Molecular Mechanisms of Retinal Pigment Epithelium Dysfunction in Age-Related Macular Degeneration

Molecular Mechanisms of Retinal Pigment Epithelium Dysfunction in Age-Related Macular Degeneration

The retinal pigment epithelium (RPE), situated upon Bruch’s membrane, plays multiple roles in the ocular system by interacting with photoreceptors and. Therefore, dysfunction of the RPE causes diseases related to vision loss, such as age-related macular degeneration (AMD). Despite AMD being a global...

Full description

Bibliographic Details
Main Authors:	Jongmin Kim, Yeo Jin Lee, Jae Yon Won
Format:	Article
Language:	English
Published:	MDPI AG 2021-11-01
Series:	International Journal of Molecular Sciences
Subjects:	age-related macular degeneration retinal pigment epithelium
Online Access:	https://www.mdpi.com/1422-0067/22/22/12298

Similar Items

Effect of Photobiomodulation in Suppression of Oxidative Stress on Retinal Pigment Epithelium
by: Jongmin Kim, et al.
Published: (2022-06-01)

Inflammasome Activation in Retinal Pigment Epithelium from Human Donors with Age-Related Macular Degeneration
by: Mara C. Ebeling, et al.
Published: (2022-06-01)

Development of a CRISPRi Human Retinal Pigmented Epithelium Model for Functional Study of Age-Related Macular Degeneration Genes
by: Jiang-Hui Wang, et al.
Published: (2023-02-01)

Research progress of tight junction between retinal pigment epithelium cells and its disruption in the pathogenesis of age-related macular degeneration
by: Qiao-Yun Wang, et al.
Published: (2023-02-01)

Сlinical analysis of the series of A-VEGF therapy in patients with retinal pigment epithelium tear complicating of wet form age-related macular degeneration
by: E. V. Kozina, et al.
Published: (2021-10-01)

Human iPSC- and Primary-Retinal Pigment Epithelial Cells for Modeling Age-Related Macular Degeneration
by: Cody R. Fisher, et al.
Published: (2022-03-01)

Retinal Pigment Epithelium Expressed Toll-like Receptors and Their Potential Role in Age-Related Macular Degeneration
by: Alexa Klettner, et al.
Published: (2021-08-01)

Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration
by: Federica Storti, et al.
Published: (2019-03-01)

Old Problem in a New Guise: Retinal Pigment Epithelium Tear after Intravitreal Faricimab (Vabysmo®) Injection
by: Christoph R Clemens, et al.
Published: (2023-05-01)

Giant retinal pigment epithelium tears with membranous nephropathy: a case report and literature review
by: Rui Dou, et al.
Published: (2024-04-01)

Comparison of histologic findings in age-related macular degeneration with RPE flatmount images
by: Qing Zhang, et al.
Published: (2019-02-01)

The first experience of 3D spheroids retinal pigment epithelium transplantation in the experiment
by: S. A. Borzenok, et al.
Published: (2019-04-01)

Quantitative Proteomics of Human Retinal Pigment Epithelium Reveals Key Regulators for the Pathogenesis of Age-Related Macular Degeneration
by: Shichen Shen, et al.
Published: (2023-02-01)

The role of inflammation in age-related macular degeneration
by: Diana Florina Tricorache, et al.
Published: (2023-10-01)

Cytoprotective Potential of Fucoxanthin in Oxidative Stress-Induced Age-Related Macular Degeneration and Retinal Pigment Epithelial Cell Senescence In Vivo and In Vitro
by: Shiu-Jau Chen, et al.
Published: (2021-02-01)

Exploring the pathogenesis of age-related macular degeneration: A review of the interplay between retinal pigment epithelium dysfunction and the innate immune system
by: Josephine H. C. Wong, et al.
Published: (2022-11-01)

The development of transplantation technique of 3D spheroids retinal pigment epithelium in the experiment on animals
by: S. A. Borzenok, et al.
Published: (2019-07-01)

Chorioretinal thickness and retinal pigment epithelial degeneration of fellow eyes in patients with unilateral neovascular age-related macular degeneration with subretinal drusenoid deposits
by: Dongwan Kang, et al.
Published: (2022-07-01)

