Tibolone Pre-Treatment Ameliorates the Dysregulation of Protein Translation and Transport Generated by Palmitic Acid-Induced Lipotoxicity in Human Astrocytes: A Label-Free MS-Based Proteomics and Network Analysis

Tibolone Pre-Treatment Ameliorates the Dysregulation of Protein Translation and Transport Generated by Palmitic Acid-Induced Lipotoxicity in Human Astrocytes: A Label-Free MS-Based Proteomics and Network Analysis

Excessive accumulation and release of fatty acids (FAs) in adipose and non-adipose tissue are characteristic of obesity and are associated with the leading causes of death worldwide. Chronic exposure to high concentrations of FAs such as palmitic acid (pal) is a risk factor for developing different...

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Bibliographic Details
Main Authors: Diego Julián Vesga-Jiménez, Cynthia A. Martín-Jiménez, Adriana Grismaldo Rodríguez, Andrés Felipe Aristizábal-Pachón, Andrés Pinzón, George E. Barreto, David Ramírez, Janneth González
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:International Journal of Molecular Sciences
Subjects:
mass spectrometry
human astrocytes
tibolone
palmitic acid
obesity
neuroprotection
Online Access:https://www.mdpi.com/1422-0067/23/12/6454

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https://www.mdpi.com/1422-0067/23/12/6454

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