IFNγ suppresses the expression of GFI1 and thereby inhibits Th2 cell proliferation.
While IFNγ is a well-known cytokine that actively promotes the type I immune response, it is also known to suppress the type II response by inhibiting the differentiation and proliferation of Th2 cells. However, the mechanism by which IFNγ suppresses Th2 cell proliferation is still not fully underst...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2021-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0260204 |
| _version_ | 1818965923407593472 |
|---|---|
| author | Murshed H Sarkar Ryoji Yagi Yukihiro Endo Ryo Koyama-Nasu Yangsong Wang Ichita Hasegawa Toshihiro Ito Ilkka S Junttila Jinfang Zhu Motoko Y Kimura Toshinori Nakayama |
| author_facet | Murshed H Sarkar Ryoji Yagi Yukihiro Endo Ryo Koyama-Nasu Yangsong Wang Ichita Hasegawa Toshihiro Ito Ilkka S Junttila Jinfang Zhu Motoko Y Kimura Toshinori Nakayama |
| author_sort | Murshed H Sarkar |
| collection | DOAJ |
| description | While IFNγ is a well-known cytokine that actively promotes the type I immune response, it is also known to suppress the type II response by inhibiting the differentiation and proliferation of Th2 cells. However, the mechanism by which IFNγ suppresses Th2 cell proliferation is still not fully understood. We found that IFNγ decreases the expression of growth factor independent-1 transcriptional repressor (GFI1) in Th2 cells, resulting in the inhibition of Th2 cell proliferation. The deletion of the Gfi1 gene in Th2 cells results in the failure of their proliferation, accompanied by an impaired cell cycle progression. In contrast, the enforced expression of GFI1 restores the defective Th2 cell proliferation, even in the presence of IFNγ. These results demonstrate that GFI1 is a key molecule in the IFNγ-mediated inhibition of Th2 cell proliferation. |
| first_indexed | 2024-12-20T13:24:43Z |
| format | Article |
| id | doaj.art-62f4a8a367f34005a027aa1979cbb21d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T13:24:43Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-62f4a8a367f34005a027aa1979cbb21d2022-12-21T19:39:17ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-011611e026020410.1371/journal.pone.0260204IFNγ suppresses the expression of GFI1 and thereby inhibits Th2 cell proliferation.Murshed H SarkarRyoji YagiYukihiro EndoRyo Koyama-NasuYangsong WangIchita HasegawaToshihiro ItoIlkka S JunttilaJinfang ZhuMotoko Y KimuraToshinori NakayamaWhile IFNγ is a well-known cytokine that actively promotes the type I immune response, it is also known to suppress the type II response by inhibiting the differentiation and proliferation of Th2 cells. However, the mechanism by which IFNγ suppresses Th2 cell proliferation is still not fully understood. We found that IFNγ decreases the expression of growth factor independent-1 transcriptional repressor (GFI1) in Th2 cells, resulting in the inhibition of Th2 cell proliferation. The deletion of the Gfi1 gene in Th2 cells results in the failure of their proliferation, accompanied by an impaired cell cycle progression. In contrast, the enforced expression of GFI1 restores the defective Th2 cell proliferation, even in the presence of IFNγ. These results demonstrate that GFI1 is a key molecule in the IFNγ-mediated inhibition of Th2 cell proliferation.https://doi.org/10.1371/journal.pone.0260204 |
| spellingShingle | Murshed H Sarkar Ryoji Yagi Yukihiro Endo Ryo Koyama-Nasu Yangsong Wang Ichita Hasegawa Toshihiro Ito Ilkka S Junttila Jinfang Zhu Motoko Y Kimura Toshinori Nakayama IFNγ suppresses the expression of GFI1 and thereby inhibits Th2 cell proliferation. PLoS ONE |
| title | IFNγ suppresses the expression of GFI1 and thereby inhibits Th2 cell proliferation. |
| title_full | IFNγ suppresses the expression of GFI1 and thereby inhibits Th2 cell proliferation. |
| title_fullStr | IFNγ suppresses the expression of GFI1 and thereby inhibits Th2 cell proliferation. |
| title_full_unstemmed | IFNγ suppresses the expression of GFI1 and thereby inhibits Th2 cell proliferation. |
| title_short | IFNγ suppresses the expression of GFI1 and thereby inhibits Th2 cell proliferation. |
| title_sort | ifnγ suppresses the expression of gfi1 and thereby inhibits th2 cell proliferation |
| url | https://doi.org/10.1371/journal.pone.0260204 |
| work_keys_str_mv | AT murshedhsarkar ifngsuppressestheexpressionofgfi1andtherebyinhibitsth2cellproliferation AT ryojiyagi ifngsuppressestheexpressionofgfi1andtherebyinhibitsth2cellproliferation AT yukihiroendo ifngsuppressestheexpressionofgfi1andtherebyinhibitsth2cellproliferation AT ryokoyamanasu ifngsuppressestheexpressionofgfi1andtherebyinhibitsth2cellproliferation AT yangsongwang ifngsuppressestheexpressionofgfi1andtherebyinhibitsth2cellproliferation AT ichitahasegawa ifngsuppressestheexpressionofgfi1andtherebyinhibitsth2cellproliferation AT toshihiroito ifngsuppressestheexpressionofgfi1andtherebyinhibitsth2cellproliferation AT ilkkasjunttila ifngsuppressestheexpressionofgfi1andtherebyinhibitsth2cellproliferation AT jinfangzhu ifngsuppressestheexpressionofgfi1andtherebyinhibitsth2cellproliferation AT motokoykimura ifngsuppressestheexpressionofgfi1andtherebyinhibitsth2cellproliferation AT toshinorinakayama ifngsuppressestheexpressionofgfi1andtherebyinhibitsth2cellproliferation |