Exploring the antioxidant effects of Aloe vera: Potential role in controlling liver function and lipid profile in high fat and fructose diet (HFFD) fed mice
Background: Fat-rich diets are believed to induce obesity and contribute to the development of diabetes and cardiovascular disease in contrast high fructose diet was reported to increase gut surface area and enhance nutrient uptake resulting in weight gain. The study investigated the role of Aloe ve...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-09-01
|
| Series: | Pharmacological Research - Modern Chinese Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667142522001105 |
| _version_ | 1798001808503734272 |
|---|---|
| author | Abdullahi Mukhtar Abubakar Nathan Isaac Dibal Martha Orendu Oche Attah Samaila Musa Chiroma |
| author_facet | Abdullahi Mukhtar Abubakar Nathan Isaac Dibal Martha Orendu Oche Attah Samaila Musa Chiroma |
| author_sort | Abdullahi Mukhtar Abubakar |
| collection | DOAJ |
| description | Background: Fat-rich diets are believed to induce obesity and contribute to the development of diabetes and cardiovascular disease in contrast high fructose diet was reported to increase gut surface area and enhance nutrient uptake resulting in weight gain. The study investigated the role of Aloe vera supplementation on oxidative stress, lipid profiles, and liver histology in high fat and fructose diet-fed mice. Methodology: Twenty mice were distributed into four groups (n = 5). The groups received a regular diet, high fat and fructose diet (HFFD), HFFD plus 10% Aloe vera (HFFD+AV1), and HFFD plus 20% Aloe vera (HFFD+AV2) respectively, for 10 weeks. Lipid profile and liver function were evaluated from the serum, antioxidant activities were evaluated from liver homogenate while the liver was processed for light microscopy. Results: The cholesterol level of HFFD+AV treated mice was significantly lower compared to HFFD treated mice. The alanine aminotransferase (ALT) level was significantly increased in HFFD-treated mice relative to the control. Aloe vera significantly improves albumin level plus superoxide dismutase and catalase activities of HFFD treated mice. The liver tissues of control and HFFD+AV2 treated mice showed normal hepatocytes. Conclusion: The study suggests that Aloe vera supplementation could prevent HFFD-induced oxidative stress and dyslipidemia. These findings might be used for further research on food supplementation to control metabolic disorders. |
| first_indexed | 2024-04-11T11:42:14Z |
| format | Article |
| id | doaj.art-62fe61cc473c416b828686a2d02c95cf |
| institution | Directory Open Access Journal |
| issn | 2667-1425 |
| language | English |
| last_indexed | 2024-04-11T11:42:14Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research - Modern Chinese Medicine |
| spelling | doaj.art-62fe61cc473c416b828686a2d02c95cf2022-12-22T04:25:47ZengElsevierPharmacological Research - Modern Chinese Medicine2667-14252022-09-014100150Exploring the antioxidant effects of Aloe vera: Potential role in controlling liver function and lipid profile in high fat and fructose diet (HFFD) fed miceAbdullahi Mukhtar Abubakar0Nathan Isaac Dibal1Martha Orendu Oche Attah2Samaila Musa Chiroma3Department of Human Anatomy, Faculty of Basic Medical Sciences, University of Maiduguri, Maiduguri PMB 1069, NigeriaDepartment of Human Anatomy, Faculty of Basic Medical Sciences, University of Maiduguri, Maiduguri PMB 1069, Nigeria; Corresponding author.Department of Human Anatomy, Faculty of Basic Medical Sciences, University of Maiduguri, Maiduguri PMB 1069, Nigeria; Faculty of Medicine, Cyprus International University, Nicosia, CyprusDepartment of Human Anatomy, Faculty of Basic Medical Sciences, University of Maiduguri, Maiduguri PMB 1069, NigeriaBackground: Fat-rich diets are believed to induce obesity and contribute to the development of diabetes and cardiovascular disease in contrast high fructose diet was reported to increase gut surface area and enhance nutrient uptake resulting in weight gain. The study investigated the role of Aloe vera supplementation on oxidative stress, lipid profiles, and liver histology in high fat and fructose diet-fed mice. Methodology: Twenty mice were distributed into four groups (n = 5). The groups received a regular diet, high fat and fructose diet (HFFD), HFFD plus 10% Aloe vera (HFFD+AV1), and HFFD plus 20% Aloe vera (HFFD+AV2) respectively, for 10 weeks. Lipid profile and liver function were evaluated from the serum, antioxidant activities were evaluated from liver homogenate while the liver was processed for light microscopy. Results: The cholesterol level of HFFD+AV treated mice was significantly lower compared to HFFD treated mice. The alanine aminotransferase (ALT) level was significantly increased in HFFD-treated mice relative to the control. Aloe vera significantly improves albumin level plus superoxide dismutase and catalase activities of HFFD treated mice. The liver tissues of control and HFFD+AV2 treated mice showed normal hepatocytes. Conclusion: The study suggests that Aloe vera supplementation could prevent HFFD-induced oxidative stress and dyslipidemia. These findings might be used for further research on food supplementation to control metabolic disorders.http://www.sciencedirect.com/science/article/pii/S2667142522001105AlbuminAloe veraCholesterolFatty liverHepatocytes |
| spellingShingle | Abdullahi Mukhtar Abubakar Nathan Isaac Dibal Martha Orendu Oche Attah Samaila Musa Chiroma Exploring the antioxidant effects of Aloe vera: Potential role in controlling liver function and lipid profile in high fat and fructose diet (HFFD) fed mice Pharmacological Research - Modern Chinese Medicine Albumin Aloe vera Cholesterol Fatty liver Hepatocytes |
| title | Exploring the antioxidant effects of Aloe vera: Potential role in controlling liver function and lipid profile in high fat and fructose diet (HFFD) fed mice |
| title_full | Exploring the antioxidant effects of Aloe vera: Potential role in controlling liver function and lipid profile in high fat and fructose diet (HFFD) fed mice |
| title_fullStr | Exploring the antioxidant effects of Aloe vera: Potential role in controlling liver function and lipid profile in high fat and fructose diet (HFFD) fed mice |
| title_full_unstemmed | Exploring the antioxidant effects of Aloe vera: Potential role in controlling liver function and lipid profile in high fat and fructose diet (HFFD) fed mice |
| title_short | Exploring the antioxidant effects of Aloe vera: Potential role in controlling liver function and lipid profile in high fat and fructose diet (HFFD) fed mice |
| title_sort | exploring the antioxidant effects of aloe vera potential role in controlling liver function and lipid profile in high fat and fructose diet hffd fed mice |
| topic | Albumin Aloe vera Cholesterol Fatty liver Hepatocytes |
| url | http://www.sciencedirect.com/science/article/pii/S2667142522001105 |
| work_keys_str_mv | AT abdullahimukhtarabubakar exploringtheantioxidanteffectsofaloeverapotentialroleincontrollingliverfunctionandlipidprofileinhighfatandfructosediethffdfedmice AT nathanisaacdibal exploringtheantioxidanteffectsofaloeverapotentialroleincontrollingliverfunctionandlipidprofileinhighfatandfructosediethffdfedmice AT marthaorenduocheattah exploringtheantioxidanteffectsofaloeverapotentialroleincontrollingliverfunctionandlipidprofileinhighfatandfructosediethffdfedmice AT samailamusachiroma exploringtheantioxidanteffectsofaloeverapotentialroleincontrollingliverfunctionandlipidprofileinhighfatandfructosediethffdfedmice |