Obesity is associated with subclinical hypothyroidism in the presence of thyroid autoantibodies: a cross-sectional study
Abstract Background Both obesity and subclinical hypothyroidism (SCH) have adverse effects on human body, but the relationship between these two conditions remains inconsistent. The presence of thyroid autoantibodies influences thyroid hormone levels, and may further mediate the interaction between...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-04-01
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| Series: | BMC Endocrine Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12902-022-00981-0 |
| _version_ | 1811290453185658880 |
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| author | Yuerong Yan Mingtong Xu Muchao Wu Xiaoyi Wang Feng Li Jin Zhang Lili You Xiaofang Pan Weilian Feng Jiayun Wu Caixia Chen Xiaohui Li Li Yan |
| author_facet | Yuerong Yan Mingtong Xu Muchao Wu Xiaoyi Wang Feng Li Jin Zhang Lili You Xiaofang Pan Weilian Feng Jiayun Wu Caixia Chen Xiaohui Li Li Yan |
| author_sort | Yuerong Yan |
| collection | DOAJ |
| description | Abstract Background Both obesity and subclinical hypothyroidism (SCH) have adverse effects on human body, but the relationship between these two conditions remains inconsistent. The presence of thyroid autoantibodies influences thyroid hormone levels, and may further mediate the interaction between obesity and SCH. This study aimed to explore the association among obesity, SCH and thyroid autoantibodies. Methods This study was a cross-sectional survey of 2505 subjects. Obesity was defined as a body mass index ≥28 kg/m2. Serum concentrations of thyroid hormones, thyroid peroxidase antibody (TPO-Ab) and thyroglobulin antibody (Tg-Ab) were examined. Logistic analysis was used to explore the relation among obesity, SCH and thyroid autoantibodies. Results A proportion of 11.54% (289/2505) subjects were obese, and 165 subjects had SCH. The positive rates of thyroid autoantibodies, TPO-Ab and Tg-Ab were 17.64% (442/2505), 11.02% (276/2505) and 14.13% (354/2505), respectively. The proportion of SCH was significantly higher in obese than nonobese subjects among those with positive thyroid autoantibodies [22.41% (13/58) vs. 11.72% (45/384), p = 0.025, χ2 test]. Moreover, obesity was significantly associated with SCH in the presence of thyroid autoantibodies after adjusting for confounding factors (OR 2.212, 95% CI 1.103 to 4.433, p = 0.025). A higher proportion of subjects with obesity had Tg-Ab positivity [17.99% (52/289) vs. 13.63% (302/2216), p = 0.045, χ2 test], and obesity remained significantly associated with Tg-Ab positivity by multiple logistic analysis (OR 1.504, 95% CI 1.077 to 2.101, p = 0.017). Conclusions Obesity was associated with SCH in the presence of thyroid autoantibodies. Examination of SCH is recommended in obese subjects with thyroid autoantibody positivity. |
| first_indexed | 2024-04-13T04:13:07Z |
| format | Article |
| id | doaj.art-62f58319ad8042209a351d7ab39c3b21 |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-04-13T04:13:07Z |
| publishDate | 2022-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-62f58319ad8042209a351d7ab39c3b212022-12-22T03:03:02ZengBMCBMC Endocrine Disorders1472-68232022-04-012211810.1186/s12902-022-00981-0Obesity is associated with subclinical hypothyroidism in the presence of thyroid autoantibodies: a cross-sectional studyYuerong Yan0Mingtong Xu1Muchao Wu2Xiaoyi Wang3Feng Li4Jin Zhang5Lili You6Xiaofang Pan7Weilian Feng8Jiayun Wu9Caixia Chen10Xiaohui Li11Li Yan12Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityAbstract Background Both obesity and subclinical hypothyroidism (SCH) have adverse effects on human body, but the relationship between these two conditions remains inconsistent. The presence of thyroid autoantibodies influences thyroid hormone levels, and may further mediate the interaction between obesity and SCH. This study aimed to explore the association among obesity, SCH and thyroid autoantibodies. Methods This study was a cross-sectional survey of 2505 subjects. Obesity was defined as a body mass index ≥28 kg/m2. Serum concentrations of thyroid hormones, thyroid peroxidase antibody (TPO-Ab) and thyroglobulin antibody (Tg-Ab) were examined. Logistic analysis was used to explore the relation among obesity, SCH and thyroid autoantibodies. Results A proportion of 11.54% (289/2505) subjects were obese, and 165 subjects had SCH. The positive rates of thyroid autoantibodies, TPO-Ab and Tg-Ab were 17.64% (442/2505), 11.02% (276/2505) and 14.13% (354/2505), respectively. The proportion of SCH was significantly higher in obese than nonobese subjects among those with positive thyroid autoantibodies [22.41% (13/58) vs. 11.72% (45/384), p = 0.025, χ2 test]. Moreover, obesity was significantly associated with SCH in the presence of thyroid autoantibodies after adjusting for confounding factors (OR 2.212, 95% CI 1.103 to 4.433, p = 0.025). A higher proportion of subjects with obesity had Tg-Ab positivity [17.99% (52/289) vs. 13.63% (302/2216), p = 0.045, χ2 test], and obesity remained significantly associated with Tg-Ab positivity by multiple logistic analysis (OR 1.504, 95% CI 1.077 to 2.101, p = 0.017). Conclusions Obesity was associated with SCH in the presence of thyroid autoantibodies. Examination of SCH is recommended in obese subjects with thyroid autoantibody positivity.https://doi.org/10.1186/s12902-022-00981-0ObesitySubclinical hypothyroidismThyroid autoantibodyBMITg-ab |
| spellingShingle | Yuerong Yan Mingtong Xu Muchao Wu Xiaoyi Wang Feng Li Jin Zhang Lili You Xiaofang Pan Weilian Feng Jiayun Wu Caixia Chen Xiaohui Li Li Yan Obesity is associated with subclinical hypothyroidism in the presence of thyroid autoantibodies: a cross-sectional study BMC Endocrine Disorders Obesity Subclinical hypothyroidism Thyroid autoantibody BMI Tg-ab |
| title | Obesity is associated with subclinical hypothyroidism in the presence of thyroid autoantibodies: a cross-sectional study |
| title_full | Obesity is associated with subclinical hypothyroidism in the presence of thyroid autoantibodies: a cross-sectional study |
| title_fullStr | Obesity is associated with subclinical hypothyroidism in the presence of thyroid autoantibodies: a cross-sectional study |
| title_full_unstemmed | Obesity is associated with subclinical hypothyroidism in the presence of thyroid autoantibodies: a cross-sectional study |
| title_short | Obesity is associated with subclinical hypothyroidism in the presence of thyroid autoantibodies: a cross-sectional study |
| title_sort | obesity is associated with subclinical hypothyroidism in the presence of thyroid autoantibodies a cross sectional study |
| topic | Obesity Subclinical hypothyroidism Thyroid autoantibody BMI Tg-ab |
| url | https://doi.org/10.1186/s12902-022-00981-0 |
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