Day-to-day variation of the kidney proximal tubular injury markers urinary cystatin C, KIM1, and NGAL in patients with chronic kidney disease
Background It is important to know the intraindividual variation of biomarkers to be able to distinguish a change of a biomarker due to the course of the disease from the normal biological variation of the marker. The purpose of this study was to investigate the day-to-day variability of urine marke...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | Renal Failure |
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| Online Access: | http://dx.doi.org/10.1080/0886022X.2020.1757463 |
| _version_ | 1818622080225116160 |
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| author | Inga Soveri Johanna Helmersson-Karlqvist Bengt Fellström Anders Larsson |
| author_facet | Inga Soveri Johanna Helmersson-Karlqvist Bengt Fellström Anders Larsson |
| author_sort | Inga Soveri |
| collection | DOAJ |
| description | Background It is important to know the intraindividual variation of biomarkers to be able to distinguish a change of a biomarker due to the course of the disease from the normal biological variation of the marker. The purpose of this study was to investigate the day-to-day variability of urine markers in nephrology patients. Materials 23 nephrology patients were included in the study. First morning urine samples were collected daily for ten consecutive days and analyzed for U-cystatin C, U-KIM1, U-NGAL and U-creatinine. The day-to-day variation was calculated as concentrations of the markers and as creatinine ratios. Values deviating more than the 90th percentile of the normal intraindividual variation was used to define a disease/treatment specific change. Results The day-to-day coefficient of variation (CV) for individual patients varied between 9.6 and 100.3% for NGAL (mean 45.6%) and between 8.8 and 107.3% for the NGAL/creatinine ratio (mean 43.8%). The corresponding values for KIM1 were between 10.9 and 60.2% (mean 30.1%) and for the ratio between 8.7 and 59.8% (mean 23.4%) and for cystatin C 3.8–67.4% (mean 25.0%) and for the cystatin C/creatinine ratio 5.9–78.4% (mean 24.8%). Conclusions The similar intraindividual CV values between the renal tubules damage markers and their corresponding creatinine ratios speaks against using creatinine ratio. Using the 90th percentiles of the CV values as a limit for clinical change means that NGAL has to change by 83.3%, KIM1 by 45.5% and Cystatin C by 46.3% before the change can be considered clinically significant in patients with chronic kidney disease. |
| first_indexed | 2024-12-16T18:19:29Z |
| format | Article |
| id | doaj.art-62fe62e77d6f45b7894135c95a4930ca |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-12-16T18:19:29Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-62fe62e77d6f45b7894135c95a4930ca2022-12-21T22:21:35ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492020-01-0142140040410.1080/0886022X.2020.17574631757463Day-to-day variation of the kidney proximal tubular injury markers urinary cystatin C, KIM1, and NGAL in patients with chronic kidney diseaseInga Soveri0Johanna Helmersson-Karlqvist1Bengt Fellström2Anders Larsson3Department of Medical Sciences, Uppsala University, Uppsala University HospitalDepartment of Medical Sciences, Uppsala University, Uppsala University HospitalDepartment of Medical Sciences, Uppsala University, Uppsala University HospitalDepartment of Medical Sciences, Uppsala University, Uppsala University HospitalBackground It is important to know the intraindividual variation of biomarkers to be able to distinguish a change of a biomarker due to the course of the disease from the normal biological variation of the marker. The purpose of this study was to investigate the day-to-day variability of urine markers in nephrology patients. Materials 23 nephrology patients were included in the study. First morning urine samples were collected daily for ten consecutive days and analyzed for U-cystatin C, U-KIM1, U-NGAL and U-creatinine. The day-to-day variation was calculated as concentrations of the markers and as creatinine ratios. Values deviating more than the 90th percentile of the normal intraindividual variation was used to define a disease/treatment specific change. Results The day-to-day coefficient of variation (CV) for individual patients varied between 9.6 and 100.3% for NGAL (mean 45.6%) and between 8.8 and 107.3% for the NGAL/creatinine ratio (mean 43.8%). The corresponding values for KIM1 were between 10.9 and 60.2% (mean 30.1%) and for the ratio between 8.7 and 59.8% (mean 23.4%) and for cystatin C 3.8–67.4% (mean 25.0%) and for the cystatin C/creatinine ratio 5.9–78.4% (mean 24.8%). Conclusions The similar intraindividual CV values between the renal tubules damage markers and their corresponding creatinine ratios speaks against using creatinine ratio. Using the 90th percentiles of the CV values as a limit for clinical change means that NGAL has to change by 83.3%, KIM1 by 45.5% and Cystatin C by 46.3% before the change can be considered clinically significant in patients with chronic kidney disease.http://dx.doi.org/10.1080/0886022X.2020.1757463u-kim1u-ngalu-cystatin cday-to-day variationproximal tubular injury markers |
| spellingShingle | Inga Soveri Johanna Helmersson-Karlqvist Bengt Fellström Anders Larsson Day-to-day variation of the kidney proximal tubular injury markers urinary cystatin C, KIM1, and NGAL in patients with chronic kidney disease Renal Failure u-kim1 u-ngal u-cystatin c day-to-day variation proximal tubular injury markers |
| title | Day-to-day variation of the kidney proximal tubular injury markers urinary cystatin C, KIM1, and NGAL in patients with chronic kidney disease |
| title_full | Day-to-day variation of the kidney proximal tubular injury markers urinary cystatin C, KIM1, and NGAL in patients with chronic kidney disease |
| title_fullStr | Day-to-day variation of the kidney proximal tubular injury markers urinary cystatin C, KIM1, and NGAL in patients with chronic kidney disease |
| title_full_unstemmed | Day-to-day variation of the kidney proximal tubular injury markers urinary cystatin C, KIM1, and NGAL in patients with chronic kidney disease |
| title_short | Day-to-day variation of the kidney proximal tubular injury markers urinary cystatin C, KIM1, and NGAL in patients with chronic kidney disease |
| title_sort | day to day variation of the kidney proximal tubular injury markers urinary cystatin c kim1 and ngal in patients with chronic kidney disease |
| topic | u-kim1 u-ngal u-cystatin c day-to-day variation proximal tubular injury markers |
| url | http://dx.doi.org/10.1080/0886022X.2020.1757463 |
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