Diabetic Retinopathy as a Predictor of Angiographic Coronary Atherosclerosis Severity in Patients with Type 2 Diabetes Mellitus
Mohamed Eid,1 Amr Mounir,2 Shehab El Etriby,3 Ali Al Taher,1 Mohamed AW Ezzat1 1Department of Internal Medicine, Sohag University Hospital, Sohag University, Sohag, Egypt; 2Department of Ophthalmology, Sohag Faculty of Medicine, Sohag University, Sohag, Egypt; 3Department of Cardiology, Ain Shams Fa...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-05-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
| Subjects: | |
| Online Access: | https://www.dovepress.com/diabetic-retinopathy-as-a-predictor-of-angiographic-coronary-atheroscl-peer-reviewed-fulltext-article-DMSO |
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| author | Eid M Mounir A El Etriby S Al Taher A Ezzat MAW |
| author_facet | Eid M Mounir A El Etriby S Al Taher A Ezzat MAW |
| author_sort | Eid M |
| collection | DOAJ |
| description | Mohamed Eid,1 Amr Mounir,2 Shehab El Etriby,3 Ali Al Taher,1 Mohamed AW Ezzat1 1Department of Internal Medicine, Sohag University Hospital, Sohag University, Sohag, Egypt; 2Department of Ophthalmology, Sohag Faculty of Medicine, Sohag University, Sohag, Egypt; 3Department of Cardiology, Ain Shams Faculty of Medicine, Ain Shams University, Cairo, EgyptCorrespondence: Amr Mounir, Email dramrmonir@yahoo.comBackground: Diabetic retinopathy (DR) is one of the most prevalent consequences of diabetes mellitus (DM). Much emphasis has been focused on the link between DR and cardiovascular disorders in patients with type 2 diabetes (T2DM). However, there is little information about the relation between the degree of DR and coronary atherosclerosis severity in Egyptian patients.Aim: To assess the correlation between the degree of DR and the coronary atherosclerosis severity in T2DM.Patients and Methods: This work included 140 diabetic patients with T2DM who underwent diagnostic coronary angiography because of suspected coronary artery disease (CAD). All participants were evaluated by history, fundus assessment, laboratory tests (lipid profile and glycated hemoglobin [HbA1c]), and selective coronary angiography. The severity of coronary artery lesion was detected by Gensini score and vessel score.Results: Patients with DR had a significantly higher Gensini score (67.86± 44.56 versus 5.93± 9.02, P < 0.001) and a vessel score (2.29± 0.86 versus 0.50± 0.66, P < 0.001). There was a significant relation between the degree of DR, Gensini score (P < 0.001), and vessel score (P < 0.001), as both scores increased according to the severity of DR. The presence and degree of retinopathy were the only independent factors linked to the severity score in multivariate linear regression analyses (P < 0.001).Conclusion: The presence and degree of DR are independent predictors of severe coronary atherosclerosis. Therefore, when evaluating whether a patient with T2DM is at high risk for CAD, the DR degree should be taken into consideration.Keywords: diabetic retinopathy, coronary atherosclerosis, type 2 diabetes mellitus, coronary angiography |
| first_indexed | 2024-04-10T18:01:37Z |
| format | Article |
| id | doaj.art-63157a34140d4e388502f000f65255ba |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T18:01:37Z |
| publishDate | 2022-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-63157a34140d4e388502f000f65255ba2023-02-02T15:26:50ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072022-05-01Volume 151485149475195Diabetic Retinopathy as a Predictor of Angiographic Coronary Atherosclerosis Severity in Patients with Type 2 Diabetes MellitusEid MMounir AEl Etriby SAl Taher AEzzat MAWMohamed Eid,1 Amr Mounir,2 Shehab El Etriby,3 Ali Al Taher,1 Mohamed AW Ezzat1 1Department of Internal Medicine, Sohag University Hospital, Sohag University, Sohag, Egypt; 2Department of Ophthalmology, Sohag Faculty of Medicine, Sohag University, Sohag, Egypt; 3Department of Cardiology, Ain Shams Faculty of Medicine, Ain Shams University, Cairo, EgyptCorrespondence: Amr Mounir, Email dramrmonir@yahoo.comBackground: Diabetic retinopathy (DR) is one of the most prevalent consequences of diabetes mellitus (DM). Much emphasis has been focused on the link between DR and cardiovascular disorders in patients with type 2 diabetes (T2DM). However, there is little information about the relation between the degree of DR and coronary atherosclerosis severity in Egyptian patients.Aim: To assess the correlation between the degree of DR and the coronary atherosclerosis severity in T2DM.Patients and Methods: This work included 140 diabetic patients with T2DM who underwent diagnostic coronary angiography because of suspected coronary artery disease (CAD). All participants were evaluated by history, fundus assessment, laboratory tests (lipid profile and glycated hemoglobin [HbA1c]), and selective coronary angiography. The severity of coronary artery lesion was detected by Gensini score and vessel score.Results: Patients with DR had a significantly higher Gensini score (67.86± 44.56 versus 5.93± 9.02, P < 0.001) and a vessel score (2.29± 0.86 versus 0.50± 0.66, P < 0.001). There was a significant relation between the degree of DR, Gensini score (P < 0.001), and vessel score (P < 0.001), as both scores increased according to the severity of DR. The presence and degree of retinopathy were the only independent factors linked to the severity score in multivariate linear regression analyses (P < 0.001).Conclusion: The presence and degree of DR are independent predictors of severe coronary atherosclerosis. Therefore, when evaluating whether a patient with T2DM is at high risk for CAD, the DR degree should be taken into consideration.Keywords: diabetic retinopathy, coronary atherosclerosis, type 2 diabetes mellitus, coronary angiographyhttps://www.dovepress.com/diabetic-retinopathy-as-a-predictor-of-angiographic-coronary-atheroscl-peer-reviewed-fulltext-article-DMSOdiabetic retinopathycoronary atherosclerosistype 2 diabetes mellituscoronary angiography |
| spellingShingle | Eid M Mounir A El Etriby S Al Taher A Ezzat MAW Diabetic Retinopathy as a Predictor of Angiographic Coronary Atherosclerosis Severity in Patients with Type 2 Diabetes Mellitus Diabetes, Metabolic Syndrome and Obesity diabetic retinopathy coronary atherosclerosis type 2 diabetes mellitus coronary angiography |
| title | Diabetic Retinopathy as a Predictor of Angiographic Coronary Atherosclerosis Severity in Patients with Type 2 Diabetes Mellitus |
| title_full | Diabetic Retinopathy as a Predictor of Angiographic Coronary Atherosclerosis Severity in Patients with Type 2 Diabetes Mellitus |
| title_fullStr | Diabetic Retinopathy as a Predictor of Angiographic Coronary Atherosclerosis Severity in Patients with Type 2 Diabetes Mellitus |
| title_full_unstemmed | Diabetic Retinopathy as a Predictor of Angiographic Coronary Atherosclerosis Severity in Patients with Type 2 Diabetes Mellitus |
| title_short | Diabetic Retinopathy as a Predictor of Angiographic Coronary Atherosclerosis Severity in Patients with Type 2 Diabetes Mellitus |
| title_sort | diabetic retinopathy as a predictor of angiographic coronary atherosclerosis severity in patients with type 2 diabetes mellitus |
| topic | diabetic retinopathy coronary atherosclerosis type 2 diabetes mellitus coronary angiography |
| url | https://www.dovepress.com/diabetic-retinopathy-as-a-predictor-of-angiographic-coronary-atheroscl-peer-reviewed-fulltext-article-DMSO |
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