In-vitro hemolytic activity and free radical scavenging by sol-gel synthesized Fe3O4 stabilized ZrO2 nanoparticles
Zirconia ceramics have attained much consideration owing to the amazing mechanical strength and white color. These properties provide an opportunity for the use in biomedical applications. In the present study, an application oriented sol-gel route was adapted for synthesis of zirconia nanoparticles...
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Elsevier
2020-11-01
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| Series: | Arabian Journal of Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535220303178 |
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| author | M. Imran Saira Riaz S. Mazhar H. Shah Tanzeela Batool Hera N. Khan Anjum N. Sabri Shahzad Naseem |
| author_facet | M. Imran Saira Riaz S. Mazhar H. Shah Tanzeela Batool Hera N. Khan Anjum N. Sabri Shahzad Naseem |
| author_sort | M. Imran |
| collection | DOAJ |
| description | Zirconia ceramics have attained much consideration owing to the amazing mechanical strength and white color. These properties provide an opportunity for the use in biomedical applications. In the present study, an application oriented sol-gel route was adapted for synthesis of zirconia nanoparticles. ZrOCl2·8H2O was used as a precursor, iron oxide (Fe3O4) nanoparticles (pH 2 & pH 9) as a stabilizer and de-ionized water was used as a solvent. Sol-gel synthesized iron oxide stabilized zirconia nanoparticles were prepared by varying concentrations of iron oxide nanoparticles in the range of 2–10 wt%. X-ray diffraction results showed mixed phases at all wt% with acidic pH value, while pure tetragonal phase of zirconia was observed for stabilization with 6 wt% basic iron oxide. Maximum value of dielectric constant (~80 at log f = 4) and minimum value of tangent loss (~0.66 at log f = 4) were observed for zirconia stabilized with basic 6 wt% iron oxide. Maximum value of hardness (1410 ± 10 HV) along with high fracture toughness were observed with optimized stabilization. Very weak hemolytic activity and maximum scavenging (~76) antioxidant activity was observed under optimized conditions. Thus, it can be suggested that optimized nanoparticles, i.e. tetragonal zirconia stabilized with 6 wt% of basic Fe3O4, can be further useful for therapeutical and pharmaceutical applications. |
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| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-12-14T23:12:42Z |
| publishDate | 2020-11-01 |
| publisher | Elsevier |
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| series | Arabian Journal of Chemistry |
| spelling | doaj.art-630d50630fb0417bab9c56d3298545e02022-12-21T22:44:09ZengElsevierArabian Journal of Chemistry1878-53522020-11-01131175987608In-vitro hemolytic activity and free radical scavenging by sol-gel synthesized Fe3O4 stabilized ZrO2 nanoparticlesM. Imran0Saira Riaz1S. Mazhar H. Shah2Tanzeela Batool3Hera N. Khan4Anjum N. Sabri5Shahzad Naseem6Centre of Excellence in Solid State Physics, University of the Punjab, Lahore, PakistanCentre of Excellence in Solid State Physics, University of the Punjab, Lahore, Pakistan; Corresponding author.Govt. Islamia Degree College for Boys, Lahore Cantt, PakistanCentre of Excellence in Solid State Physics, University of the Punjab, Lahore, PakistanDepartment of Microbiology and Molecular Genetics, University of the Punjab, Lahore, PakistanDepartment of Microbiology and Molecular Genetics, University of the Punjab, Lahore, PakistanCentre of Excellence in Solid State Physics, University of the Punjab, Lahore, PakistanZirconia ceramics have attained much consideration owing to the amazing mechanical strength and white color. These properties provide an opportunity for the use in biomedical applications. In the present study, an application oriented sol-gel route was adapted for synthesis of zirconia nanoparticles. ZrOCl2·8H2O was used as a precursor, iron oxide (Fe3O4) nanoparticles (pH 2 & pH 9) as a stabilizer and de-ionized water was used as a solvent. Sol-gel synthesized iron oxide stabilized zirconia nanoparticles were prepared by varying concentrations of iron oxide nanoparticles in the range of 2–10 wt%. X-ray diffraction results showed mixed phases at all wt% with acidic pH value, while pure tetragonal phase of zirconia was observed for stabilization with 6 wt% basic iron oxide. Maximum value of dielectric constant (~80 at log f = 4) and minimum value of tangent loss (~0.66 at log f = 4) were observed for zirconia stabilized with basic 6 wt% iron oxide. Maximum value of hardness (1410 ± 10 HV) along with high fracture toughness were observed with optimized stabilization. Very weak hemolytic activity and maximum scavenging (~76) antioxidant activity was observed under optimized conditions. Thus, it can be suggested that optimized nanoparticles, i.e. tetragonal zirconia stabilized with 6 wt% of basic Fe3O4, can be further useful for therapeutical and pharmaceutical applications.http://www.sciencedirect.com/science/article/pii/S1878535220303178HemolyticAnti-oxidantSol-GelFe3O4ZrO2Nanoparticles |
| spellingShingle | M. Imran Saira Riaz S. Mazhar H. Shah Tanzeela Batool Hera N. Khan Anjum N. Sabri Shahzad Naseem In-vitro hemolytic activity and free radical scavenging by sol-gel synthesized Fe3O4 stabilized ZrO2 nanoparticles Arabian Journal of Chemistry Hemolytic Anti-oxidant Sol-Gel Fe3O4 ZrO2 Nanoparticles |
| title | In-vitro hemolytic activity and free radical scavenging by sol-gel synthesized Fe3O4 stabilized ZrO2 nanoparticles |
| title_full | In-vitro hemolytic activity and free radical scavenging by sol-gel synthesized Fe3O4 stabilized ZrO2 nanoparticles |
| title_fullStr | In-vitro hemolytic activity and free radical scavenging by sol-gel synthesized Fe3O4 stabilized ZrO2 nanoparticles |
| title_full_unstemmed | In-vitro hemolytic activity and free radical scavenging by sol-gel synthesized Fe3O4 stabilized ZrO2 nanoparticles |
| title_short | In-vitro hemolytic activity and free radical scavenging by sol-gel synthesized Fe3O4 stabilized ZrO2 nanoparticles |
| title_sort | in vitro hemolytic activity and free radical scavenging by sol gel synthesized fe3o4 stabilized zro2 nanoparticles |
| topic | Hemolytic Anti-oxidant Sol-Gel Fe3O4 ZrO2 Nanoparticles |
| url | http://www.sciencedirect.com/science/article/pii/S1878535220303178 |
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