Primary squamous cell carcinoma of thyroid gland: 11 case reports and a population-based study
Abstract Background Primary squamous cell carcinoma of thyroid gland (PSCCT) is a highly aggressive malignant tumor associated with a poor prognosis. Due to the rare case, there is a knowledge gap on the features of PSCCT. There is limited understanding of the treatment and molecular biology of this...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-11-01
|
| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12957-022-02814-9 |
| _version_ | 1797984671751995392 |
|---|---|
| author | Wanyun Yan Huiying Chen Jiangmiao Li Ruifa Zhou Jiping Su |
| author_facet | Wanyun Yan Huiying Chen Jiangmiao Li Ruifa Zhou Jiping Su |
| author_sort | Wanyun Yan |
| collection | DOAJ |
| description | Abstract Background Primary squamous cell carcinoma of thyroid gland (PSCCT) is a highly aggressive malignant tumor associated with a poor prognosis. Due to the rare case, there is a knowledge gap on the features of PSCCT. There is limited understanding of the treatment and molecular biology of this tumor. More genomic work and relevant perspective work need to be done. Methods We retrospectively reviewed the medical information of patients with PSCCT diagnosed from December 2009 to December 2020 at The First Affiliated Hospital of Guangxi Medical University. In addition, we conducted an electronic search of the paper in CNKI, Wanfang, VIP, PubMed, Embase, Web of Science, and ProQuest databases by recently updated articles. Survival analysis was conducted using the Kaplan–Meier method. Results There were only 11 patients met the study’s inclusion criteria in our institution. The patients ranged in age from 25 to 68 years old and female preponderance (M:F = 1:1.7). The median survival time was 6 months, and 1-year survival rate was 33.3%. Fifty-three patients’ individual data from 45 articles were selected for analysis. The median age at diagnosis was 63 years and female preponderance (M:F = 1:2.5). The commonest complaint was the anterior neck mass (77.3%), followed by hoarseness (32.1%). The median survival time was 9 months, and the overall 1-, 2-, and 5-year survival rate was 39.8%, 33.7%, and 26.9%, respectively. The log-rank method shows that age, tumor size, lymph node status, M stage, surgical range, and tracheal status were the relevant factors affecting the prognosis. In contrast, gender, treatment modality, and resection margin were not prognostic factors. On multivariable analysis, age and M stage were associated with overall survival. Conclusion The median overall survival was 6–9 months of PSCCT. Age and M stage are predictors of PSSCT. |
| first_indexed | 2024-04-11T07:05:41Z |
| format | Article |
| id | doaj.art-63057141a71843439f1fdfcd2c2bb7dc |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-04-11T07:05:41Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-63057141a71843439f1fdfcd2c2bb7dc2022-12-22T04:38:23ZengBMCWorld Journal of Surgical Oncology1477-78192022-11-0120111110.1186/s12957-022-02814-9Primary squamous cell carcinoma of thyroid gland: 11 case reports and a population-based studyWanyun Yan0Huiying Chen1Jiangmiao Li2Ruifa Zhou3Jiping Su4Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Guangxi Medical UniversityDepartment of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Guangxi Medical UniversityDepartment of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Guangxi Medical UniversityDepartment of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Guangxi Medical UniversityDepartment of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Guangxi Medical UniversityAbstract Background Primary squamous cell carcinoma of thyroid gland (PSCCT) is a highly aggressive malignant tumor associated with a poor prognosis. Due to the rare case, there is a knowledge gap on the features of PSCCT. There is limited understanding of the treatment and molecular biology of this tumor. More genomic work and relevant perspective work need to be done. Methods We retrospectively reviewed the medical information of patients with PSCCT diagnosed from December 2009 to December 2020 at The First Affiliated Hospital of Guangxi Medical University. In addition, we conducted an electronic search of the paper in CNKI, Wanfang, VIP, PubMed, Embase, Web of Science, and ProQuest databases by recently updated articles. Survival analysis was conducted using the Kaplan–Meier method. Results There were only 11 patients met the study’s inclusion criteria in our institution. The patients ranged in age from 25 to 68 years old and female preponderance (M:F = 1:1.7). The median survival time was 6 months, and 1-year survival rate was 33.3%. Fifty-three patients’ individual data from 45 articles were selected for analysis. The median age at diagnosis was 63 years and female preponderance (M:F = 1:2.5). The commonest complaint was the anterior neck mass (77.3%), followed by hoarseness (32.1%). The median survival time was 9 months, and the overall 1-, 2-, and 5-year survival rate was 39.8%, 33.7%, and 26.9%, respectively. The log-rank method shows that age, tumor size, lymph node status, M stage, surgical range, and tracheal status were the relevant factors affecting the prognosis. In contrast, gender, treatment modality, and resection margin were not prognostic factors. On multivariable analysis, age and M stage were associated with overall survival. Conclusion The median overall survival was 6–9 months of PSCCT. Age and M stage are predictors of PSSCT.https://doi.org/10.1186/s12957-022-02814-9Primary thyroid tumorSquamous cell carcinomaPrognosisCase reportClinical features |
| spellingShingle | Wanyun Yan Huiying Chen Jiangmiao Li Ruifa Zhou Jiping Su Primary squamous cell carcinoma of thyroid gland: 11 case reports and a population-based study World Journal of Surgical Oncology Primary thyroid tumor Squamous cell carcinoma Prognosis Case report Clinical features |
| title | Primary squamous cell carcinoma of thyroid gland: 11 case reports and a population-based study |
| title_full | Primary squamous cell carcinoma of thyroid gland: 11 case reports and a population-based study |
| title_fullStr | Primary squamous cell carcinoma of thyroid gland: 11 case reports and a population-based study |
| title_full_unstemmed | Primary squamous cell carcinoma of thyroid gland: 11 case reports and a population-based study |
| title_short | Primary squamous cell carcinoma of thyroid gland: 11 case reports and a population-based study |
| title_sort | primary squamous cell carcinoma of thyroid gland 11 case reports and a population based study |
| topic | Primary thyroid tumor Squamous cell carcinoma Prognosis Case report Clinical features |
| url | https://doi.org/10.1186/s12957-022-02814-9 |
| work_keys_str_mv | AT wanyunyan primarysquamouscellcarcinomaofthyroidgland11casereportsandapopulationbasedstudy AT huiyingchen primarysquamouscellcarcinomaofthyroidgland11casereportsandapopulationbasedstudy AT jiangmiaoli primarysquamouscellcarcinomaofthyroidgland11casereportsandapopulationbasedstudy AT ruifazhou primarysquamouscellcarcinomaofthyroidgland11casereportsandapopulationbasedstudy AT jipingsu primarysquamouscellcarcinomaofthyroidgland11casereportsandapopulationbasedstudy |