Foveal simple hamartoma of retinal pigment epithelium
by: Prabu Baskaran, et al.
Published: (2018-01-01)

Involvement of the Retinal Pigment Epithelium in the Development of Retinal Lattice Degeneration
by: Hiroshi Mizuno, et al.
Published: (2020-10-01)

Clinical Characteristics of Eyes with Neovascular Age-Related Macular Degeneration and Retinal Pigment Epithelium Tears
by: Junya Nagata, et al.
Published: (2023-08-01)

Retinal Pigment Epithelial and Outer Retinal Atrophy in Age-Related Macular Degeneration: Correlation with Macular Function
by: Maria C. Savastano, et al.
Published: (2020-09-01)

Zinc Supplementation Induced Transcriptional Changes in Primary Human Retinal Pigment Epithelium: A Single-Cell RNA Sequencing Study to Understand Age-Related Macular Degeneration
by: Eszter Emri, et al.
Published: (2023-02-01)

Transplantation of retinal pigment epithelium and photoreceptors generated concomitantly via small molecule-mediated differentiation rescues visual function in rodent models of retinal degeneration
by: Harshini Surendran, et al.
Published: (2021-01-01)

Retinal pigment epithelium degeneration caused by aggregation of PRPF31 and the role of HSP70 family of proteins
by: Lourdes Valdés-Sánchez, et al.
Published: (2019-12-01)

Effect of cytokeratin 17 on retinal pigment epithelium degeneration and choroidal neovascularization
by: Yi Shen, et al.
Published: (2016-03-01)

Improved effect of a mitochondria-targeted antioxidant on hydrogen peroxide-induced oxidative stress in human retinal pigment epithelium cells
by: Myung Hee Kim, et al.
Published: (2021-01-01)

Concentric retinal pigment epithelium tear in central serous chorioretinopathy
by: Darshana Daga, et al.
Published: (2019-01-01)

Eye-Light on Age-Related Macular Degeneration: Targeting Nrf2-Pathway as a Novel Therapeutic Strategy for Retinal Pigment Epithelium
by: Michele Catanzaro, et al.
Published: (2020-06-01)

Stem cell‐derived retinal pigment epithelium from patients with age‐related macular degeneration exhibit reduced metabolism and matrix interactions
by: Jie Gong, et al.
Published: (2020-03-01)

Review of graft rejection in age-related macular degeneration replacement therapy
by: Xi-Ying Mao, et al.
Published: (2016-02-01)

Impaired Mitochondrial Function in iPSC-Retinal Pigment Epithelium with the Complement Factor H Polymorphism for Age-Related Macular Degeneration
by: Mara C. Ebeling, et al.
Published: (2021-04-01)

Oxidation of DJ-1 Cysteines in Retinal Pigment Epithelium Function
by: Sanghamitra Bhattacharyya, et al.
Published: (2022-09-01)

Retinal pigment epithelium extracellular vesicles are potent inducers of age‐related macular degeneration disease phenotype in the outer retina
by: Marzena Kurzawa‐Akanbi, et al.
Published: (2022-12-01)

The retinal pigment epithelium in Sorsby Fundus Dystrophy shows increased sensitivity to oxidative stress-induced degeneration
by: Alyson Wolk, et al.
Published: (2020-10-01)

Human-induced pluripotent stem cells-derived retinal pigmented epithelium, a new horizon for cells-based therapies for age-related macular degeneration
by: Samaneh Dehghan, et al.
Published: (2022-05-01)

Common clinical features of unilateral retinal pigment epithelium dysgenesis and combined hamartoma of the retina and retinal pigment epithelium
by: Zhe Zhu, et al.
Published: (2022-01-01)

Dysfunctional Autophagy, Proteostasis, and Mitochondria as a Prelude to Age-Related Macular Degeneration
by: Raji Rajesh Lenin, et al.
Published: (2023-05-01)

Metabolomics and Age-Related Macular Degeneration
by: Connor N. Brown, et al.
Published: (2018-12-01)

Retinal Pigment Epithelium Cell Development: Extrapolating Basic Biology to Stem Cell Research
by: Santosh Gupta, et al.
Published: (2023-01-01)