IFNγ suppresses the expression of GFI1 and thereby inhibits Th2 cell proliferation.
While IFNγ is a well-known cytokine that actively promotes the type I immune response, it is also known to suppress the type II response by inhibiting the differentiation and proliferation of Th2 cells. However, the mechanism by which IFNγ suppresses Th2 cell proliferation is still not fully underst...
Main Authors: | Murshed H Sarkar, Ryoji Yagi, Yukihiro Endo, Ryo Koyama-Nasu, Yangsong Wang, Ichita Hasegawa, Toshihiro Ito, Ilkka S Junttila, Jinfang Zhu, Motoko Y Kimura, Toshinori Nakayama |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2021-01-01
|
Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0260204 |
Similar Items
-
Myosin Light Chain 9/12 Regulates the Pathogenesis of Inflammatory Bowel Disease
by: Masaya Yokoyama, et al.
Published: (2021-01-01) -
CD69 prevents PLZFhi innate precursors from prematurely exiting the thymus and aborting NKT2 cell differentiation
by: Motoko Y. Kimura, et al.
Published: (2018-09-01) -
Multifaceted Actions of GFI1 and GFI1B in Hematopoietic Stem Cell Self-Renewal and Lineage Commitment
by: Hugues Beauchemin, et al.
Published: (2020-10-01) -
GFI1B variants associated with thrombocytopenia
by: David J. Rabbolini, et al.
Published: (2017-07-01) -
Essential Role for CD30-Transglutaminase 2 Axis in Memory Th1 and Th17 Cell Generation
by: Akane S. Suzuki, et al.
Published: (2020-07-01)