Entorhinal cortex volume in antipsychotic-naïve schizophrenia
Background: Entorhinal cortex (ERC), a multimodal sensory relay station for the hippocampus, is critically involved in learning, emotion, and novelty detection. One of the pathogenetic mechanistic bases in schizophrenia is proposed to involve aberrant information processing in the ERC. Several studi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2012-01-01
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| Series: | Indian Journal of Psychological Medicine |
| Subjects: | |
| Online Access: | http://www.ijpm.info/article.asp?issn=0253-7176;year=2012;volume=34;issue=2;spage=164;epage=169;aulast=Jose |
| _version_ | 1818597078297739264 |
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| author | Sam P Jose Eesha Sharma Janardhanan C Narayanaswamy Vishnurajan Rajendran Sunil V Kalmady Naren P Rao Ganesan Venkatasubramanian Bangalore N Gangadhar |
| author_facet | Sam P Jose Eesha Sharma Janardhanan C Narayanaswamy Vishnurajan Rajendran Sunil V Kalmady Naren P Rao Ganesan Venkatasubramanian Bangalore N Gangadhar |
| author_sort | Sam P Jose |
| collection | DOAJ |
| description | Background: Entorhinal cortex (ERC), a multimodal sensory relay station for the hippocampus, is critically involved in learning, emotion, and novelty detection. One of the pathogenetic mechanistic bases in schizophrenia is proposed to involve aberrant information processing in the ERC. Several studies have looked at cytoarchitectural and morphometric changes in the ERC, but results have been inconsistent possibly due to the potential confounding effects of antipsychotic treatment. Materials and Methods In this study, we have examined the entorhinal cortex volume in antipsychotic-naïve schizophrenia patients (n=40; M:F=22:18) in comparison with age, sex, and handedness, matched (as a group) with healthy subjects (n=42; M:F=25:17) using a valid method. 3-Tesla MR images with 1-mm sections were used and the data was analyzed using the SPSS software. Results: Female schizophrenia patients (1.25±0.22 mL) showed significant volume deficit in the right ERC in comparison with female healthy controls (1.45±0.34 mL) (F=4.9; P=0.03), after controlling for the potential confounding effects of intracranial volume. However, male patients did not differ from male controls. The left ERC volume did not differ between patients and controls. Conclusions: Consistent with the findings of a few earlier studies we found a reduction in the right ERC volume in patients. However, this was limited to women. Contextually, our study finding supports the role for ERC deficit in schizophrenia pathogenesis - perhaps mediated through aberrant novelty detection. Sex-differential observation of ERC volume deficit in schizophrenia needs further studies. |
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| format | Article |
| id | doaj.art-62f6ac6a7a484896b55be8116e1da5b0 |
| institution | Directory Open Access Journal |
| issn | 0253-7176 |
| language | English |
| last_indexed | 2024-12-16T11:42:05Z |
| publishDate | 2012-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Indian Journal of Psychological Medicine |
| spelling | doaj.art-62f6ac6a7a484896b55be8116e1da5b02022-12-21T22:32:55ZengSAGE PublishingIndian Journal of Psychological Medicine0253-71762012-01-0134216416910.4103/0253-7176.101787Entorhinal cortex volume in antipsychotic-naïve schizophreniaSam P JoseEesha SharmaJanardhanan C NarayanaswamyVishnurajan RajendranSunil V KalmadyNaren P RaoGanesan VenkatasubramanianBangalore N GangadharBackground: Entorhinal cortex (ERC), a multimodal sensory relay station for the hippocampus, is critically involved in learning, emotion, and novelty detection. One of the pathogenetic mechanistic bases in schizophrenia is proposed to involve aberrant information processing in the ERC. Several studies have looked at cytoarchitectural and morphometric changes in the ERC, but results have been inconsistent possibly due to the potential confounding effects of antipsychotic treatment. Materials and Methods In this study, we have examined the entorhinal cortex volume in antipsychotic-naïve schizophrenia patients (n=40; M:F=22:18) in comparison with age, sex, and handedness, matched (as a group) with healthy subjects (n=42; M:F=25:17) using a valid method. 3-Tesla MR images with 1-mm sections were used and the data was analyzed using the SPSS software. Results: Female schizophrenia patients (1.25±0.22 mL) showed significant volume deficit in the right ERC in comparison with female healthy controls (1.45±0.34 mL) (F=4.9; P=0.03), after controlling for the potential confounding effects of intracranial volume. However, male patients did not differ from male controls. The left ERC volume did not differ between patients and controls. Conclusions: Consistent with the findings of a few earlier studies we found a reduction in the right ERC volume in patients. However, this was limited to women. Contextually, our study finding supports the role for ERC deficit in schizophrenia pathogenesis - perhaps mediated through aberrant novelty detection. Sex-differential observation of ERC volume deficit in schizophrenia needs further studies.http://www.ijpm.info/article.asp?issn=0253-7176;year=2012;volume=34;issue=2;spage=164;epage=169;aulast=JoseEntorhinal cortexhippocampusschizophrenia |
| spellingShingle | Sam P Jose Eesha Sharma Janardhanan C Narayanaswamy Vishnurajan Rajendran Sunil V Kalmady Naren P Rao Ganesan Venkatasubramanian Bangalore N Gangadhar Entorhinal cortex volume in antipsychotic-naïve schizophrenia Indian Journal of Psychological Medicine Entorhinal cortex hippocampus schizophrenia |
| title | Entorhinal cortex volume in antipsychotic-naïve schizophrenia |
| title_full | Entorhinal cortex volume in antipsychotic-naïve schizophrenia |
| title_fullStr | Entorhinal cortex volume in antipsychotic-naïve schizophrenia |
| title_full_unstemmed | Entorhinal cortex volume in antipsychotic-naïve schizophrenia |
| title_short | Entorhinal cortex volume in antipsychotic-naïve schizophrenia |
| title_sort | entorhinal cortex volume in antipsychotic naive schizophrenia |
| topic | Entorhinal cortex hippocampus schizophrenia |
| url | http://www.ijpm.info/article.asp?issn=0253-7176;year=2012;volume=34;issue=2;spage=164;epage=169;aulast=Jose |
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