Facile Synthesis and Cytotoxic Activity of the First Ferrocene-Resveratrol Conjugate
The bioorganometallic <b>III</b> containing trimethylene chain between ferrocene and resveratrol (3,5,4'-trihydroxystilbene, <b>RSV</b>) moieties connected <i>via</i> ester bond has been synthesized. The novel bioconjugate was characterized using IR and NMR (...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Croatian Chemical Society
2016-09-01
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| Series: | Croatica Chemica Acta |
| Online Access: | http://hrcak.srce.hr/file/250062 |
| _version_ | 1811200361467215872 |
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| author | Veronika Kovač Ivana Kmetič Teuta Murati Marina Miletić Lidija Barišić |
| author_facet | Veronika Kovač Ivana Kmetič Teuta Murati Marina Miletić Lidija Barišić |
| author_sort | Veronika Kovač |
| collection | DOAJ |
| description | The bioorganometallic <b>III</b> containing trimethylene chain between ferrocene and resveratrol (3,5,4'-trihydroxystilbene, <b>RSV</b>) moieties connected <i>via</i> ester bond has been synthesized. The novel bioconjugate was characterized using IR and NMR (<sup>1</sup>H, <sup>13</sup>C, COSY, NOESY, HMBC) spectroscopy, ESI-MS and HRMS. The <b>RSV</b> and ferrocene-<b>RSV</b> conjugate <b>III</b> were screened <i>in vitro</i> for their inhibitory effects against proliferation of hepatoblastoma (Hep G2) cells by MTT assay. Also, possible cytotoxicity towards normal ovary cells (CHO-K1) was evaluated. The obtained data revealed profound effects in biological/cytotoxic activity of <b>III</b> <i>vs</i>. <b>RSV</b> in Hep G2 cell line. Lower cytotoxicity of <b>III</b> was observed in normal ovary cells as compared to hepatoblastoma cells.
<br><a rel="license" href="http://creativecommons.org/licenses/by/4.0/"><img alt="Creative Commons License" style="border-width:0" src="https://i.creativecommons.org/l/by/4.0/80x15.png" /></a> This work is licensed under a <a rel="license" href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International License</a>. |
| first_indexed | 2024-04-12T02:03:34Z |
| format | Article |
| id | doaj.art-6306d4cda9784c4c9229fa1c55bf008e |
| institution | Directory Open Access Journal |
| issn | 0011-1643 1334-417X |
| language | English |
| last_indexed | 2024-04-12T02:03:34Z |
| publishDate | 2016-09-01 |
| publisher | Croatian Chemical Society |
| record_format | Article |
| series | Croatica Chemica Acta |
| spelling | doaj.art-6306d4cda9784c4c9229fa1c55bf008e2022-12-22T03:52:37ZengCroatian Chemical SocietyCroatica Chemica Acta0011-16431334-417X2016-09-0189333934310.5562/cca2992169468Facile Synthesis and Cytotoxic Activity of the First Ferrocene-Resveratrol ConjugateVeronika Kovač0Ivana Kmetič1Teuta Murati2Marina Miletić3Lidija Barišić4Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, HR-10000 Zagreb, CroatiaDepartment of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, HR-10000 Zagreb, CroatiaDepartment of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, HR-10000 Zagreb, CroatiaDepartment of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, HR-10000 Zagreb, CroatiaDepartment of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, HR-10000 Zagreb, CroatiaThe bioorganometallic <b>III</b> containing trimethylene chain between ferrocene and resveratrol (3,5,4'-trihydroxystilbene, <b>RSV</b>) moieties connected <i>via</i> ester bond has been synthesized. The novel bioconjugate was characterized using IR and NMR (<sup>1</sup>H, <sup>13</sup>C, COSY, NOESY, HMBC) spectroscopy, ESI-MS and HRMS. The <b>RSV</b> and ferrocene-<b>RSV</b> conjugate <b>III</b> were screened <i>in vitro</i> for their inhibitory effects against proliferation of hepatoblastoma (Hep G2) cells by MTT assay. Also, possible cytotoxicity towards normal ovary cells (CHO-K1) was evaluated. The obtained data revealed profound effects in biological/cytotoxic activity of <b>III</b> <i>vs</i>. <b>RSV</b> in Hep G2 cell line. Lower cytotoxicity of <b>III</b> was observed in normal ovary cells as compared to hepatoblastoma cells. <br><a rel="license" href="http://creativecommons.org/licenses/by/4.0/"><img alt="Creative Commons License" style="border-width:0" src="https://i.creativecommons.org/l/by/4.0/80x15.png" /></a> This work is licensed under a <a rel="license" href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International License</a>.http://hrcak.srce.hr/file/250062 |
| spellingShingle | Veronika Kovač Ivana Kmetič Teuta Murati Marina Miletić Lidija Barišić Facile Synthesis and Cytotoxic Activity of the First Ferrocene-Resveratrol Conjugate Croatica Chemica Acta |
| title | Facile Synthesis and Cytotoxic Activity of the First Ferrocene-Resveratrol Conjugate |
| title_full | Facile Synthesis and Cytotoxic Activity of the First Ferrocene-Resveratrol Conjugate |
| title_fullStr | Facile Synthesis and Cytotoxic Activity of the First Ferrocene-Resveratrol Conjugate |
| title_full_unstemmed | Facile Synthesis and Cytotoxic Activity of the First Ferrocene-Resveratrol Conjugate |
| title_short | Facile Synthesis and Cytotoxic Activity of the First Ferrocene-Resveratrol Conjugate |
| title_sort | facile synthesis and cytotoxic activity of the first ferrocene resveratrol conjugate |
| url | http://hrcak.srce.hr/file/250062 |
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