Plasmid-mediated metronidazole resistance in Clostridioides difficile

Plasmid-mediated metronidazole resistance in Clostridioides difficile

Cases of C. difficile (CD) resistant to metronidazole have been reported but the mechanism remains enigmatic. Here the authors identify a plasmid, which correlates with metronidazole resistance status in a large international collection of CD isolates, and demonstrate that the plasmid can confer met...

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Bibliographic Details
Main Authors:	Ilse M. Boekhoud, Bastian V. H. Hornung, Eloisa Sevilla, Céline Harmanus, Ingrid M. J. G. Bos-Sanders, Elisabeth M. Terveer, Rosa Bolea, Jeroen Corver, Ed J. Kuijper, Wiep Klaas Smits
Format:	Article
Language:	English
Published:	Nature Portfolio 2020-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-14382-1

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