Gold nanoparticles as cell regulators: beneficial effects of gold nanoparticles on the metabolic profile of mice with pre-existing obesity
Abstract Background We have previously shown that intraperitoneal injection of gold nanoparticles (AuNPs, 20–30 nm) into mice, decreases high-fat diet (HFD) induced weight gain and glucose intolerance, via suppression of inflammatory responses in both fat and liver tissues. This study investigates w...
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| Format: | Article |
| Language: | English |
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BMC
2018-11-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12951-018-0414-6 |
| _version_ | 1828112892652683264 |
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| author | Hui Chen Jane P. M. Ng David P. Bishop Bruce K. Milthorpe Stella M. Valenzuela |
| author_facet | Hui Chen Jane P. M. Ng David P. Bishop Bruce K. Milthorpe Stella M. Valenzuela |
| author_sort | Hui Chen |
| collection | DOAJ |
| description | Abstract Background We have previously shown that intraperitoneal injection of gold nanoparticles (AuNPs, 20–30 nm) into mice, decreases high-fat diet (HFD) induced weight gain and glucose intolerance, via suppression of inflammatory responses in both fat and liver tissues. This study investigates whether AuNPs provide similar benefit to mice with pre-existing obesity. Male C57BL/6 mice were fed a HFD for 15 weeks. AuNPs (OB-EAu 0.0785 μg/g/day, OB-LAu 0.785 μg/g/day, OB-HAu7.85 μg/g/day, ip) were administered to subgroups of HFD-fed mice over the last 5 weeks. Control group was fed standard chow and administered vehicle injection. Results Only the OB-LAu group demonstrated significant weight loss (12%), while all AuNP treated groups showed improved glycaemic control and reduced blood lipid levels. In the fat tissue, mRNA expression of pro-inflammatory markers were unchanged following AuNP treatment, while glucose and lipid metabolic markers were improved in OB-LAu and OB-HAu mice. In the liver, AuNP treatment downregulated inflammatory markers and improved lipid metabolic markers, with marked effects in OB-EAu and OB-LAu groups. Conclusions AuNP treatment can improve glucose and fat metabolism in mice with long-term obesity, however weight loss was only observed in a single specific dose regime. AuNP therapy is a promising new technology for managing metabolic disorders in the obese. |
| first_indexed | 2024-04-11T11:57:23Z |
| format | Article |
| id | doaj.art-6305ee4aee5c42cd93833de036e73cc0 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-11T11:57:23Z |
| publishDate | 2018-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-6305ee4aee5c42cd93833de036e73cc02022-12-22T04:25:05ZengBMCJournal of Nanobiotechnology1477-31552018-11-0116111310.1186/s12951-018-0414-6Gold nanoparticles as cell regulators: beneficial effects of gold nanoparticles on the metabolic profile of mice with pre-existing obesityHui Chen0Jane P. M. Ng1David P. Bishop2Bruce K. Milthorpe3Stella M. Valenzuela4School of Life Sciences, Faculty of Science, University of Technology SydneySchool of Life Sciences, Faculty of Science, University of Technology SydneySchool of Mathematical and Physical Sciences, University of Technology SydneySchool of Life Sciences, Faculty of Science, University of Technology SydneySchool of Life Sciences, Faculty of Science, University of Technology SydneyAbstract Background We have previously shown that intraperitoneal injection of gold nanoparticles (AuNPs, 20–30 nm) into mice, decreases high-fat diet (HFD) induced weight gain and glucose intolerance, via suppression of inflammatory responses in both fat and liver tissues. This study investigates whether AuNPs provide similar benefit to mice with pre-existing obesity. Male C57BL/6 mice were fed a HFD for 15 weeks. AuNPs (OB-EAu 0.0785 μg/g/day, OB-LAu 0.785 μg/g/day, OB-HAu7.85 μg/g/day, ip) were administered to subgroups of HFD-fed mice over the last 5 weeks. Control group was fed standard chow and administered vehicle injection. Results Only the OB-LAu group demonstrated significant weight loss (12%), while all AuNP treated groups showed improved glycaemic control and reduced blood lipid levels. In the fat tissue, mRNA expression of pro-inflammatory markers were unchanged following AuNP treatment, while glucose and lipid metabolic markers were improved in OB-LAu and OB-HAu mice. In the liver, AuNP treatment downregulated inflammatory markers and improved lipid metabolic markers, with marked effects in OB-EAu and OB-LAu groups. Conclusions AuNP treatment can improve glucose and fat metabolism in mice with long-term obesity, however weight loss was only observed in a single specific dose regime. AuNP therapy is a promising new technology for managing metabolic disorders in the obese.http://link.springer.com/article/10.1186/s12951-018-0414-6Gold nanoparticlesInflammationLiverObesityMetabolism |
| spellingShingle | Hui Chen Jane P. M. Ng David P. Bishop Bruce K. Milthorpe Stella M. Valenzuela Gold nanoparticles as cell regulators: beneficial effects of gold nanoparticles on the metabolic profile of mice with pre-existing obesity Journal of Nanobiotechnology Gold nanoparticles Inflammation Liver Obesity Metabolism |
| title | Gold nanoparticles as cell regulators: beneficial effects of gold nanoparticles on the metabolic profile of mice with pre-existing obesity |
| title_full | Gold nanoparticles as cell regulators: beneficial effects of gold nanoparticles on the metabolic profile of mice with pre-existing obesity |
| title_fullStr | Gold nanoparticles as cell regulators: beneficial effects of gold nanoparticles on the metabolic profile of mice with pre-existing obesity |
| title_full_unstemmed | Gold nanoparticles as cell regulators: beneficial effects of gold nanoparticles on the metabolic profile of mice with pre-existing obesity |
| title_short | Gold nanoparticles as cell regulators: beneficial effects of gold nanoparticles on the metabolic profile of mice with pre-existing obesity |
| title_sort | gold nanoparticles as cell regulators beneficial effects of gold nanoparticles on the metabolic profile of mice with pre existing obesity |
| topic | Gold nanoparticles Inflammation Liver Obesity Metabolism |
| url | http://link.springer.com/article/10.1186/s12951-018-0414-6 |
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