Plasmid-mediated metronidazole resistance in Clostridioides difficile
Cases of C. difficile (CD) resistant to metronidazole have been reported but the mechanism remains enigmatic. Here the authors identify a plasmid, which correlates with metronidazole resistance status in a large international collection of CD isolates, and demonstrate that the plasmid can confer met...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-14382-1 |
| _version_ | 1818750474073931776 |
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| author | Ilse M. Boekhoud Bastian V. H. Hornung Eloisa Sevilla Céline Harmanus Ingrid M. J. G. Bos-Sanders Elisabeth M. Terveer Rosa Bolea Jeroen Corver Ed J. Kuijper Wiep Klaas Smits |
| author_facet | Ilse M. Boekhoud Bastian V. H. Hornung Eloisa Sevilla Céline Harmanus Ingrid M. J. G. Bos-Sanders Elisabeth M. Terveer Rosa Bolea Jeroen Corver Ed J. Kuijper Wiep Klaas Smits |
| author_sort | Ilse M. Boekhoud |
| collection | DOAJ |
| description | Cases of C. difficile (CD) resistant to metronidazole have been reported but the mechanism remains enigmatic. Here the authors identify a plasmid, which correlates with metronidazole resistance status in a large international collection of CD isolates, and demonstrate that the plasmid can confer metronidazole resistance. |
| first_indexed | 2024-12-18T04:20:15Z |
| format | Article |
| id | doaj.art-62feb273069b45dbbfbfc70da53d3cb5 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T04:20:15Z |
| publishDate | 2020-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-62feb273069b45dbbfbfc70da53d3cb52022-12-21T21:21:15ZengNature PortfolioNature Communications2041-17232020-01-0111111210.1038/s41467-020-14382-1Plasmid-mediated metronidazole resistance in Clostridioides difficileIlse M. Boekhoud0Bastian V. H. Hornung1Eloisa Sevilla2Céline Harmanus3Ingrid M. J. G. Bos-Sanders4Elisabeth M. Terveer5Rosa Bolea6Jeroen Corver7Ed J. Kuijper8Wiep Klaas Smits9Department of Medical Microbiology, Leiden University Medical CenterDepartment of Medical Microbiology, Leiden University Medical CenterDepartamento de Patología Animal, Facultad de Veterinaria, Universidad de ZaragozaDepartment of Medical Microbiology, Leiden University Medical CenterDepartment of Medical Microbiology, Leiden University Medical CenterDepartment of Medical Microbiology, Leiden University Medical CenterDepartamento de Patología Animal, Facultad de Veterinaria, Universidad de ZaragozaDepartment of Medical Microbiology, Leiden University Medical CenterDepartment of Medical Microbiology, Leiden University Medical CenterDepartment of Medical Microbiology, Leiden University Medical CenterCases of C. difficile (CD) resistant to metronidazole have been reported but the mechanism remains enigmatic. Here the authors identify a plasmid, which correlates with metronidazole resistance status in a large international collection of CD isolates, and demonstrate that the plasmid can confer metronidazole resistance.https://doi.org/10.1038/s41467-020-14382-1 |
| spellingShingle | Ilse M. Boekhoud Bastian V. H. Hornung Eloisa Sevilla Céline Harmanus Ingrid M. J. G. Bos-Sanders Elisabeth M. Terveer Rosa Bolea Jeroen Corver Ed J. Kuijper Wiep Klaas Smits Plasmid-mediated metronidazole resistance in Clostridioides difficile Nature Communications |
| title | Plasmid-mediated metronidazole resistance in Clostridioides difficile |
| title_full | Plasmid-mediated metronidazole resistance in Clostridioides difficile |
| title_fullStr | Plasmid-mediated metronidazole resistance in Clostridioides difficile |
| title_full_unstemmed | Plasmid-mediated metronidazole resistance in Clostridioides difficile |
| title_short | Plasmid-mediated metronidazole resistance in Clostridioides difficile |
| title_sort | plasmid mediated metronidazole resistance in clostridioides difficile |
| url | https://doi.org/10.1038/s41467-020-14382-1 |
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