Genetic polymorphisms of exon 1 of MBL2 contribute to tuberculosis risk especially in Asian populations: an updated meta-analysis of 26 studies
Yu-jiao Wu,1,* Xin Yang,2,* Ting-di Chen,3 Zhi-xin Zhang,4 Yi-zhong You,5 Zheng-da Fan1 1Department of Pharmacy, The Third People’s Hospital, Changzhou, China; 2Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, China; 3Department of Science and Educati...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018-08-01
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| Series: | Infection and Drug Resistance |
| Subjects: | |
| Online Access: | https://www.dovepress.com/genetic-polymorphisms-of-exon-1-of-mbl2-contribute-to-tuberculosis-ris-peer-reviewed-article-IDR |
| _version_ | 1818191883443109888 |
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| author | Wu YJ Yang X Chen TD Zhang ZX You YZ Fan ZD |
| author_facet | Wu YJ Yang X Chen TD Zhang ZX You YZ Fan ZD |
| author_sort | Wu YJ |
| collection | DOAJ |
| description | Yu-jiao Wu,1,* Xin Yang,2,* Ting-di Chen,3 Zhi-xin Zhang,4 Yi-zhong You,5 Zheng-da Fan1 1Department of Pharmacy, The Third People’s Hospital, Changzhou, China; 2Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, China; 3Department of Science and Education, The Third People’s Hospital, Changzhou, China; 4Department of Pulmonary Tuberculosis, The Third People’s Hospital, Changzhou, China; 5Department of Pharmacy, The Third Affiliated Hospital of Soochow University, Changzhou, China *These authors contributed equally to this work Background: Evidence suggests that genetic variations of exon 1 of mannose-binding lectin 2 (MBL2) may contribute to tuberculosis (TB) risk. Many studies have investigated the association between MBL2 exon 1 polymorphisms (rs1800450, rs1800451, and rs5030737) and TB risk, but yielded inconclusive results. Method: We conducted this meta-analysis of 26 eligible case–control studies that included 7952 cases and 9328 controls to identify the strength of association. Odds ratio (OR) and 95% CI were used to evaluate the strength of association. Statistical analyses were performed by using STATA 12.1.Results: We found a statistically significant correlation between MBL2 exon 1 polymorphisms and increased TB risk among three models: allele model (O vs A: OR =1.18, 95% CI: 1.01–1.38, Pheterogeneity<0.0001, I2=85.8%), homozygote comparison (OO vs AA: OR =1.49, 95%CI: 1.02–2.18, Pheterogeneity<0.0001, I2=79.1%), dominant model (AO/OO vs AA: OR =1.20, 95% CI: 1.01–1.43, Pheterogeneity<0.0001, I2=83.5%), especially in studies based on Asian populations among five models: allele model (O vs A: OR =1.29, 95% CI: 1.11–1.51, Pheterogeneity<0.0001, I2=66.0%), homozygote comparison (OO vs AA: OR =1.67, 95% CI: 1.09–2.55, Pheterogeneity=0.008, I2=54.2%), heterozygote comparison (AO vs AA: OR =1.26, 95% CI: 1.05–1.50, Pheterogeneity=0.001, I2=62.9%), dominant model (AO/OO vs. AA: OR =1.31, 95% CI: 1.10–1.56, Pheterogeneity=0.001, I2=64.2%), and recessive model (OO vs AO/AA: OR =1.50, 95% CI: 1.01–2.22, Pheterogeneity=0.023, I2=48.0%). Meta-regression results revealed that source of controls (p=0.009), but not ethnicity (p=0.687), genotyping method (p=0.231), and sample size (p=0.451) contributed to the source of heterogeneity.Conclusion: This meta-analysis suggests that MBL2 exon 1 polymorphisms may contribute to TB risk, especially in Asian populations. Keywords: MBL2, rs1800450, rs1800451, rs5030737, tuberculosis, polymorphisms |
| first_indexed | 2024-12-12T00:21:41Z |
| format | Article |
| id | doaj.art-63080a44f886493b97149c87633933ef |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-12-12T00:21:41Z |
