Ovarian Microbiota, Ovarian Cancer and the Underestimated Role of HPV
In recent years, many studies have highlighted the possible close correlation between human diseases and definite patterns of microbial organisms colonizing various organs. Even at sites traditionally considered sterile, such as the upper female reproductive tract (FRT), it is now well-recognized as...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/24/16019 |
| _version_ | 1797457199574810624 |
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| author | Massimiliano Cazzaniga Marco Cardinali Francesco Di Pierro Alexander Bertuccioli |
| author_facet | Massimiliano Cazzaniga Marco Cardinali Francesco Di Pierro Alexander Bertuccioli |
| author_sort | Massimiliano Cazzaniga |
| collection | DOAJ |
| description | In recent years, many studies have highlighted the possible close correlation between human diseases and definite patterns of microbial organisms colonizing various organs. Even at sites traditionally considered sterile, such as the upper female reproductive tract (FRT), it is now well-recognized as hosting a low biomass of different bacterial phyla. Additionally, the data from recent studies highlight a possible link between lower and upper FRT dysbiosis with a potential predisposition to cervical and ovarian cancer. Acinetobacter, chlamydia, increased mycoplasma, and lactobacillary scarcity in the upper FRT have all been linked to a predisposition to ovarian cancer. Additionally, a high-diversity vaginal community state type (CST) is linked to the presence and persistence of high-risk human papillomavirus (HPV), resulting in decreased cellular p53 activity and a reduction in the immune activity of T lymphocytes, resulting in cervical and ovarian cancer predisposition. While these findings are still far from being clarified in all aspects, in patients with multiple risk factors for ovarian cancer, a <i>Lactobacillus crispatus</i> treatment with a product with a proven ability to restore a favorable CST should be considered as an add-on therapy. |
| first_indexed | 2024-03-09T16:18:46Z |
| format | Article |
| id | doaj.art-630e2f7b958e47c2a4955e09092b3503 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T16:18:46Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-630e2f7b958e47c2a4955e09092b35032023-11-24T15:31:31ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-0123241601910.3390/ijms232416019Ovarian Microbiota, Ovarian Cancer and the Underestimated Role of HPVMassimiliano Cazzaniga0Marco Cardinali1Francesco Di Pierro2Alexander Bertuccioli3Scientific & Research Department, Velleja Research, 20125 Milano, ItalyDepartment of Internal Medicine, Infermi Hospital, AUSL Romagna, 47921 Rimini, ItalyScientific & Research Department, Velleja Research, 20125 Milano, ItalyDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, 61122 Urbino, ItalyIn recent years, many studies have highlighted the possible close correlation between human diseases and definite patterns of microbial organisms colonizing various organs. Even at sites traditionally considered sterile, such as the upper female reproductive tract (FRT), it is now well-recognized as hosting a low biomass of different bacterial phyla. Additionally, the data from recent studies highlight a possible link between lower and upper FRT dysbiosis with a potential predisposition to cervical and ovarian cancer. Acinetobacter, chlamydia, increased mycoplasma, and lactobacillary scarcity in the upper FRT have all been linked to a predisposition to ovarian cancer. Additionally, a high-diversity vaginal community state type (CST) is linked to the presence and persistence of high-risk human papillomavirus (HPV), resulting in decreased cellular p53 activity and a reduction in the immune activity of T lymphocytes, resulting in cervical and ovarian cancer predisposition. While these findings are still far from being clarified in all aspects, in patients with multiple risk factors for ovarian cancer, a <i>Lactobacillus crispatus</i> treatment with a product with a proven ability to restore a favorable CST should be considered as an add-on therapy.https://www.mdpi.com/1422-0067/23/24/16019cancermicrobiotaHPVlactobacilluslentinula edodensAHCC |
| spellingShingle | Massimiliano Cazzaniga Marco Cardinali Francesco Di Pierro Alexander Bertuccioli Ovarian Microbiota, Ovarian Cancer and the Underestimated Role of HPV International Journal of Molecular Sciences cancer microbiota HPV lactobacillus lentinula edodens AHCC |
| title | Ovarian Microbiota, Ovarian Cancer and the Underestimated Role of HPV |
| title_full | Ovarian Microbiota, Ovarian Cancer and the Underestimated Role of HPV |
| title_fullStr | Ovarian Microbiota, Ovarian Cancer and the Underestimated Role of HPV |
| title_full_unstemmed | Ovarian Microbiota, Ovarian Cancer and the Underestimated Role of HPV |
| title_short | Ovarian Microbiota, Ovarian Cancer and the Underestimated Role of HPV |
| title_sort | ovarian microbiota ovarian cancer and the underestimated role of hpv |
| topic | cancer microbiota HPV lactobacillus lentinula edodens AHCC |
| url | https://www.mdpi.com/1422-0067/23/24/16019 |
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