Efficacy and safety of Argatroban in patients with acute ischemic stroke: a systematic review and meta-analysis
ObjectiveArgatroban is a highly promising drug for the treatment of acute ischemic stroke (AIS), but there is currently insufficient strong evidence regarding the efficacy and safety of using Argatroban in the treatment of AIS. Therefore, we conducted a systematic review and meta-analysis to evaluat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2024.1364895/full |
| _version_ | 1797303313686855680 |
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| author | YiRan Cheng ChangNing Liu ShanShan Li Miao Miao Meng He Li |
| author_facet | YiRan Cheng ChangNing Liu ShanShan Li Miao Miao Meng He Li |
| author_sort | YiRan Cheng |
| collection | DOAJ |
| description | ObjectiveArgatroban is a highly promising drug for the treatment of acute ischemic stroke (AIS), but there is currently insufficient strong evidence regarding the efficacy and safety of using Argatroban in the treatment of AIS. Therefore, we conducted a systematic review and meta-analysis to evaluate the effectiveness and safety of Argatroban in the treatment of AIS.MethodsArticles on PubMed, Embase and the Cochrane Library databases were searched from these websites’ inceptions to 2th February 2023. Randomized controlled trials and observational studies on Argatroban therapy for acute ischemic stroke were included. Meta-analyses were conducted using a random-effects model.ResultsFourteen studies involving 10,315 patients were included in the meta-analysis. The results showed a significant reduction in the rate of early neurological deterioration (END) in the Argatroban group compared with the control group (OR = 0.47, 95% CI: 0.31–0.73, I2 = 15.17%). The rates of adverse events were no significant difference between the two groups (ICH: OR = 1.02, 95% CI: 0.68–1.51, I2 = 0.00%; major extracranial bleeding: OR = 1.22, 95% CI: 1.01–1.48, I2 = 0.00%; mortality: OR = 1.16, 95% CI: 0.84–1.59, I2 = 0.00%). However, the rates of mRS score of 0–1 (OR = 1.38, 95% CI: 0.71–2.67, I2 = 77.56%) and mRS score of 0–2 (OR = 1.18, 95% CI: 0.98–1.42, I2 = 0.00%) during the 90 days did not significantly improved in the Argatroban group. Subgroup analyses showed that the rate of END (OR = 0.41, 95% CI: 0.26–0.65, I2 = 2.77%) and mRS score of 0–2 (OR = 1.38, 95% CI: 1.06–1.81, I2 = 0.00%) had significantly improved when the intervention group adopted Argatroban plus Antiplatelet.ConclusionArgatroban can improve neurological deterioration, with a low incidence of adverse events such as bleeding and death, and general analysis showed no improvement in mRS. However, subgroup analysis suggests that compared to mono-antiplatelet therapy, combination therapy of Argatroban combined with antiplatelet therapy significantly reduced the incidence of END and improved mRS scores. After using Argatroban, there was no increase in the risk and mortality of intracranial hemorrhage and other bleeding sites. |
| first_indexed | 2024-03-07T23:51:04Z |
| format | Article |
| id | doaj.art-6314092d15464b5e959bb2d791489753 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-07T23:51:04Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj.art-6314092d15464b5e959bb2d7914897532024-02-19T04:48:40ZengFrontiers Media S.A.Frontiers in Neurology1664-22952024-02-011510.3389/fneur.2024.13648951364895Efficacy and safety of Argatroban in patients with acute ischemic stroke: a systematic review and meta-analysisYiRan Cheng0ChangNing Liu1ShanShan Li2Miao Miao Meng3He Li4Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, ChinaNeurology Department of First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, ChinaNanjing University of Chinese Medicine, Nanjing, ChinaAffiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, ChinaNeurology Department of First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, ChinaObjectiveArgatroban is a highly promising drug for the treatment of acute ischemic stroke (AIS), but there is currently insufficient strong evidence regarding the efficacy and safety of using Argatroban in the treatment of AIS. Therefore, we conducted a systematic review and meta-analysis to evaluate the effectiveness and safety of Argatroban in the treatment of AIS.MethodsArticles on PubMed, Embase and the Cochrane Library databases were searched from these websites’ inceptions to 2th February 2023. Randomized controlled trials and observational studies on Argatroban therapy for acute ischemic stroke were included. Meta-analyses were conducted using a random-effects model.ResultsFourteen studies involving 10,315 patients were included in the meta-analysis. The results showed a significant reduction in the rate of early neurological deterioration (END) in the Argatroban group compared with the control group (OR = 0.47, 95% CI: 0.31–0.73, I2 = 15.17%). The rates of adverse events were no significant difference between the two groups (ICH: OR = 1.02, 95% CI: 0.68–1.51, I2 = 0.00%; major extracranial bleeding: OR = 1.22, 95% CI: 1.01–1.48, I2 = 0.00%; mortality: OR = 1.16, 95% CI: 0.84–1.59, I2 = 0.00%). However, the rates of mRS score of 0–1 (OR = 1.38, 95% CI: 0.71–2.67, I2 = 77.56%) and mRS score of 0–2 (OR = 1.18, 95% CI: 0.98–1.42, I2 = 0.00%) during the 90 days did not significantly improved in the Argatroban group. Subgroup analyses showed that the rate of END (OR = 0.41, 95% CI: 0.26–0.65, I2 = 2.77%) and mRS score of 0–2 (OR = 1.38, 95% CI: 1.06–1.81, I2 = 0.00%) had significantly improved when the intervention group adopted Argatroban plus Antiplatelet.ConclusionArgatroban can improve neurological deterioration, with a low incidence of adverse events such as bleeding and death, and general analysis showed no improvement in mRS. However, subgroup analysis suggests that compared to mono-antiplatelet therapy, combination therapy of Argatroban combined with antiplatelet therapy significantly reduced the incidence of END and improved mRS scores. After using Argatroban, there was no increase in the risk and mortality of intracranial hemorrhage and other bleeding sites.https://www.frontiersin.org/articles/10.3389/fneur.2024.1364895/fullacute ischemic strokeArgatrobanearly neurological deteriorationmeta-analysissystematic reviewstroke |
| spellingShingle | YiRan Cheng ChangNing Liu ShanShan Li Miao Miao Meng He Li Efficacy and safety of Argatroban in patients with acute ischemic stroke: a systematic review and meta-analysis Frontiers in Neurology acute ischemic stroke Argatroban early neurological deterioration meta-analysis systematic review stroke |
| title | Efficacy and safety of Argatroban in patients with acute ischemic stroke: a systematic review and meta-analysis |
| title_full | Efficacy and safety of Argatroban in patients with acute ischemic stroke: a systematic review and meta-analysis |
| title_fullStr | Efficacy and safety of Argatroban in patients with acute ischemic stroke: a systematic review and meta-analysis |
| title_full_unstemmed | Efficacy and safety of Argatroban in patients with acute ischemic stroke: a systematic review and meta-analysis |
| title_short | Efficacy and safety of Argatroban in patients with acute ischemic stroke: a systematic review and meta-analysis |
| title_sort | efficacy and safety of argatroban in patients with acute ischemic stroke a systematic review and meta analysis |
| topic | acute ischemic stroke Argatroban early neurological deterioration meta-analysis systematic review stroke |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2024.1364895/full |
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