Dismantling airway disease with the use of new pulmonary function indices
We are currently limited in our abilities to diagnose, monitor disease status and manage chronic airway disease like asthma and chronic obstructive pulmonary disease (COPD). Conventional lung function measures often poorly reflect patient symptoms or are insensitive to changes, particularly in the s...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Respiratory Society
2019-03-01
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| Series: | European Respiratory Review |
| Online Access: | http://err.ersjournals.com/content/28/151/180122.full |
| _version_ | 1828387499661066240 |
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| author | Sabine C. Zimmermann Katrina O. Tonga Cindy Thamrin |
| author_facet | Sabine C. Zimmermann Katrina O. Tonga Cindy Thamrin |
| author_sort | Sabine C. Zimmermann |
| collection | DOAJ |
| description | We are currently limited in our abilities to diagnose, monitor disease status and manage chronic airway disease like asthma and chronic obstructive pulmonary disease (COPD). Conventional lung function measures often poorly reflect patient symptoms or are insensitive to changes, particularly in the small airways where disease may originate or manifest. Novel pulmonary function tests are becoming available which help us better characterise and understand chronic airway disease, and their translation and adoption from the research arena would potentially enable individualised patient care. In this article, we aim to describe two emerging lung function tests yielding novel pulmonary function indices, the forced oscillation technique (FOT) and multiple breath nitrogen washout (MBNW). With a particular focus on asthma and COPD, this article demonstrates how chronic airway disease mechanisms have been dismantled with the use of the FOT and MBNW. We describe their ability to assess detailed pulmonary mechanics for diagnostic and management purposes including response to bronchodilation and other treatments, relationship with symptoms, evaluation of acute exacerbations and recovery, and telemonitoring. The current limitations of both tests, as well as open questions/directions for further research, are also discussed. |
| first_indexed | 2024-12-10T05:54:22Z |
| format | Article |
| id | doaj.art-62f7d768815f4dd59915ac89066d007e |
| institution | Directory Open Access Journal |
| issn | 0905-9180 1600-0617 |
| language | English |
| last_indexed | 2024-12-10T05:54:22Z |
| publishDate | 2019-03-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | European Respiratory Review |
| spelling | doaj.art-62f7d768815f4dd59915ac89066d007e2022-12-22T01:59:57ZengEuropean Respiratory SocietyEuropean Respiratory Review0905-91801600-06172019-03-012815110.1183/16000617.0122-20180122-2018Dismantling airway disease with the use of new pulmonary function indicesSabine C. Zimmermann0Katrina O. Tonga1Cindy Thamrin2 Airway Physiology and Imaging Group, Woolcock Institute of Medical Research, The University of Sydney, Sydney, Australia Airway Physiology and Imaging Group, Woolcock Institute of Medical Research, The University of Sydney, Sydney, Australia Airway Physiology and Imaging Group, Woolcock Institute of Medical Research, The University of Sydney, Sydney, Australia We are currently limited in our abilities to diagnose, monitor disease status and manage chronic airway disease like asthma and chronic obstructive pulmonary disease (COPD). Conventional lung function measures often poorly reflect patient symptoms or are insensitive to changes, particularly in the small airways where disease may originate or manifest. Novel pulmonary function tests are becoming available which help us better characterise and understand chronic airway disease, and their translation and adoption from the research arena would potentially enable individualised patient care. In this article, we aim to describe two emerging lung function tests yielding novel pulmonary function indices, the forced oscillation technique (FOT) and multiple breath nitrogen washout (MBNW). With a particular focus on asthma and COPD, this article demonstrates how chronic airway disease mechanisms have been dismantled with the use of the FOT and MBNW. We describe their ability to assess detailed pulmonary mechanics for diagnostic and management purposes including response to bronchodilation and other treatments, relationship with symptoms, evaluation of acute exacerbations and recovery, and telemonitoring. The current limitations of both tests, as well as open questions/directions for further research, are also discussed.http://err.ersjournals.com/content/28/151/180122.full |
| spellingShingle | Sabine C. Zimmermann Katrina O. Tonga Cindy Thamrin Dismantling airway disease with the use of new pulmonary function indices European Respiratory Review |
| title | Dismantling airway disease with the use of new pulmonary function indices |
| title_full | Dismantling airway disease with the use of new pulmonary function indices |
| title_fullStr | Dismantling airway disease with the use of new pulmonary function indices |
| title_full_unstemmed | Dismantling airway disease with the use of new pulmonary function indices |
| title_short | Dismantling airway disease with the use of new pulmonary function indices |
| title_sort | dismantling airway disease with the use of new pulmonary function indices |
| url | http://err.ersjournals.com/content/28/151/180122.full |
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