Targeted Alpha Therapy: Progress in Radionuclide Production, Radiochemistry, and Applications
This review outlines the accomplishments and potential developments of targeted alpha (α) particle therapy (TAT). It discusses the therapeutic advantages of the short and highly ionizing path of α-particle emissions; the ability of TAT to complement and provide superior efficacy over existing forms...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-12-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/13/1/49 |
| _version_ | 1827698764440141824 |
|---|---|
| author | Bryce J. B. Nelson Jan D. Andersson Frank Wuest |
| author_facet | Bryce J. B. Nelson Jan D. Andersson Frank Wuest |
| author_sort | Bryce J. B. Nelson |
| collection | DOAJ |
| description | This review outlines the accomplishments and potential developments of targeted alpha (α) particle therapy (TAT). It discusses the therapeutic advantages of the short and highly ionizing path of α-particle emissions; the ability of TAT to complement and provide superior efficacy over existing forms of radiotherapy; the physical decay properties and radiochemistry of common α-emitters, including <sup>225</sup>Ac, <sup>213</sup>Bi, <sup>224</sup>Ra, <sup>212</sup>Pb, <sup>227</sup>Th, <sup>223</sup>Ra, <sup>211</sup>At, and <sup>149</sup>Tb; the production techniques and proper handling of α-emitters in a radiopharmacy; recent preclinical developments; ongoing and completed clinical trials; and an outlook on the future of TAT. |
| first_indexed | 2024-03-10T13:35:48Z |
| format | Article |
| id | doaj.art-6308c207e5d24817b8d074ce2383576b |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T13:35:48Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-6308c207e5d24817b8d074ce2383576b2023-11-21T07:31:10ZengMDPI AGPharmaceutics1999-49232020-12-011314910.3390/pharmaceutics13010049Targeted Alpha Therapy: Progress in Radionuclide Production, Radiochemistry, and ApplicationsBryce J. B. Nelson0Jan D. Andersson1Frank Wuest2Department of Oncology, University of Alberta, 11560 University Ave, Edmonton, AB T6G 1Z2, CanadaDepartment of Oncology, University of Alberta, 11560 University Ave, Edmonton, AB T6G 1Z2, CanadaDepartment of Oncology, University of Alberta, 11560 University Ave, Edmonton, AB T6G 1Z2, CanadaThis review outlines the accomplishments and potential developments of targeted alpha (α) particle therapy (TAT). It discusses the therapeutic advantages of the short and highly ionizing path of α-particle emissions; the ability of TAT to complement and provide superior efficacy over existing forms of radiotherapy; the physical decay properties and radiochemistry of common α-emitters, including <sup>225</sup>Ac, <sup>213</sup>Bi, <sup>224</sup>Ra, <sup>212</sup>Pb, <sup>227</sup>Th, <sup>223</sup>Ra, <sup>211</sup>At, and <sup>149</sup>Tb; the production techniques and proper handling of α-emitters in a radiopharmacy; recent preclinical developments; ongoing and completed clinical trials; and an outlook on the future of TAT.https://www.mdpi.com/1999-4923/13/1/49targeted alpha therapyalpha particle therapytargeted radionuclide therapytheranosticsactinium-225bismuth-213 |
| spellingShingle | Bryce J. B. Nelson Jan D. Andersson Frank Wuest Targeted Alpha Therapy: Progress in Radionuclide Production, Radiochemistry, and Applications Pharmaceutics targeted alpha therapy alpha particle therapy targeted radionuclide therapy theranostics actinium-225 bismuth-213 |
| title | Targeted Alpha Therapy: Progress in Radionuclide Production, Radiochemistry, and Applications |
| title_full | Targeted Alpha Therapy: Progress in Radionuclide Production, Radiochemistry, and Applications |
| title_fullStr | Targeted Alpha Therapy: Progress in Radionuclide Production, Radiochemistry, and Applications |
| title_full_unstemmed | Targeted Alpha Therapy: Progress in Radionuclide Production, Radiochemistry, and Applications |
| title_short | Targeted Alpha Therapy: Progress in Radionuclide Production, Radiochemistry, and Applications |
| title_sort | targeted alpha therapy progress in radionuclide production radiochemistry and applications |
| topic | targeted alpha therapy alpha particle therapy targeted radionuclide therapy theranostics actinium-225 bismuth-213 |
| url | https://www.mdpi.com/1999-4923/13/1/49 |
| work_keys_str_mv | AT brycejbnelson targetedalphatherapyprogressinradionuclideproductionradiochemistryandapplications AT jandandersson targetedalphatherapyprogressinradionuclideproductionradiochemistryandapplications AT frankwuest targetedalphatherapyprogressinradionuclideproductionradiochemistryandapplications |