Cellular Mechanisms Underlying the Cardioprotective Role of Allicin on Cardiovascular Diseases
Cardiovascular diseases (CVDs) are a group of diseases in which the common denominator is the affection of blood vessels, heart tissue, and heart rhythm. The genesis of CVD is complex and multifactorial; therefore, approaches are often based on multidisciplinary management and more than one drug is...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/16/9082 |
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| author | José L. Sánchez-Gloria Abraham S. Arellano-Buendía Juan G. Juárez-Rojas Fernando E. García-Arroyo Raúl Argüello-García Fausto Sánchez-Muñoz Laura G. Sánchez-Lozada Horacio Osorio-Alonso |
| author_facet | José L. Sánchez-Gloria Abraham S. Arellano-Buendía Juan G. Juárez-Rojas Fernando E. García-Arroyo Raúl Argüello-García Fausto Sánchez-Muñoz Laura G. Sánchez-Lozada Horacio Osorio-Alonso |
| author_sort | José L. Sánchez-Gloria |
| collection | DOAJ |
| description | Cardiovascular diseases (CVDs) are a group of diseases in which the common denominator is the affection of blood vessels, heart tissue, and heart rhythm. The genesis of CVD is complex and multifactorial; therefore, approaches are often based on multidisciplinary management and more than one drug is used to achieve the optimal control of risk factors (dyslipidemia, hypertension, hypertrophy, oxidative stress, endothelial dysfunction, inflammation). In this context, allicin, a sulfur compound naturally derived from garlic, has shown beneficial effects on several cardiovascular risk factors through the modulation of cellular mechanisms and signaling pathways. Effective pharmacological treatments for CVD or its risk factors have not been developed or are unknown in clinical practice. Thus, this work aimed to review the cellular mechanisms through which allicin exerts its therapeutic effects and to show why it could be a therapeutic option for the prevention or treatment of CVD and its risk factors. |
| first_indexed | 2024-03-09T09:56:20Z |
| format | Article |
| id | doaj.art-631869fec54e43afae5b8d1c7299be9b |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T09:56:20Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-631869fec54e43afae5b8d1c7299be9b2023-12-01T23:47:22ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-08-012316908210.3390/ijms23169082Cellular Mechanisms Underlying the Cardioprotective Role of Allicin on Cardiovascular DiseasesJosé L. Sánchez-Gloria0Abraham S. Arellano-Buendía1Juan G. Juárez-Rojas2Fernando E. García-Arroyo3Raúl Argüello-García4Fausto Sánchez-Muñoz5Laura G. Sánchez-Lozada6Horacio Osorio-Alonso7Sección de Estudios de Posgrado, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City 11340, MexicoDepartment of Cardio-Renal Physiopathology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoDepartment of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoDepartment of Cardio-Renal Physiopathology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoDepartamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del IPN, Mexico City 07360, MexicoDepartment of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoDepartment of Cardio-Renal Physiopathology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoDepartment of Cardio-Renal Physiopathology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoCardiovascular diseases (CVDs) are a group of diseases in which the common denominator is the affection of blood vessels, heart tissue, and heart rhythm. The genesis of CVD is complex and multifactorial; therefore, approaches are often based on multidisciplinary management and more than one drug is used to achieve the optimal control of risk factors (dyslipidemia, hypertension, hypertrophy, oxidative stress, endothelial dysfunction, inflammation). In this context, allicin, a sulfur compound naturally derived from garlic, has shown beneficial effects on several cardiovascular risk factors through the modulation of cellular mechanisms and signaling pathways. Effective pharmacological treatments for CVD or its risk factors have not been developed or are unknown in clinical practice. Thus, this work aimed to review the cellular mechanisms through which allicin exerts its therapeutic effects and to show why it could be a therapeutic option for the prevention or treatment of CVD and its risk factors.https://www.mdpi.com/1422-0067/23/16/9082allicincardiovascular diseaserisk factorsdyslipidemiahypertensionhypertrophy |
| spellingShingle | José L. Sánchez-Gloria Abraham S. Arellano-Buendía Juan G. Juárez-Rojas Fernando E. García-Arroyo Raúl Argüello-García Fausto Sánchez-Muñoz Laura G. Sánchez-Lozada Horacio Osorio-Alonso Cellular Mechanisms Underlying the Cardioprotective Role of Allicin on Cardiovascular Diseases International Journal of Molecular Sciences allicin cardiovascular disease risk factors dyslipidemia hypertension hypertrophy |
| title | Cellular Mechanisms Underlying the Cardioprotective Role of Allicin on Cardiovascular Diseases |
| title_full | Cellular Mechanisms Underlying the Cardioprotective Role of Allicin on Cardiovascular Diseases |
| title_fullStr | Cellular Mechanisms Underlying the Cardioprotective Role of Allicin on Cardiovascular Diseases |
| title_full_unstemmed | Cellular Mechanisms Underlying the Cardioprotective Role of Allicin on Cardiovascular Diseases |
| title_short | Cellular Mechanisms Underlying the Cardioprotective Role of Allicin on Cardiovascular Diseases |
| title_sort | cellular mechanisms underlying the cardioprotective role of allicin on cardiovascular diseases |
| topic | allicin cardiovascular disease risk factors dyslipidemia hypertension hypertrophy |
| url | https://www.mdpi.com/1422-0067/23/16/9082 |
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