithelial cell proliferation and migration following corneal injury. Hedgehog signaling could also participate in corneal epithelial barrier homeostasis and in pathological corneal healing such as corneal injury-related neovascularization. By gaining a better understanding of the role of this double-edged sword in physiological and pathological corneal wound healing, fascinating new research avenues and therapeutic strategies will undoubtedly emerge. |
first_indexed | 2024-03-09T11:47:30Z |
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institution | Directory Open Access Journal |
issn | 1661-6596 1422-0067 |
language | English |
last_indexed | 2024-03-09T11:47:30Z |
publishDate | 2022-03-01 |
publisher | MDPI AG |
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series | International Journal of Molecular Sciences |
spelling | doaj.art-62f333ff55644362865870443599179d2023-11-30T23:19:45ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-03-01237363010.3390/ijms23073630<i>Shh</i>edding New Light on the Role of Hedgehog Signaling in Corneal Wound HealingXin Zhang0Stéphane Mélik-Parsadaniantz1Christophe Baudouin2Annabelle Réaux-Le Goazigo3Nathan Moreau4CNRS, INSERM, Institut de la Vision, Sorbonne Université, 17 Rue Moreau, F-75012 Paris, FranceCNRS, INSERM, Institut de la Vision, Sorbonne Université, 17 Rue Moreau, F-75012 Paris, FranceCNRS, INSERM, Institut de la Vision, Sorbonne Université, 17 Rue Moreau, F-75012 Paris, FranceCNRS, INSERM, Institut de la Vision, Sorbonne Université, 17 Rue Moreau, F-75012 Paris, FranceCNRS, INSERM, Institut de la Vision, Sorbonne Université, 17 Rue Moreau, F-75012 Paris, FranceThe cornea, an anterior ocular tissue that notably serves to protect the eye from external insults and refract light, requires constant epithelium renewal and efficient healing following injury to maintain ocular homeostasis. Although several key cell populations and molecular pathways implicated in corneal wound healing have already been thoroughly investigated, insufficient/impaired or excessive corneal wound healing remains a major clinical issue in ophthalmology, and new avenues of research are still needed to further improve corneal wound healing. Because of its implication in numerous cellular/tissular homeostatic processes and oxidative stress, there is growing evidence of the role of Hedgehog signaling pathway in physiological and pathological corneal wound healing. Reviewing current scientific evidence, Hedgehog signaling and its effectors participate in corneal wound healing mainly at the level of the corneal and limbal epithelium, where Sonic Hedgehog-mediated signaling promotes limbal stem cell proliferation and corneal epithelial cell proliferation and migration following corneal injury. Hedgehog signaling could also participate in corneal epithelial barrier homeostasis and in pathological corneal healing such as corneal injury-related neovascularization. By gaining a better understanding of the role of this double-edged sword in physiological and pathological corneal wound healing, fascinating new research avenues and therapeutic strategies will undoubtedly emerge.https://www.mdpi.com/1422-0067/23/7/3630corneal wound healingcorneal homeostasiscorneal neovascularizationsonic hedgehognerve injuryoxidative stress |
spellingShingle | Xin Zhang Stéphane Mélik-Parsadaniantz Christophe Baudouin Annabelle Réaux-Le Goazigo Nathan Moreau <i>Shh</i>edding New Light on the Role of Hedgehog Signaling in Corneal Wound Healing International Journal of Molecular Sciences corneal wound healing corneal homeostasis corneal neovascularization sonic hedgehog nerve injury oxidative stress |
title | <i>Shh</i>edding New Light on the Role of Hedgehog Signaling in Corneal Wound Healing |
title_full | <i>Shh</i>edding New Light on the Role of Hedgehog Signaling in Corneal Wound Healing |
title_fullStr | <i>Shh</i>edding New Light on the Role of Hedgehog Signaling in Corneal Wound Healing |
title_full_unstemmed | <i>Shh</i>edding New Light on the Role of Hedgehog Signaling in Corneal Wound Healing |
title_short | <i>Shh</i>edding New Light on the Role of Hedgehog Signaling in Corneal Wound Healing |
title_sort | i shh i edding new light on the role of hedgehog signaling in corneal wound healing |
topic | corneal wound healing corneal homeostasis corneal neovascularization sonic hedgehog nerve injury oxidative stress |
url | https://www.mdpi.com/1422-0067/23/7/3630 |
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