| publishDate | 2018-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-63080a44f886493b97149c87633933ef2022-12-22T00:44:43ZengDove Medical PressInfection and Drug Resistance1178-69732018-08-01Volume 111237124839954Genetic polymorphisms of exon 1 of MBL2 contribute to tuberculosis risk especially in Asian populations: an updated meta-analysis of 26 studiesWu YJYang XChen TDZhang ZXYou YZFan ZDYu-jiao Wu,1,* Xin Yang,2,* Ting-di Chen,3 Zhi-xin Zhang,4 Yi-zhong You,5 Zheng-da Fan1 1Department of Pharmacy, The Third People’s Hospital, Changzhou, China; 2Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, China; 3Department of Science and Education, The Third People’s Hospital, Changzhou, China; 4Department of Pulmonary Tuberculosis, The Third People’s Hospital, Changzhou, China; 5Department of Pharmacy, The Third Affiliated Hospital of Soochow University, Changzhou, China *These authors contributed equally to this work Background: Evidence suggests that genetic variations of exon 1 of mannose-binding lectin 2 (MBL2) may contribute to tuberculosis (TB) risk. Many studies have investigated the association between MBL2 exon 1 polymorphisms (rs1800450, rs1800451, and rs5030737) and TB risk, but yielded inconclusive results. Method: We conducted this meta-analysis of 26 eligible case–control studies that included 7952 cases and 9328 controls to identify the strength of association. Odds ratio (OR) and 95% CI were used to evaluate the strength of association. Statistical analyses were performed by using STATA 12.1.Results: We found a statistically significant correlation between MBL2 exon 1 polymorphisms and increased TB risk among three models: allele model (O vs A: OR =1.18, 95% CI: 1.01–1.38, Pheterogeneity<0.0001, I2=85.8%), homozygote comparison (OO vs AA: OR =1.49, 95%CI: 1.02–2.18, Pheterogeneity<0.0001, I2=79.1%), dominant model (AO/OO vs AA: OR =1.20, 95% CI: 1.01–1.43, Pheterogeneity<0.0001, I2=83.5%), especially in studies based on Asian populations among five models: allele model (O vs A: OR =1.29, 95% CI: 1.11–1.51, Pheterogeneity<0.0001, I2=66.0%), homozygote comparison (OO vs AA: OR =1.67, 95% CI: 1.09–2.55, Pheterogeneity=0.008, I2=54.2%), heterozygote comparison (AO vs AA: OR =1.26, 95% CI: 1.05–1.50, Pheterogeneity=0.001, I2=62.9%), dominant model (AO/OO vs. AA: OR =1.31, 95% CI: 1.10–1.56, Pheterogeneity=0.001, I2=64.2%), and recessive model (OO vs AO/AA: OR =1.50, 95% CI: 1.01–2.22, Pheterogeneity=0.023, I2=48.0%). Meta-regression results revealed that source of controls (p=0.009), but not ethnicity (p=0.687), genotyping method (p=0.231), and sample size (p=0.451) contributed to the source of heterogeneity.Conclusion: This meta-analysis suggests that MBL2 exon 1 polymorphisms may contribute to TB risk, especially in Asian populations. Keywords: MBL2, rs1800450, rs1800451, rs5030737, tuberculosis, polymorphismshttps://www.dovepress.com/genetic-polymorphisms-of-exon-1-of-mbl2-contribute-to-tuberculosis-ris-peer-reviewed-article-IDRMBL2rs1800450rs1800451rs5030737tuberculosis |
| spellingShingle | Wu YJ Yang X Chen TD Zhang ZX You YZ Fan ZD Genetic polymorphisms of exon 1 of MBL2 contribute to tuberculosis risk especially in Asian populations: an updated meta-analysis of 26 studies Infection and Drug Resistance MBL2 rs1800450 rs1800451 rs5030737 tuberculosis |
| title | Genetic polymorphisms of exon 1 of MBL2 contribute to tuberculosis risk especially in Asian populations: an updated meta-analysis of 26 studies |
| title_full | Genetic polymorphisms of exon 1 of MBL2 contribute to tuberculosis risk especially in Asian populations: an updated meta-analysis of 26 studies |
| title_fullStr | Genetic polymorphisms of exon 1 of MBL2 contribute to tuberculosis risk especially in Asian populations: an updated meta-analysis of 26 studies |
| title_full_unstemmed | Genetic polymorphisms of exon 1 of MBL2 contribute to tuberculosis risk especially in Asian populations: an updated meta-analysis of 26 studies |
| title_short | Genetic polymorphisms of exon 1 of MBL2 contribute to tuberculosis risk especially in Asian populations: an updated meta-analysis of 26 studies |
| title_sort | genetic polymorphisms of exon 1 of mbl2 contribute to tuberculosis risk especially in asian populations an updated meta analysis of 26 studies |
| topic | MBL2 rs1800450 rs1800451 rs5030737 tuberculosis |
| url | https://www.dovepress.com/genetic-polymorphisms-of-exon-1-of-mbl2-contribute-to-tuberculosis-ris-peer-reviewed-article-IDR |
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