An autophagy-related long non-coding RNA signature in tongue squamous cell carcinoma
Abstract Background Tongue squamous cell carcinoma (TSCC) is the most common oral cancer with a poor prognosis. At present, there is not any systematic study on autophagy-related long non-coding RNA (lncRNA) to predict the survival of patients with TSCC. Material and methods In this research, the co...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | BMC Oral Health |
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| Online Access: | https://doi.org/10.1186/s12903-023-02806-5 |
| _version_ | 1797863328543932416 |
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| author | Yinting Ren Junlong Da Junyu Ren Ye Song Jingying Han |
| author_facet | Yinting Ren Junlong Da Junyu Ren Ye Song Jingying Han |
| author_sort | Yinting Ren |
| collection | DOAJ |
| description | Abstract Background Tongue squamous cell carcinoma (TSCC) is the most common oral cancer with a poor prognosis. At present, there is not any systematic study on autophagy-related long non-coding RNA (lncRNA) to predict the survival of patients with TSCC. Material and methods In this research, the cohort of TSCC patients were obtained from The Cancer Genome Atlas (TCGA) database. Univariate and multivariate Cox regression analysis showed that ten lncRNAs related to autophagy AC010326.3, AL160006.1, AL122010.1, AC139530.1, AC092747.4, AL139287.1, MIR503HG, AC009318.2, LINC01711, and LINC02560 are significantly correlated with prognosis. Based on these lncRNAs, a prognostic signature was established. This signature has an AUC value of 0.782, which accurately distinguishes patients of TSCC into high-risk and low-risk groups in different clinical hierarchical information (such as gender, age, etc.). Results The clinical nomogram with autophagy-related lncRNA prognostic characteristics has a concordance index of 0.81, and accurately predicts the survival time at 1-year and 3-year of TSCC patients. Related functional enrichment results indicate that the pathways of the high-risk group are enriched on cancer and autophagy. Conclusions The autophagy-related lncRNA prognostic signature established in this study could accurately predict the prognosis of TSCC patients and may be a molecular biomarker and therapeutic target. |
| first_indexed | 2024-04-09T22:34:57Z |
| format | Article |
| id | doaj.art-6312a685115c4856b07fd38f638caf6a |
| institution | Directory Open Access Journal |
| issn | 1472-6831 |
| language | English |
| last_indexed | 2024-04-09T22:34:57Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj.art-6312a685115c4856b07fd38f638caf6a2023-03-22T12:33:52ZengBMCBMC Oral Health1472-68312023-02-0123111310.1186/s12903-023-02806-5An autophagy-related long non-coding RNA signature in tongue squamous cell carcinomaYinting Ren0Junlong Da1Junyu Ren2Ye Song3Jingying Han4Department of Orthodontics, The Second Affiliated Hospital of Harbin Medical UniversityInstitute of Hard Tissue Development and Regeneration, The Second Affiliated Hospital of Harbin Medical UniversityOral Implant Center, The Second Affiliated Hospital of Harbin Medical UniversityDepartment of Orthodontics, The Second Affiliated Hospital of Harbin Medical UniversityDepartment of Orthodontics, The Second Affiliated Hospital of Harbin Medical UniversityAbstract Background Tongue squamous cell carcinoma (TSCC) is the most common oral cancer with a poor prognosis. At present, there is not any systematic study on autophagy-related long non-coding RNA (lncRNA) to predict the survival of patients with TSCC. Material and methods In this research, the cohort of TSCC patients were obtained from The Cancer Genome Atlas (TCGA) database. Univariate and multivariate Cox regression analysis showed that ten lncRNAs related to autophagy AC010326.3, AL160006.1, AL122010.1, AC139530.1, AC092747.4, AL139287.1, MIR503HG, AC009318.2, LINC01711, and LINC02560 are significantly correlated with prognosis. Based on these lncRNAs, a prognostic signature was established. This signature has an AUC value of 0.782, which accurately distinguishes patients of TSCC into high-risk and low-risk groups in different clinical hierarchical information (such as gender, age, etc.). Results The clinical nomogram with autophagy-related lncRNA prognostic characteristics has a concordance index of 0.81, and accurately predicts the survival time at 1-year and 3-year of TSCC patients. Related functional enrichment results indicate that the pathways of the high-risk group are enriched on cancer and autophagy. Conclusions The autophagy-related lncRNA prognostic signature established in this study could accurately predict the prognosis of TSCC patients and may be a molecular biomarker and therapeutic target.https://doi.org/10.1186/s12903-023-02806-5AutophagyLong non-coding RNATongue squamous cell carcinomaTCGAPrognostic signature |
| spellingShingle | Yinting Ren Junlong Da Junyu Ren Ye Song Jingying Han An autophagy-related long non-coding RNA signature in tongue squamous cell carcinoma BMC Oral Health Autophagy Long non-coding RNA Tongue squamous cell carcinoma TCGA Prognostic signature |
| title | An autophagy-related long non-coding RNA signature in tongue squamous cell carcinoma |
| title_full | An autophagy-related long non-coding RNA signature in tongue squamous cell carcinoma |
| title_fullStr | An autophagy-related long non-coding RNA signature in tongue squamous cell carcinoma |
| title_full_unstemmed | An autophagy-related long non-coding RNA signature in tongue squamous cell carcinoma |
| title_short | An autophagy-related long non-coding RNA signature in tongue squamous cell carcinoma |
| title_sort | autophagy related long non coding rna signature in tongue squamous cell carcinoma |
| topic | Autophagy Long non-coding RNA Tongue squamous cell carcinoma TCGA Prognostic signature |
| url | https://doi.org/10.1186/s12903-023-02806-5 |
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