A Differential Profile of Biomarkers between Patients with Atrial Fibrillation and Healthy Controls
Atrial fibrillation (AF) is explained by anatomical and electrophysiological changes in the atria determined by high pressure, dilatation, infiltration and inflammation in the myocardium. There are some biomarkers implicated in these processes, namely, NT-proBNP, high sensitivity troponin (Hs-Tn), u...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/9/1406 |
| _version_ | 1797486157802504192 |
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| author | Ana Merino-Merino Ruth Saez-Maleta Ricardo Salgado-Aranda Daniel AlKassam-Martinez Virginia Pascual-Tejerina Javier Martin-Gonzalez Javier Garcia-Fernandez Jose-Angel Perez-Rivera |
| author_facet | Ana Merino-Merino Ruth Saez-Maleta Ricardo Salgado-Aranda Daniel AlKassam-Martinez Virginia Pascual-Tejerina Javier Martin-Gonzalez Javier Garcia-Fernandez Jose-Angel Perez-Rivera |
| author_sort | Ana Merino-Merino |
| collection | DOAJ |
| description | Atrial fibrillation (AF) is explained by anatomical and electrophysiological changes in the atria determined by high pressure, dilatation, infiltration and inflammation in the myocardium. There are some biomarkers implicated in these processes, namely, NT-proBNP, high sensitivity troponin (Hs-Tn), urate, galectin-3, ST2, C reactive protein and fibrinogen. The aim of this study was to assess differences in these biomarkers between patients with AF and healthy controls. We designed a cross-sectional study consecutively including all patients undergoing electrical cardioversion in our hospital for persistent AF and matched healthy controls. We included 115 patients with persistent non-valvular AF and 33 healthy subjects. The biomarkers NT-proBNP, ST2 and Hs-Tn T were significantly related to the presence of AF (1054 ± 833.30 vs. 58.31 ± 59.40, <i>p</i> < 0.001; 35.43 ± 15.89 vs. 27.43 ± 10.95, <i>p</i> < 0.001 and 10.25 ± 6.11 vs. 8.42 ± 6.85, <i>p</i> < 0.001, respectively). NT-proBNP was the best biomarker differentiating AF patients (area under the curve 0.995). The best NT-proBNP cut-off point to differentiate AF was 102 pg/mL; for Hs-Tn T it was 11.5 ng/L and for ST2 it was 37.7 ng/mL. It is possible that these biomarkers intervene at the onset of AF and have no role in AF maintenance. |
| first_indexed | 2024-03-09T23:29:12Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T23:29:12Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-63106e789a0541db9bb256d86484661a2023-11-23T17:12:36ZengMDPI AGJournal of Personalized Medicine2075-44262022-08-01129140610.3390/jpm12091406A Differential Profile of Biomarkers between Patients with Atrial Fibrillation and Healthy ControlsAna Merino-Merino0Ruth Saez-Maleta1Ricardo Salgado-Aranda2Daniel AlKassam-Martinez3Virginia Pascual-Tejerina4Javier Martin-Gonzalez5Javier Garcia-Fernandez6Jose-Angel Perez-Rivera7Cardiology Department, Hospital Universitario de Burgos, 09006 Burgos, SpainClinical Analyses Department, Hospital Universitario de Burgos, 09006 Burgos, SpainCardiology Department, Hospital Universitario de Burgos, 09006 Burgos, SpainClinical Analyses Department, Hospital Universitario de Burgos, 09006 Burgos, SpainCardiology Department, Hospital Universitario de Burgos, 09006 Burgos, SpainCardiology Department, Hospital Universitario de Burgos, 09006 Burgos, SpainCardiology Department, Hospital Universitario de Burgos, 09006 Burgos, SpainCardiology Department, Hospital Universitario de Burgos, 09006 Burgos, SpainAtrial fibrillation (AF) is explained by anatomical and electrophysiological changes in the atria determined by high pressure, dilatation, infiltration and inflammation in the myocardium. There are some biomarkers implicated in these processes, namely, NT-proBNP, high sensitivity troponin (Hs-Tn), urate, galectin-3, ST2, C reactive protein and fibrinogen. The aim of this study was to assess differences in these biomarkers between patients with AF and healthy controls. We designed a cross-sectional study consecutively including all patients undergoing electrical cardioversion in our hospital for persistent AF and matched healthy controls. We included 115 patients with persistent non-valvular AF and 33 healthy subjects. The biomarkers NT-proBNP, ST2 and Hs-Tn T were significantly related to the presence of AF (1054 ± 833.30 vs. 58.31 ± 59.40, <i>p</i> < 0.001; 35.43 ± 15.89 vs. 27.43 ± 10.95, <i>p</i> < 0.001 and 10.25 ± 6.11 vs. 8.42 ± 6.85, <i>p</i> < 0.001, respectively). NT-proBNP was the best biomarker differentiating AF patients (area under the curve 0.995). The best NT-proBNP cut-off point to differentiate AF was 102 pg/mL; for Hs-Tn T it was 11.5 ng/L and for ST2 it was 37.7 ng/mL. It is possible that these biomarkers intervene at the onset of AF and have no role in AF maintenance.https://www.mdpi.com/2075-4426/12/9/1406atrial fibrillationbiomarkersNT-proBNP |
| spellingShingle | Ana Merino-Merino Ruth Saez-Maleta Ricardo Salgado-Aranda Daniel AlKassam-Martinez Virginia Pascual-Tejerina Javier Martin-Gonzalez Javier Garcia-Fernandez Jose-Angel Perez-Rivera A Differential Profile of Biomarkers between Patients with Atrial Fibrillation and Healthy Controls Journal of Personalized Medicine atrial fibrillation biomarkers NT-proBNP |
| title | A Differential Profile of Biomarkers between Patients with Atrial Fibrillation and Healthy Controls |
| title_full | A Differential Profile of Biomarkers between Patients with Atrial Fibrillation and Healthy Controls |
| title_fullStr | A Differential Profile of Biomarkers between Patients with Atrial Fibrillation and Healthy Controls |
| title_full_unstemmed | A Differential Profile of Biomarkers between Patients with Atrial Fibrillation and Healthy Controls |
| title_short | A Differential Profile of Biomarkers between Patients with Atrial Fibrillation and Healthy Controls |
| title_sort | differential profile of biomarkers between patients with atrial fibrillation and healthy controls |
| topic | atrial fibrillation biomarkers NT-proBNP |
| url | https://www.mdpi.com/2075-4426/12/9/1406 |
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