Clinical characteristics of paraneoplastic syndromes in patients with head and neck cancer
Abstract Background To summarize the clinical manifestations, diagnosis, and prognosis of head and neck cancer (HNC) patients with paraneoplastic syndromes (PNS). Methods The clinical data of 1958 patients with HNC admitted to our hospital from January 1996 to December 2020 were retrospectively anal...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-08-01
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| Series: | Laryngoscope Investigative Otolaryngology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/lio2.849 |
| _version_ | 1818516693479063552 |
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| author | Wenwen Diao Ya Liang Liming Gao Yingying Zhu Xiaoli Zhu Shuting Yu Xin Xia Xingming Chen |
| author_facet | Wenwen Diao Ya Liang Liming Gao Yingying Zhu Xiaoli Zhu Shuting Yu Xin Xia Xingming Chen |
| author_sort | Wenwen Diao |
| collection | DOAJ |
| description | Abstract Background To summarize the clinical manifestations, diagnosis, and prognosis of head and neck cancer (HNC) patients with paraneoplastic syndromes (PNS). Methods The clinical data of 1958 patients with HNC admitted to our hospital from January 1996 to December 2020 were retrospectively analyzed. Demographic and cancer‐related characteristics were extracted. Kaplan–Meier survival curves were compared by log‐rank test. Cox regression was performed to evaluate prognostic factors and hazard ratio. Results Totally 40 HNC patients with PNS were included in the final analysis, including 36 men and four women with a mean age of 60.4 years (range 40–82). PNS was dermatologic or cutaneous in 23 (57.50%) patients, endocrine in 10 (25.00%), neurologic in five (12.50%), and osteoarticular or rheumatologic in two (5.00%). Twenty‐five (62.50%) patients had Stage III/IV cancer. PNS regressed after antitumor therapy in 28 (70.00%) patients. Recurrence of PNS was observed in nine of 12 (75.00%) patients with cancer recurrence or metastasis. The 5‐year overall survival (OS) and disease‐free survival (DFS) rates of patients with PNS were 51.52% and 44.44%, respectively. The DFS (p = .001) and OS (p = .003) of patients presented with PNS prior to HNC diagnosis were significantly longer than those of patients with synchronous or metachronous PNS. PNS diagnosed before HNC (adjusted hazard ratio [aHR]: 0.31, 95% confidence interval [CI]: 0.11–0.85, p = .02), Stage IV disease (aHR: 3.27, 95% CI: 1.18–9.05, p = .02), and smoking history (aHR: 3.69, 95% CI: 1.04–13.05, p = .04) were significantly associated with OS and DFS. Conclusions Early recognition of PNS could provide clues about underlying tumor condition and result in early diagnosis. Prompt detection of cancer‐associated syndromes could lead to a more favorable prognosis for these patients. |
| first_indexed | 2024-12-11T00:45:38Z |
| format | Article |
| id | doaj.art-63125fd9d70c43aba33740ce52108c02 |
| institution | Directory Open Access Journal |
| issn | 2378-8038 |
| language | English |
| last_indexed | 2024-12-11T00:45:38Z |
| publishDate | 2022-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Laryngoscope Investigative Otolaryngology |
| spelling | doaj.art-63125fd9d70c43aba33740ce52108c022022-12-22T01:26:47ZengWileyLaryngoscope Investigative Otolaryngology2378-80382022-08-01741002101010.1002/lio2.849Clinical characteristics of paraneoplastic syndromes in patients with head and neck cancerWenwen Diao0Ya Liang1Liming Gao2Yingying Zhu3Xiaoli Zhu4Shuting Yu5Xin Xia6Xingming Chen7Department of Otolaryngology–Head and Neck Surgery Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences Beijing ChinaDepartment of Otorhinolaryngology Affiliated Hospital of Guizhou Medical University Guiyang ChinaDepartment of Otolaryngology–Head and Neck Surgery Beijing Tiantan Hospital, Capital Medical University Beijing ChinaDepartment of Otolaryngology–Head and Neck Surgery Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences Beijing ChinaDepartment of Otolaryngology–Head and Neck Surgery Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences Beijing ChinaDepartment of Otolaryngology–Head and Neck Surgery Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences Beijing ChinaDepartment of Otolaryngology–Head and Neck Surgery Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences Beijing ChinaDepartment of Otolaryngology–Head and Neck Surgery Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences Beijing ChinaAbstract Background To summarize the clinical manifestations, diagnosis, and prognosis of head and neck cancer (HNC) patients with paraneoplastic syndromes (PNS). Methods The clinical data of 1958 patients with HNC admitted to our hospital from January 1996 to December 2020 were retrospectively analyzed. Demographic and cancer‐related characteristics were extracted. Kaplan–Meier survival curves were compared by log‐rank test. Cox regression was performed to evaluate prognostic factors and hazard ratio. Results Totally 40 HNC patients with PNS were included in the final analysis, including 36 men and four women with a mean age of 60.4 years (range 40–82). PNS was dermatologic or cutaneous in 23 (57.50%) patients, endocrine in 10 (25.00%), neurologic in five (12.50%), and osteoarticular or rheumatologic in two (5.00%). Twenty‐five (62.50%) patients had Stage III/IV cancer. PNS regressed after antitumor therapy in 28 (70.00%) patients. Recurrence of PNS was observed in nine of 12 (75.00%) patients with cancer recurrence or metastasis. The 5‐year overall survival (OS) and disease‐free survival (DFS) rates of patients with PNS were 51.52% and 44.44%, respectively. The DFS (p = .001) and OS (p = .003) of patients presented with PNS prior to HNC diagnosis were significantly longer than those of patients with synchronous or metachronous PNS. PNS diagnosed before HNC (adjusted hazard ratio [aHR]: 0.31, 95% confidence interval [CI]: 0.11–0.85, p = .02), Stage IV disease (aHR: 3.27, 95% CI: 1.18–9.05, p = .02), and smoking history (aHR: 3.69, 95% CI: 1.04–13.05, p = .04) were significantly associated with OS and DFS. Conclusions Early recognition of PNS could provide clues about underlying tumor condition and result in early diagnosis. Prompt detection of cancer‐associated syndromes could lead to a more favorable prognosis for these patients.https://doi.org/10.1002/lio2.849head and neck cancerparaneoplastic syndromeprognosistreatment |
| spellingShingle | Wenwen Diao Ya Liang Liming Gao Yingying Zhu Xiaoli Zhu Shuting Yu Xin Xia Xingming Chen Clinical characteristics of paraneoplastic syndromes in patients with head and neck cancer Laryngoscope Investigative Otolaryngology head and neck cancer paraneoplastic syndrome prognosis treatment |
| title | Clinical characteristics of paraneoplastic syndromes in patients with head and neck cancer |
| title_full | Clinical characteristics of paraneoplastic syndromes in patients with head and neck cancer |
| title_fullStr | Clinical characteristics of paraneoplastic syndromes in patients with head and neck cancer |
| title_full_unstemmed | Clinical characteristics of paraneoplastic syndromes in patients with head and neck cancer |
| title_short | Clinical characteristics of paraneoplastic syndromes in patients with head and neck cancer |
| title_sort | clinical characteristics of paraneoplastic syndromes in patients with head and neck cancer |
| topic | head and neck cancer paraneoplastic syndrome prognosis treatment |
| url | https://doi.org/10.1002/lio2.849 |
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