Multilineage Differentiating Stress Enduring (Muse) Cells: A New Era of Stem Cell-Based Therapy
Stem cell transplantation has recently demonstrated a significant therapeutic efficacy in various diseases. Multilineage-differentiating stress-enduring (Muse) cells are stress-tolerant endogenous pluripotent stem cells that were first reported in 2010. Muse cells can be found in the peripheral bloo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/13/1676 |
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| author | Raghad F. Alanazi Basma S. Alhwity Raghad M. Almahlawi Bashayer D. Alatawi Shatha A. Albalawi Raneem A. Albalawi Amaal A. Albalawi Mohamed S. Abdel-Maksoud Nehal Elsherbiny |
| author_facet | Raghad F. Alanazi Basma S. Alhwity Raghad M. Almahlawi Bashayer D. Alatawi Shatha A. Albalawi Raneem A. Albalawi Amaal A. Albalawi Mohamed S. Abdel-Maksoud Nehal Elsherbiny |
| author_sort | Raghad F. Alanazi |
| collection | DOAJ |
| description | Stem cell transplantation has recently demonstrated a significant therapeutic efficacy in various diseases. Multilineage-differentiating stress-enduring (Muse) cells are stress-tolerant endogenous pluripotent stem cells that were first reported in 2010. Muse cells can be found in the peripheral blood, bone marrow and connective tissue of nearly all body organs. Under basal conditions, they constantly move from the bone marrow to peripheral blood to supply various body organs. However, this rate greatly changes even within the same individual based on physical status and the presence of injury or illness. Muse cells can differentiate into all three-germ-layers, producing tissue-compatible cells with few errors, minimal immune rejection and without forming teratomas. They can also endure hostile environments, supporting their survival in damaged/injured tissues. Additionally, Muse cells express receptors for sphingosine-1-phosphate (S1P), which is a protein produced by damaged/injured tissues. Through the S1P–S1PR2 axis, circulating Muse cells can preferentially migrate to damaged sites following transplantation. In addition, Muse cells possess a unique immune privilege system, facilitating their use without the need for long-term immunosuppressant treatment or human leucocyte antigen matching. Moreover, they exhibit anti-inflammatory, anti-apoptotic and tissue-protective effects. These characteristics circumvent all challenges experienced with mesenchymal stem cells and induced pluripotent stem cells and encourage the wide application of Muse cells in clinical practice. Indeed, Muse cells have the potential to break through the limitations of current cell-based therapies, and many clinical trials have been conducted, applying intravenously administered Muse cells in stroke, myocardial infarction, neurological disorders and acute respiratory distress syndrome (ARDS) related to novel coronavirus (SARS-CoV-2) infection. Herein, we aim to highlight the unique biological properties of Muse cells and to elucidate the advantageous difference between Muse cells and other types of stem cells. Finally, we shed light on their current therapeutic applications and the major obstacles to their clinical implementation from laboratory to clinic. |
| first_indexed | 2024-03-11T01:45:09Z |
| format | Article |
| id | doaj.art-63180567c420455cbbbb027f6017b101 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T01:45:09Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-63180567c420455cbbbb027f6017b1012023-11-18T16:18:26ZengMDPI AGCells2073-44092023-06-011213167610.3390/cells12131676Multilineage Differentiating Stress Enduring (Muse) Cells: A New Era of Stem Cell-Based TherapyRaghad F. Alanazi0Basma S. Alhwity1Raghad M. Almahlawi2Bashayer D. Alatawi3Shatha A. Albalawi4Raneem A. Albalawi5Amaal A. Albalawi6Mohamed S. Abdel-Maksoud7Nehal Elsherbiny8Pharm D Program, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi ArabiaPharm D Program, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi ArabiaPharm D Program, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi ArabiaPharm D Program, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi ArabiaPharm D Program, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi ArabiaPharm D Program, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi ArabiaPharm D Program, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi ArabiaDepartment of Pharmacology & Toxicology, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi ArabiaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi ArabiaStem cell transplantation has recently demonstrated a significant therapeutic efficacy in various diseases. Multilineage-differentiating stress-enduring (Muse) cells are stress-tolerant endogenous pluripotent stem cells that were first reported in 2010. Muse cells can be found in the peripheral blood, bone marrow and connective tissue of nearly all body organs. Under basal conditions, they constantly move from the bone marrow to peripheral blood to supply various body organs. However, this rate greatly changes even within the same individual based on physical status and the presence of injury or illness. Muse cells can differentiate into all three-germ-layers, producing tissue-compatible cells with few errors, minimal immune rejection and without forming teratomas. They can also endure hostile environments, supporting their survival in damaged/injured tissues. Additionally, Muse cells express receptors for sphingosine-1-phosphate (S1P), which is a protein produced by damaged/injured tissues. Through the S1P–S1PR2 axis, circulating Muse cells can preferentially migrate to damaged sites following transplantation. In addition, Muse cells possess a unique immune privilege system, facilitating their use without the need for long-term immunosuppressant treatment or human leucocyte antigen matching. Moreover, they exhibit anti-inflammatory, anti-apoptotic and tissue-protective effects. These characteristics circumvent all challenges experienced with mesenchymal stem cells and induced pluripotent stem cells and encourage the wide application of Muse cells in clinical practice. Indeed, Muse cells have the potential to break through the limitations of current cell-based therapies, and many clinical trials have been conducted, applying intravenously administered Muse cells in stroke, myocardial infarction, neurological disorders and acute respiratory distress syndrome (ARDS) related to novel coronavirus (SARS-CoV-2) infection. Herein, we aim to highlight the unique biological properties of Muse cells and to elucidate the advantageous difference between Muse cells and other types of stem cells. Finally, we shed light on their current therapeutic applications and the major obstacles to their clinical implementation from laboratory to clinic.https://www.mdpi.com/2073-4409/12/13/1676muse cellsunique characteristicsapplicationsclinical trials |
| spellingShingle | Raghad F. Alanazi Basma S. Alhwity Raghad M. Almahlawi Bashayer D. Alatawi Shatha A. Albalawi Raneem A. Albalawi Amaal A. Albalawi Mohamed S. Abdel-Maksoud Nehal Elsherbiny Multilineage Differentiating Stress Enduring (Muse) Cells: A New Era of Stem Cell-Based Therapy Cells muse cells unique characteristics applications clinical trials |
| title | Multilineage Differentiating Stress Enduring (Muse) Cells: A New Era of Stem Cell-Based Therapy |
| title_full | Multilineage Differentiating Stress Enduring (Muse) Cells: A New Era of Stem Cell-Based Therapy |
| title_fullStr | Multilineage Differentiating Stress Enduring (Muse) Cells: A New Era of Stem Cell-Based Therapy |
| title_full_unstemmed | Multilineage Differentiating Stress Enduring (Muse) Cells: A New Era of Stem Cell-Based Therapy |
| title_short | Multilineage Differentiating Stress Enduring (Muse) Cells: A New Era of Stem Cell-Based Therapy |
| title_sort | multilineage differentiating stress enduring muse cells a new era of stem cell based therapy |
| topic | muse cells unique characteristics applications clinical trials |
| url | https://www.mdpi.com/2073-4409/12/13/1676 |
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