| Summary: | Scalarane-type sesterterpenoids are known for their therapeutic potential in cancer treatments. However, the anti-inflammatory properties of this class of metabolites remain elusive. Our current work aimed to investigate the anti-inflammatory scalaranes from marine sponge <i>Lendenfeldia</i> sp., resulting in the isolation of six new 24-homoscalaranes, lendenfeldaranes E–J (<b>1</b>–<b>6</b>). The structures of the new metabolites were determined by extensive spectroscopic analyses, and the absolute configuration of <b>1</b> was established by electronic circular dichroism (ECD) calculations. Compounds <b>2</b> and <b>3</b> were discovered to individually reduce the generation of superoxide anions, and compound <b>1</b> displayed an inhibitor effect on the release of elastase. These three compounds were proven to be the first anti-neutrophilic scalaranes.
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