Electrophile-Induced Conformational Switch of the Human TRPA1 Ion Channel Detected by Mass Spectrometry

Electrophile-Induced Conformational Switch of the Human TRPA1 Ion Channel Detected by Mass Spectrometry

The human Transient Receptor Potential A1 (hTRPA1) ion channel, also known as the wasabi receptor, acts as a biosensor of various potentially harmful stimuli. It is activated by a wide range of chemicals, including the electrophilic compound N-methylmaleimide (NMM), but the mechanism of activation i...

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Bibliographic Details
Main Authors: Lavanya Moparthi, Sven Kjellström, Per Kjellbom, Milos R. Filipovic, Peter M. Zygmunt, Urban Johanson
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
TRP channel
TRPA1
wasabi receptor
electrophile sensing
<i>N</i>-methylmaleimide
iodoacetamide
Online Access:https://www.mdpi.com/1422-0067/21/18/6667

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