Dose–response association between maternal pre-pregnancy bodyweight and gestational diabetes mellitus following ART treatment: a population-based cohort study
Abstract Background The impact of maternal pre-pregnancy bodyweight on gestational diabetes mellitus (GDM) following assisted reproductive technology (ART) treatment has been insufficiently investigated. The aim of this study was to investigate the association between maternal pre-pregnancy bodyweig...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | Reproductive Biology and Endocrinology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12958-022-00964-9 |
| _version_ | 1818550400584777728 |
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| author | Yiquan Xiong Jing Wang Yana Qi Chunrong Liu Mingxi Li Guanhua Yao Wei Sun Yongyao Qian Lishan Ye Hui Liu Qiushi Xu Kang Zou Jing Tan Xin Sun |
| author_facet | Yiquan Xiong Jing Wang Yana Qi Chunrong Liu Mingxi Li Guanhua Yao Wei Sun Yongyao Qian Lishan Ye Hui Liu Qiushi Xu Kang Zou Jing Tan Xin Sun |
| author_sort | Yiquan Xiong |
| collection | DOAJ |
| description | Abstract Background The impact of maternal pre-pregnancy bodyweight on gestational diabetes mellitus (GDM) following assisted reproductive technology (ART) treatment has been insufficiently investigated. The aim of this study was to investigate the association between maternal pre-pregnancy bodyweight and GDM following ART. Methods From January 2014 to March 2019, this population-based retrospective cohort study included pregnancies achieved by ART treatment in a pregnancy registration database in China. Multivariate regression analysis and restricted cubic splines were used to explore the association between bodyweight and GDM. Results A total of 6,598 pregnancies were included. The incidence of GDM was 26.0% (1715/6598). A total of 868 (13.2%) pregnant women were underweight, 665 (10.8%) were overweight, and 145 (2.20%) were obesity. We found a linear dose–response relation between maternal body mass index and GDM by restricted cubic splines, where one unit body mass index increase was associated with the 15% elevated risk of GDM (adjusted odds ratio [OR] 1.15, 95% CI 1.08–1.22). Compared to the normal weight group, maternal underweight was associated with lower risk of GDM (adjusted OR 0.68, 95% CI 0.57–0.82), while increased risk was found for overweight (adjusted OR 1.54 95% CI 1.29–1.84) and obesity (adjusted OR 1.74, 95% CI 1.23–2.47). Conclusions Our study found a linear dose–effect relationship between pre-pregnancy bodyweight and GDM following ART treatment. The findings in this study support the clinical recommendation of advising women with overweight or obesity to lose weight prior to ART treatment. |
| first_indexed | 2024-12-12T08:45:58Z |
| format | Article |
| id | doaj.art-630305a88d0347c3b0c62bec5640bf65 |
| institution | Directory Open Access Journal |
| issn | 1477-7827 |
| language | English |
| last_indexed | 2024-12-12T08:45:58Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Biology and Endocrinology |
| spelling | doaj.art-630305a88d0347c3b0c62bec5640bf652022-12-22T00:30:32ZengBMCReproductive Biology and Endocrinology1477-78272022-06-0120111010.1186/s12958-022-00964-9Dose–response association between maternal pre-pregnancy bodyweight and gestational diabetes mellitus following ART treatment: a population-based cohort studyYiquan Xiong0Jing Wang1Yana Qi2Chunrong Liu3Mingxi Li4Guanhua Yao5Wei Sun6Yongyao Qian7Lishan Ye8Hui Liu9Qiushi Xu10Kang Zou11Jing Tan12Xin Sun13Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan UniversityChinese Evidence-Based Medicine Center, West China Hospital, Sichuan UniversityChinese Evidence-Based Medicine Center, West China Hospital, Sichuan UniversityChinese Evidence-Based Medicine Center, West China Hospital, Sichuan UniversityChinese Evidence-Based Medicine Center, West China Hospital, Sichuan UniversityXiamen Health CommissionXiamen Health CommissionXiamen Health CommissionXiamen Health and Medical Big Data CenterXiamen Health and Medical Big Data CenterXiamen Health and Medical Big Data CenterChinese Evidence-Based Medicine Center, West China Hospital, Sichuan UniversityChinese Evidence-Based Medicine Center, West China Hospital, Sichuan UniversityChinese Evidence-Based Medicine Center, West China Hospital, Sichuan UniversityAbstract Background The impact of maternal pre-pregnancy bodyweight on gestational diabetes mellitus (GDM) following assisted reproductive technology (ART) treatment has been insufficiently investigated. The aim of this study was to investigate the association between maternal pre-pregnancy bodyweight and GDM following ART. Methods From January 2014 to March 2019, this population-based retrospective cohort study included pregnancies achieved by ART treatment in a pregnancy registration database in China. Multivariate regression analysis and restricted cubic splines were used to explore the association between bodyweight and GDM. Results A total of 6,598 pregnancies were included. The incidence of GDM was 26.0% (1715/6598). A total of 868 (13.2%) pregnant women were underweight, 665 (10.8%) were overweight, and 145 (2.20%) were obesity. We found a linear dose–response relation between maternal body mass index and GDM by restricted cubic splines, where one unit body mass index increase was associated with the 15% elevated risk of GDM (adjusted odds ratio [OR] 1.15, 95% CI 1.08–1.22). Compared to the normal weight group, maternal underweight was associated with lower risk of GDM (adjusted OR 0.68, 95% CI 0.57–0.82), while increased risk was found for overweight (adjusted OR 1.54 95% CI 1.29–1.84) and obesity (adjusted OR 1.74, 95% CI 1.23–2.47). Conclusions Our study found a linear dose–effect relationship between pre-pregnancy bodyweight and GDM following ART treatment. The findings in this study support the clinical recommendation of advising women with overweight or obesity to lose weight prior to ART treatment.https://doi.org/10.1186/s12958-022-00964-9Gestational diabetes mellitusBMIDose–response analysisAssisted reproductive technologyPopulation-based study |
| spellingShingle | Yiquan Xiong Jing Wang Yana Qi Chunrong Liu Mingxi Li Guanhua Yao Wei Sun Yongyao Qian Lishan Ye Hui Liu Qiushi Xu Kang Zou Jing Tan Xin Sun Dose–response association between maternal pre-pregnancy bodyweight and gestational diabetes mellitus following ART treatment: a population-based cohort study Reproductive Biology and Endocrinology Gestational diabetes mellitus BMI Dose–response analysis Assisted reproductive technology Population-based study |
| title | Dose–response association between maternal pre-pregnancy bodyweight and gestational diabetes mellitus following ART treatment: a population-based cohort study |
| title_full | Dose–response association between maternal pre-pregnancy bodyweight and gestational diabetes mellitus following ART treatment: a population-based cohort study |
| title_fullStr | Dose–response association between maternal pre-pregnancy bodyweight and gestational diabetes mellitus following ART treatment: a population-based cohort study |
| title_full_unstemmed | Dose–response association between maternal pre-pregnancy bodyweight and gestational diabetes mellitus following ART treatment: a population-based cohort study |
| title_short | Dose–response association between maternal pre-pregnancy bodyweight and gestational diabetes mellitus following ART treatment: a population-based cohort study |
| title_sort | dose response association between maternal pre pregnancy bodyweight and gestational diabetes mellitus following art treatment a population based cohort study |
| topic | Gestational diabetes mellitus BMI Dose–response analysis Assisted reproductive technology Population-based study |
| url | https://doi.org/10.1186/s12958-022-00964-9 |
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