Facile Synthesis and Cytotoxic Activity of the First Ferrocene-Resveratrol Conjugate
The bioorganometallic <b>III</b> containing trimethylene chain between ferrocene and resveratrol (3,5,4'-trihydroxystilbene, <b>RSV</b>) moieties connected <i>via</i> ester bond has been synthesized. The novel bioconjugate was characterized using IR and NMR (...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Croatian Chemical Society
2016-09-01
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| Series: | Croatica Chemica Acta |
| Online Access: | http://hrcak.srce.hr/file/250062 |
| Summary: | The bioorganometallic <b>III</b> containing trimethylene chain between ferrocene and resveratrol (3,5,4'-trihydroxystilbene, <b>RSV</b>) moieties connected <i>via</i> ester bond has been synthesized. The novel bioconjugate was characterized using IR and NMR (<sup>1</sup>H, <sup>13</sup>C, COSY, NOESY, HMBC) spectroscopy, ESI-MS and HRMS. The <b>RSV</b> and ferrocene-<b>RSV</b> conjugate <b>III</b> were screened <i>in vitro</i> for their inhibitory effects against proliferation of hepatoblastoma (Hep G2) cells by MTT assay. Also, possible cytotoxicity towards normal ovary cells (CHO-K1) was evaluated. The obtained data revealed profound effects in biological/cytotoxic activity of <b>III</b> <i>vs</i>. <b>RSV</b> in Hep G2 cell line. Lower cytotoxicity of <b>III</b> was observed in normal ovary cells as compared to hepatoblastoma cells.
<br><a rel="license" href="http://creativecommons.org/licenses/by/4.0/"><img alt="Creative Commons License" style="border-width:0" src="https://i.creativecommons.org/l/by/4.0/80x15.png" /></a> This work is licensed under a <a rel="license" href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International License</a>. |
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| ISSN: | 0011-1643 1334-417X |