Moving from Empirical to Rational Vaccine Design in the ‘Omics’ Era
An ideal vaccine provides long lasting protection against a pathogen by eliciting a well-rounded immune response which engages both innate and adaptive immunity. However, we have a limited understanding of how components of innate immunity, antibody and cell-mediated adaptive immunity interact and f...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-08-01
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| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/7/3/89 |
| _version_ | 1828282535480655872 |
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| author | Mansi Sharma Florian Krammer Adolfo García-Sastre Shashank Tripathi |
| author_facet | Mansi Sharma Florian Krammer Adolfo García-Sastre Shashank Tripathi |
| author_sort | Mansi Sharma |
| collection | DOAJ |
| description | An ideal vaccine provides long lasting protection against a pathogen by eliciting a well-rounded immune response which engages both innate and adaptive immunity. However, we have a limited understanding of how components of innate immunity, antibody and cell-mediated adaptive immunity interact and function together at a systems level. With advances in high-throughput ‘Omics’ methodologies it has become possible to capture global changes in the host, at a cellular and molecular level, that are induced by vaccination and infection. Analysis of these datasets has shown the promise of discovering mechanisms behind vaccine mediated protection, immunological memory, adverse effects as well as development of more efficient antigens and adjuvants. In this review, we will discuss how systems vaccinology takes advantage of new technology platforms and big data analysis, to enable the rational development of better vaccines. |
| first_indexed | 2024-04-13T08:31:08Z |
| format | Article |
| id | doaj.art-62f5ccdf4d4e4af0a13298ea3fc62618 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-04-13T08:31:08Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-62f5ccdf4d4e4af0a13298ea3fc626182022-12-22T02:54:15ZengMDPI AGVaccines2076-393X2019-08-01738910.3390/vaccines7030089vaccines7030089Moving from Empirical to Rational Vaccine Design in the ‘Omics’ EraMansi Sharma0Florian Krammer1Adolfo García-Sastre2Shashank Tripathi3Department of Microbiology & Cell Biology, Indian Institute of Science, Bengaluru 560012, IndiaDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USADepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USADepartment of Microbiology & Cell Biology, Indian Institute of Science, Bengaluru 560012, IndiaAn ideal vaccine provides long lasting protection against a pathogen by eliciting a well-rounded immune response which engages both innate and adaptive immunity. However, we have a limited understanding of how components of innate immunity, antibody and cell-mediated adaptive immunity interact and function together at a systems level. With advances in high-throughput ‘Omics’ methodologies it has become possible to capture global changes in the host, at a cellular and molecular level, that are induced by vaccination and infection. Analysis of these datasets has shown the promise of discovering mechanisms behind vaccine mediated protection, immunological memory, adverse effects as well as development of more efficient antigens and adjuvants. In this review, we will discuss how systems vaccinology takes advantage of new technology platforms and big data analysis, to enable the rational development of better vaccines.https://www.mdpi.com/2076-393X/7/3/89omicssystems biologysystems vaccinologyvaccinesignaturebiomarkersimmunogenicityprotectionadjuvantantigenmicrobiome |
| spellingShingle | Mansi Sharma Florian Krammer Adolfo García-Sastre Shashank Tripathi Moving from Empirical to Rational Vaccine Design in the ‘Omics’ Era Vaccines omics systems biology systems vaccinology vaccine signature biomarkers immunogenicity protection adjuvant antigen microbiome |
| title | Moving from Empirical to Rational Vaccine Design in the ‘Omics’ Era |
| title_full | Moving from Empirical to Rational Vaccine Design in the ‘Omics’ Era |
| title_fullStr | Moving from Empirical to Rational Vaccine Design in the ‘Omics’ Era |
| title_full_unstemmed | Moving from Empirical to Rational Vaccine Design in the ‘Omics’ Era |
| title_short | Moving from Empirical to Rational Vaccine Design in the ‘Omics’ Era |
| title_sort | moving from empirical to rational vaccine design in the omics era |
| topic | omics systems biology systems vaccinology vaccine signature biomarkers immunogenicity protection adjuvant antigen microbiome |
| url | https://www.mdpi.com/2076-393X/7/3/89 |
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