gC1qR/C1qBP/HABP-1: Structural Analysis of the Trimeric Core Region, Interactions With a Novel Panel of Monoclonal Antibodies, and Their Influence on Binding to FXII

gC1qR/C1qBP/HABP-1: Structural Analysis of the Trimeric Core Region, Interactions With a Novel Panel of Monoclonal Antibodies, and Their Influence on Binding to FXII

The protein gC1qR/C1qBP/HABP-1 plays an essential role in mitochondrial biogenesis, but becomes localized at the cellular surface in numerous pathophysiological states. When this occurs on endothelial cells, surface-exposed gC1qR activates the classical pathway of complement. It also promotes assemb...

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Bibliographic Details
Main Authors: Ying Zhang, Alexander J. Vontz, Ethan M. Kallenberger, Xin Xu, Nicoleta T. Ploscariu, Kasra X. Ramyar, Brandon L. Garcia, Berhane Ghebrehiwet, Brian V. Geisbrecht
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
gC1qR/C1qBP/HABP-1
FXII
protein-protein interactions
monoclonal antibodies
inhibitors
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.887742/full

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