Efficacy of Chinese herbal medicine in functional dyspepsia: A meta-analysis of randomized, double-blind, placebo-controlled trials
Objective: To evaluate the efficacy and safety of Chinese herbal medicine (CHM) for the treatment of functional dyspepsia (FD). Methods: Web of Science, PubMed, EMBASE, Cochrane Library, and four other Chinese electronic databases, including China National Knowledge Infrastructure (CNKI), Chinese Bi...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-07-01
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| Series: | Journal of Traditional Chinese Medical Sciences |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S209575481630076X |
| _version_ | 1827848101846581248 |
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| author | Yu Guo Jiajie Zhu Xiaolan Su Jianqin Yang Yijie Li Qingguo Wang Wei Wei |
| author_facet | Yu Guo Jiajie Zhu Xiaolan Su Jianqin Yang Yijie Li Qingguo Wang Wei Wei |
| author_sort | Yu Guo |
| collection | DOAJ |
| description | Objective: To evaluate the efficacy and safety of Chinese herbal medicine (CHM) for the treatment of functional dyspepsia (FD).
Methods: Web of Science, PubMed, EMBASE, Cochrane Library, and four other Chinese electronic databases, including China National Knowledge Infrastructure (CNKI), Chinese Biological Medical Database (CBM), Chinese Scientific Journals Database (VIP), and WanFang Database were used to search (up to Feb, 2016) for randomized, double-blind, placebo-controlled trials recruiting adults with FD treated with CHM. Study selection, data extraction, quality assessment, and data analyses were conducted based on Cochrane standards using Review Manager software.
Results: Fourteen publications (1424 patients) were included. Evidence revealed that CHM was more efficacious than the placebo in improving global dyspepsia symptoms (RR, 1.45; 95% CI, 1.31–1.60), Chinese medicine syndrome (CMS) (RR, 1.36; 95% CI, 1.23–1.50), and quality of life (SMD, 0.30; 95% CI, 0.15–0.45) in FD patients. Furthermore, the difference in the incidence of adverse events between CHM and placebo groups had no statistical significance (RR, 1.06; 95% CI, 0.66–1.70).
Conclusion: This meta-analysis demonstrates that CHM has a therapeutic potential in treating FD with a certain safety. However, due to the restricted number of trials included, well-planned, long-term studies are necessary to provide credible evidence. |
| first_indexed | 2024-03-12T09:41:13Z |
| format | Article |
| id | doaj.art-630445e73f044f93bdf7d1cc6e3411d1 |
| institution | Directory Open Access Journal |
| issn | 2095-7548 |
| language | English |
| last_indexed | 2024-03-12T09:41:13Z |
| publishDate | 2016-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Traditional Chinese Medical Sciences |
| spelling | doaj.art-630445e73f044f93bdf7d1cc6e3411d12023-09-02T13:13:54ZengElsevierJournal of Traditional Chinese Medical Sciences2095-75482016-07-013314715610.1016/j.jtcms.2016.09.006Efficacy of Chinese herbal medicine in functional dyspepsia: A meta-analysis of randomized, double-blind, placebo-controlled trialsYu Guo0Jiajie Zhu1Xiaolan Su2Jianqin Yang3Yijie Li4Qingguo Wang5Wei Wei6Beijing University of Chinese Medicine, Beijing 10029, ChinaBeijing University of Chinese Medicine, Beijing 10029, ChinaDepartment of Gastroenterology, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing 10102, ChinaDepartment of Gastroenterology, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing 10102, ChinaBeijing University of Chinese Medicine, Beijing 10029, ChinaBeijing University of Chinese Medicine, Beijing 10029, ChinaDepartment of Gastroenterology, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing 10102, ChinaObjective: To evaluate the efficacy and safety of Chinese herbal medicine (CHM) for the treatment of functional dyspepsia (FD). Methods: Web of Science, PubMed, EMBASE, Cochrane Library, and four other Chinese electronic databases, including China National Knowledge Infrastructure (CNKI), Chinese Biological Medical Database (CBM), Chinese Scientific Journals Database (VIP), and WanFang Database were used to search (up to Feb, 2016) for randomized, double-blind, placebo-controlled trials recruiting adults with FD treated with CHM. Study selection, data extraction, quality assessment, and data analyses were conducted based on Cochrane standards using Review Manager software. Results: Fourteen publications (1424 patients) were included. Evidence revealed that CHM was more efficacious than the placebo in improving global dyspepsia symptoms (RR, 1.45; 95% CI, 1.31–1.60), Chinese medicine syndrome (CMS) (RR, 1.36; 95% CI, 1.23–1.50), and quality of life (SMD, 0.30; 95% CI, 0.15–0.45) in FD patients. Furthermore, the difference in the incidence of adverse events between CHM and placebo groups had no statistical significance (RR, 1.06; 95% CI, 0.66–1.70). Conclusion: This meta-analysis demonstrates that CHM has a therapeutic potential in treating FD with a certain safety. However, due to the restricted number of trials included, well-planned, long-term studies are necessary to provide credible evidence.http://www.sciencedirect.com/science/article/pii/S209575481630076XFunctional dyspepsiaMeta-analysisChinese herbal medicinePlacebo |
| spellingShingle | Yu Guo Jiajie Zhu Xiaolan Su Jianqin Yang Yijie Li Qingguo Wang Wei Wei Efficacy of Chinese herbal medicine in functional dyspepsia: A meta-analysis of randomized, double-blind, placebo-controlled trials Journal of Traditional Chinese Medical Sciences Functional dyspepsia Meta-analysis Chinese herbal medicine Placebo |
| title | Efficacy of Chinese herbal medicine in functional dyspepsia: A meta-analysis of randomized, double-blind, placebo-controlled trials |
| title_full | Efficacy of Chinese herbal medicine in functional dyspepsia: A meta-analysis of randomized, double-blind, placebo-controlled trials |
| title_fullStr | Efficacy of Chinese herbal medicine in functional dyspepsia: A meta-analysis of randomized, double-blind, placebo-controlled trials |
| title_full_unstemmed | Efficacy of Chinese herbal medicine in functional dyspepsia: A meta-analysis of randomized, double-blind, placebo-controlled trials |
| title_short | Efficacy of Chinese herbal medicine in functional dyspepsia: A meta-analysis of randomized, double-blind, placebo-controlled trials |
| title_sort | efficacy of chinese herbal medicine in functional dyspepsia a meta analysis of randomized double blind placebo controlled trials |
| topic | Functional dyspepsia Meta-analysis Chinese herbal medicine Placebo |
| url | http://www.sciencedirect.com/science/article/pii/S209575481630076X |
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